Mucoadhesive Drug Delivery Systems

Muppalaneni, Srinath; Mastropietro, David J; Omidian, Hossein

doi:10.1002/9781118747896.ch10

Cited by 4 publications

(13 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mucoadhesion could be explained by some theories that include the electronic theory, the wetting theory, the adsorption theory, the diffusion theory, the mechanical theory, the cohesive theory, and the fracture theory [ 48 , 49 ].…”

Section: Mucoadhesive Polymeric Drug Delivery Systemsmentioning

confidence: 99%

“…Thus, both attractive and repulsive forces act and the adhesion process initiates only when the repulsive forces are surpassed. This initial step can be correlated to wetting, electronic, adsorption, and mechanical theories [ 48 ].…”

Section: Mucoadhesive Polymeric Drug Delivery Systemsmentioning

confidence: 99%

“…Initially, the adhesive polymer and glycoproteins from the mucous interact by interdiffusion and form secondary bonds. After that, the adhesive polymer forms an instantaneous gel hydrated by the aqueous environment [ 48 ]. This step is regarded as the diffusion and the cohesive theories, which enforce the idea that the mucoadhesion mechanism is better explained by combining all the mentioned theories [ 49 ].…”

Section: Mucoadhesive Polymeric Drug Delivery Systemsmentioning

confidence: 99%

“…The adsorption theory approaches the presence of intermolecular forces, namely, hydrogen bonding and Van der Waals forces, that act between the biological substrate and the adhesive material [ 51 ]. Despite the isolated interaction being weak, the combined effect of several forces could lead to strong interactions [ 48 ].…”

Section: Mucoadhesive Polymeric Drug Delivery Systemsmentioning

confidence: 99%

See 3 more Smart Citations

Mucoadhesive Polymers and Their Applications in Drug Delivery Systems for the Treatment of Bladder Cancer

Varca

Alves

Nogueira

et al. 2022

Gels

View full text Add to dashboard Cite

Bladder cancer (BC) is the tenth most common type of cancer worldwide, affecting up to four times more men than women. Depending on the stage of the tumor, different therapy protocols are applied. Non-muscle-invasive cancer englobes around 70% of the cases and is usually treated using the transurethral resection of bladder tumor (TURBIT) followed by the instillation of chemotherapy or immunotherapy. However, due to bladder anatomy and physiology, current intravesical therapies present limitations concerning permeation and time of residence. Furthermore, they require several frequent catheter insertions with a reduced interval between doses, which is highly demotivating for the patient. This scenario has encouraged several pieces of research focusing on the development of drug delivery systems (DDS) to improve drug time residence, permeation capacity, and target release. In this review, the current situation of BC is described concerning the disease and available treatments, followed by a report on the main DDS developed in the past few years, focusing on those based on mucoadhesive polymers as a strategy. A brief review of methods to evaluate mucoadhesion properties is also presented; lastly, different polymers suitable for this application are discussed.

show abstract

Section: Mucoadhesive Polymeric Drug Delivery Systemsmentioning

confidence: 99%

Section: Mucoadhesive Polymeric Drug Delivery Systemsmentioning

confidence: 99%

Section: Mucoadhesive Polymeric Drug Delivery Systemsmentioning

confidence: 99%

Section: Mucoadhesive Polymeric Drug Delivery Systemsmentioning

confidence: 99%

See 2 more Smart Citations

Mucoadhesive Polymers and Their Applications in Drug Delivery Systems for the Treatment of Bladder Cancer

Varca

Alves

Nogueira

et al. 2022

Gels

View full text Add to dashboard Cite

show abstract

“…The term mucoadhesion, a type of bioadhesion, is used when interfacial forces hold the polymer with the mucosal layer, a biolayer, which lines a number of regions of body as earlier mentioned. Since these regions represent potential sites for attachment of the mucoadhesive drug delivery system, these could be designed for buccal, oral, vaginal, rectal, nasal, and ocular route of administration …”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal Mucosa: The Target Site of Mucoadhesive Microspheres, A Review

Zaman

Sajid

Rehman

2015

Adv. Polym. Technol.

View full text Add to dashboard Cite

ABSTRACT:Mucoadhesive microspheres are one of the most promising novel techniques for drug delivery. Mucoadhesive systems offer a sustained drug release method, thus enhancing drug absorption in a site-specific manner. Microspheres have very small sizes and provide efficient carrier capacities. Mucoadhesive systems therefore play a vital role in drug delivery systems. Mucoadhesion is a two-step procedure, and its mechanism can be explained by combining theories of wetting, mechanical interlocking, electronic transfer, adsorption, fracture, and diffusion interpenetration, as deemed suitable. Mucoadhesive microspheres offer added advantages of reliability, safety, specificity, prolonged action, delayed release, and enhanced activity along with a very few disadvantages. These systems can be prepared by emulsion cross-linking, single emulsion, ionotropic gelation, phase inversion, spray drying, solvent removal, and hot melt methods. The resulting microspheres are characterized using a number of parameters such as size, surface, efficiencies, and release studies. Mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal, and vaginal applications with systemic as well as local effects. They give a chance to deliver the drugs which were not possible to administer by oral route. This review article gives an overview of mucoadhesive microspheres, their pros and cons, preparation methods, characterization, application, and recent developments. C 2015 Wiley Periodicals, Inc. Adv Polym Technol 2015, 0, 21550; View this article online at wileyonlinelibrary.com.

show abstract

A Window for Enhanced Oral Delivery of Therapeutics via Lipid Nanoparticles

Amekyeh,

Sabra,

Billa

2024

DDDT

View full text Add to dashboard Cite

Oral administration of dosage forms is convenient and beneficial in several respects. Lipid nanoparticulate dosage forms have emerged as a useful carrier system in deploying low solubility drugs systemically, particularly class II, III, and IV drugs of the Biopharmaceutics Classification System. Like other nanoparticulate delivery systems, their low size-to-volume ratio facilitates uptake by phagocytosis. Lipid nanoparticles also provide scope for high drug loading and extended-release capability, ensuring diminished systemic side effects and improved pharmacokinetics. However, rapid gastrointestinal (GI) clearance of particulate delivery systems impedes efficient uptake across the mucosa. Mucoadhesion of dosage forms to the GI mucosa results in longer transit times due to interactions between the former and mucus. Delayed transit times facilitate transfer of the dosage form across the mucosa. In this regard, a balance between mucoadhesion and mucopenetration guarantees optimal systemic transfer. Furthermore, the interplay between GI anatomy and physiology is key to ensuring efficient systemic uptake. This review captures salient anatomical and physiological features of the GI tract and how these can be exploited for maximal systemic delivery of lipid nanoparticles. Materials used to impart mucoadhesion and examples of successful mucoadhesive lipid nanoformulations are highlighted in this review.

show abstract

Mucoadhesive Drug Delivery Systems

Cited by 4 publications

References 73 publications

Mucoadhesive Polymers and Their Applications in Drug Delivery Systems for the Treatment of Bladder Cancer

Mucoadhesive Polymers and Their Applications in Drug Delivery Systems for the Treatment of Bladder Cancer

Gastrointestinal Mucosa: The Target Site of Mucoadhesive Microspheres, A Review

A Window for Enhanced Oral Delivery of Therapeutics via Lipid Nanoparticles

Contact Info

Product

Resources

About