Mucoadhesive drug carrier based on interpolymer complex of poly(vinyl pyrrolidone) and poly(acrylic acid) prepared by template polymerization

Chun, Myung Kwan; Cho, Chong Su; Choi, Hoo Kyun

doi:10.1016/s0168-3659(02)00078-0

Cited by 131 publications

(70 citation statements)

References 16 publications

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“…These forces are related to the chemical structure of the polymers [4]. Typical polymers that have been used as mucoadhesive drug carriers include poly(acrylic acid) (PAA), poly-(methacrylic acid), carboxymethyl cellulose and hydroxypropyl methylcellulose [5][6][7][8]. The high water solubility of PAA critically limits its use as a TMD system to be applied in the buccal mucous membrane, because it may dissolve before the desired duration for the drug to permeate across the membrane [9].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives

2014

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Abstract:A mucoadhesive drug delivery system can improve the effectiveness of a drug by maintaining the drug concentration and allowing targeting and localization of the drug at a specific site. Acrylic-based hydrogels have been used extensively as a mucoadhesive system owing to their flexibility and excellent bioadhesion. In this experiment, poly(acrylic acid) was selected to prepare the bioadhesive hydrogel adhering to mucosal surfaces using a radiation process. Poly(acrylic acid) was dissolved in water to a prepare poly(acrylic acid) solution, and the solution was then irradiated by an electron beam at up to 75 kGy to make hydrogels. Their physical properties, such as gel percent, swelling percent and adhesive strength to mucosal surfaces, were investigated. Triamcinolone acetonide was used as a model drug. The dried poly(acrylic acid) film was dipped in a 0.1 wt% triamcinolone acetonide solution in ethanol, and then dried at 25 °C. The release of triamcinolone acetonide was determined at different time intervals, and UV (Ultraviolet)-Vis spectroscopy was used to determine the released concentration of triamcinolone acetonide at 238 nm. It was shown that poly(acrylic acid)-based drug carriers were successfully prepared for use in a bioadhesive drug delivery system.

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Section: Introductionmentioning

confidence: 99%

Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives

2014

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“…Similar findings were previously demonstrated in studying the interaction between PVP and PAA. 17,42) Figure 4 shows the DSC thermograms of PVP K90, CP, their physical mixture, and kneaded mixture with 0.1 N HCl. In case of the PVP K90 thermogram, a sharp endothermic peak at 77.8°C was noted indicating the presence of bound water or moisture.…”

Section: Resultsmentioning

confidence: 99%

“…10,16) This excessive hydration of PAA can be significantly reduced by interpolymer complexation with polyvinylpyrrolidone (PVP). 17,18) Strong hydrogen bonding between PAA and PVP can connect the component polymers in the interpolymer complex (IPC) imparting physicochemical characteristics which are different from individual polymers. The produced IPC showed limited solubility in water and maintained the mucoadhesiveness.…”

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confidence: 99%

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Investigation and Evaluation of an <i>in Situ</i> Interpolymer Complex of Carbopol with Polyvinylpyrrolidone as a Matrix for Gastroretentive Tablets of Ranitidine Hydrochloride

Yusif

Hashim

Mohamed

et al. 2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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Carbopol (CP) is a biocompatible bioadhesive polymer used as a matrix for gastroretentive (GR) tablets, however, its rapid hydration shortens its bioadhesion and floating when incorporated in effervescent formulae. The interpolymer complexation of CP with polyvinylpyrrolidone (PVP) significantly reduced the excessive hydration of CP, prolonging floating and maintaining the mucoadhesiveness. In early attempts, a lengthy process was followed to prepare such an interpolymer complex. In this study, an in situ interpolymer complexation between CP and two grades of PVP (K25 and K90) in 0.1 N HCl was investigated and characterized by Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Hence, directly compressed GR tablets of different combinations of PVP and CP with sodium bicarbonate (SB) as an effervescent agent were examined for prolonged gastroretention and sustained release of ranitidine hydrochloride (RHCl) as a model drug. Tablets were evaluated for in vitro buoyancy, bioadhesiveness, swelling, and drug release in 0.1 N HCl. All GR tablets containing PVP-CP combinations achieved more prolonged floating (>24 h) than CP tablets (5.2 h). Their bioadhesiveness, swelling, and drug release were dependent on the PVP molecular weight and its ratio to CP. Drug release profiles of all formulae followed non-Fickian diffusion. Formula containing the PVP K90-CP combination at a respective ratio of 1 : 3 (P 90 C13) was a promising system, exhibiting good floating and bioadhesive properties as well as sustained drug release. Abdominal X-ray imaging of P 90 C13 formula, loaded with barium sulfate, in six healthy volunteers showed a mean gastric retention period of 6.8 0.3 h.

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“…Therefore, PVP (10,11,12) exhibiting a carboxylic moiety, and Pluronic F68 with polyether structure were chosen. In order to decide between the two polymers and to determine optimal ratios, titration experiments at varying ratios were performed and monitored by absorbance measurement at 400 nm.…”

Section: Formation Of Nanoparticlesmentioning

confidence: 99%

Development and in vivo evaluation of a new oral nanoparticulate dosage form for leuprolide based on polyacrylic acid

Iqbal¹,

Vigl²,

Moser³

et al. 2011

Drug Delivery

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Mucoadhesive drug carrier based on interpolymer complex of poly(vinyl pyrrolidone) and poly(acrylic acid) prepared by template polymerization

Cited by 131 publications

References 16 publications

Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives

Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives

Investigation and Evaluation of an <i>in Situ</i> Interpolymer Complex of Carbopol with Polyvinylpyrrolidone as a Matrix for Gastroretentive Tablets of Ranitidine Hydrochloride

Development and in vivo evaluation of a new oral nanoparticulate dosage form for leuprolide based on polyacrylic acid

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