Mucoadhesive beads of gellan gum/pectin intended to controlled delivery of drugs

Prezotti, Fabíola Garavello; Cury, Beatriz Stringhetti Ferreira; Evangelista, Raul Cesar

doi:10.1016/j.carbpol.2014.07.021

Cited by 148 publications

(95 citation statements)

References 84 publications

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“…Na área farmacêutica, a crescente utilização da gelana pode ser exemplificada por diversos sistemas de liberação de fármacos descritos na literatura destinados ao tratamento dos mais diversos tipos de patologias, dentre eles estão os hidrogéis 113 , microesferas 112,117 , microcápsulas 118,119 , esferas flutuantes 123 , entre outros. Recentemente, a gelana tem sido estudada para aplicações biomédicas, mais precisamente na medicina regenerativa.…”

Section: Goma Gelanaunclassified

“…A DL 50 em ratos é de 16 g/kg 101 . 15 15 Sua característica hidrofílica e elevada capacidade de geleificação na presença de cátions di-ou trivalentes tem sido muito explorada para obtenção de novos sistemas para liberação controlada de fármacos 119,120 . Algumas de suas características, tais como atoxicidade, biodegradabilidade, baixo custo, propriedades mucoadesivas e degradação específica pela microbiota colônica 105 , a tornam um polissacarídeo atrativo e bastante promissor para o design de diferentes formas farmacêuticas.…”

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Biopolímeros: aplicações farmacêutica e biomédica

et al. 2016

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____________________________________________________________________________Resumo: O estudo e desenvolvimento de polímeros para aplicação nas áreas biomédica e farmacêutica têm aumentado devido às suas propriedades peculiares que contribuem para a melhoria da qualidade de vida, como por exemplo, os polímeros usados em medicina regenerativa e sistemas de liberação de fármacos. O desenvolvimento de novos materiais baseados em polímeros depende desde os métodos de síntese, extração ou composição desses materiais até os estudos da influência de suas estruturas e propriedades em aplicações específicas, entre outras. Esta revisão descreve o uso de alguns de polímeros novos e convencionais com potencial para aplicação nas áreas farmacêutica e biomédica, enfatizando as principais propriedades que os tornam aplicáveis. Palavras-chave: biopolímero, medicina regenerativa, liberação de fármacos ____________________________________________________________________________ Abstract:The study and development of polymers for pharmaceutical and biomedical use has been increasing due to their peculiar properties that contribute for the improvement of the life quality, such as the polymers used in regenerative medicine and in drug release systems. The development of new polymer based materials and its composites depends on several steps, such as the synthesis approach, the extraction, the composition, the influence of their properties on the specific applications, and others. This review describes the use of conventional and new polymers with potential application in pharmaceutical and biomedical fields, highlighting the properties that allow them to be useful for such purposes.

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Section: Goma Gelanaunclassified

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Biopolímeros: aplicações farmacêutica e biomédica

et al. 2016

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“…A strategy investigated for this purpose that has yielded technological advances for the development of delivery systems is the use of polymers in their design [10,11]. Many drugs formulations have polymers in their composition as excipients, usually polymers of natural origin considered safe in vivo [12]. A group of natural polymers that has probably led to most advances in the development of drug delivery systems technology is the class of polysaccharides, obtainable from various sources such as seaweed, plants, fungi, bacteria, animals and crustaceans [11,13].…”

Section: Introductionmentioning

confidence: 99%

Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility

Campos

Ferrari

Cassimiro

et al. 2015

J Therm Anal Calorim

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Praziquantel is an anthelmintic widely used in the treatment of schistosomiasis. Although a highly permeable drug, praziquantel is poorly soluble in water, limiting its bioavailability. Improving the solubility of poorly watersoluble drugs has become an important issue for analysis in pharmaceutical research. The use of dextran hydrogels is an advantageous strategy and the focus of extensive research. In this study, several hydrogels were developed from homologous polymer blends using 70 and 148 kDa dextrans in different proportions containing praziquantel, with the aim of evaluating the effects of polymeric release systems on the solubility of poorly water-soluble drugs such as praziquantel. Nine formulations were prepared, and the solubility of the drug incorporated was assessed. Three of the formations were selected to be characterized by DSC for the study in order to gain a better understanding of the thermal behavior of praziquantel incorporated into dextran hydrogels and the influence of polymers on the solubility of the drug, complemented by XRD and SEM techniques. According to the results, formation of crystallites of praziquantel occurred, probably due to the preparation procedures of the formulations, covering the surface of the polymer matrix and promoting a slight improvement in solubility.These data show that the use of hydrogels for the purposes of improving the solubility of poorly water-soluble drugs represents an effective strategy.

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“…Similarly, Prezotti and co-workers [212] obtained circular beads containing gellan gum and pectin by ionotropic gelation, but using Al 3+ as crosslinker, with high yield and entrapment efficiencies and sizes ranging between 728.95 and 924.56 μm but increased with higher polymer and crosslinker concentrations. Thermal analysis and Fourier transform infra-red spectroscopy showed the absence of drug-polymers interactions but high mucoadhesion both in vitro and ex vivo.…”

Section: Swelling and Drug Release Characterisation Studies On The Hymentioning

confidence: 99%

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Boateng

Okeke²,

Khan³

2015

CPD

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There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral (injections) and oral routes of administration. This is due to the several advantages they offer including avoiding first pass metabolism in the liver for oral administration and local activity which avoids the need for high systemic doses. To achieve the foregoing objectives, bioadhesive vehicles are required that ensure prolonged residence time to achieve systemic bioavailability via substantial drug absorption or significant drug concentration for local action.The drug delivery system is also required to be non-deleterious to the site of application and be well tolerated by vulnerable groups such as paediatric and geriatric patients. These essential characteristics are mainly satisfied by naturally occurring polymers, including polysaccharide based polymers which have the advantage of biocompatibility, biodegradability and therefore safety. This review discusses various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal (moist) surfaces including ocular, oral (buccal and sublingual), nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites. The anatomy and / or physiology of each site, coupled with the unique challenges each poses, the strategies employed for ensuring therapeutic efficacy, as well as the current state of the art will also be covered.

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Mucoadhesive beads of gellan gum/pectin intended to controlled delivery of drugs

Cited by 148 publications

References 84 publications

Biopolímeros: aplicações farmacêutica e biomédica

Biopolímeros: aplicações farmacêutica e biomédica

Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

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