Mucoadhesive buccal disks for novel nalbuphine prodrug controlled delivery: effect of formulation variables on drug release and mucoadhesive performance

Evaluation of Mechanical and Mucoadhesive Properties of Clomiphene Citrate Gel Formulations Containing Carbomers and Their Thiolated Derivatives

“…The mucoadhesive formulations, administered by rectal (Choi, Oh, and Kim 1998;Ryu et al 1999;Yahagi, Onishi, and Machida 1999), vaginal (Lee and Chien 1996;Valenta et al 2001;Ceschel et al 2001a;Cevher, Sahin, and Araman 2002;Chang et al 2002;Chien and Lee 2002;El-Kamel et al 2002;Maggi et al 2000), oral (Takeuchi et al 2003), buccal (Shojaei, Zhou, and Li 1998;Alur et al 1999;Han et al 1999;Choi and Kim 2000;Shin, Bum, and Choi 2000;Ceschel, Maffei, and Lombardi 2001b;Perioli et al 2004), nasal (Ugwoke et al 1999;Yahagi et al 2000;Pavelic, SkalkoBasnet, and Schubert, 2001;Hasçiçek, Gönül, and Erk 2003;58 E. CEVHER ET AL. Sales et al 2003), and ocular (Yun et al 1999;Ceulemans et al 2001) routes, have been prepared by using polymers showing appropriate adhesiveness.…”

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

“…Buccal discs are designed to minimize the discomfort caused due to bulky tablet buccal dosage forms. Several buccal discs have been extensively reported for successful delivery of therapeutic drug molecules (Han et al, 1999;El-Samaligy et al, 2004;Yehia et al, 2008;Jaipal et al, 2013;Sander et al, 2013).…”

Design and In Vitro/In Vivo Evaluation of Novel Mucoadhesive Buccal Discs of an Antifungal Drug: Relationship Between Swelling, Erosion, and Drug Release

“…The in vitro adhesion time of fluconazole discs was evaluated by assessing the time for these discs to detach from a chicken pouch membrane in a well-stirred beaker (8,15). The chicken pouch membranes were fixed on the side of the beaker with cyanoacrylate glue.…”