Muco-adhesive Buccal Tablets of Clotrimazole for Oral Candidiasis

Khanna, Rajesh; Agarwal, Shivam; Ahuja, Alka

doi:10.3109/03639049709150554

Cited by 50 publications

(35 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The oral anatomy and the individuals' movement pattern of the tongue could also have caused variations. 32 The calculated equivalent amount of metronidazole (microbiologically active form) 33 released from the selected film over a period of 0.25 to 6.0 hours ranged from 5 to 15 µg/mL. This range was within and higher than the range of MIC reported for metronidazole against the anaerobic bacteria responsible for periodontal diseases (≈0.1-8 µg/mL).…”

Section: In Vivo Studiesmentioning

confidence: 83%

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

2007

View full text Add to dashboard Cite

The main objective of this study was to develop a local, oral mucoadhesive metronidazole benzoate (MET) delivery system that can be applied and removed by the patient for the treatment of periodontal diseases. Mucoadhesive micromatricial chitosan/poly(ε-caprolactone) (CH/PCL) films and chitosan films were prepared. Thermal behavior, morphology, and particle size measurements were used to evaluate the prepared films. The effect of different molar masses of CH and different ratios of medium Mwt molar mass chitosan (MCH):PCL on water absorption, in vitro bioadhesion, mechanical properties, and in vitro drug release was examined. In vivo performance of the selected formulation was also evaluated. Differential scanning calorimetry examination revealed that MET existed mainly in amorphous form. Under microscopic examination, PCL microparticles were homogeneously dispersed in the films. The use of different molar masses of CH and different ratios of (MCH):PCL affected the size of the entrapped particles. Addition of PCL significantly decreased percentage water uptake and bioadhesion force compared with pure CH film. With regard to mechanical properties, the 2-layered film containing 1:0.625 MCH:PCL had the best tensile properties. At fixed CH:PCL ratio (1:1.25), the slowest drug release was obtained from films containing high molar mass CH. On the other hand, the 2-layered film that consisted of 1:0.625 MCH:PCL had the slowest MET release. In vivo evaluation of the selected film revealed that metronidazole concentration in saliva over 6 hours ranged from 5 to 15 μg/mL, which was within and higher than the reported range of minimum inhibitory concentration for metronidazole. A significant in vitro/in vivo correlation under the adopted experimental conditions was obtained.

show abstract

Section: In Vivo Studiesmentioning

confidence: 83%

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

2007

View full text Add to dashboard Cite

show abstract

“…Buccal delivery also enables administerings drugs to patients who cannot be dosed orally via this route (Shojaei, 1998). Many mucoadhesive buccal films have been formulated to release drugs locally in order to treat for fungal infections in the oral cavity, such as oral candidiasis (Donnelly et al, 2007;Khanna et al, 1997;Rapka et al, 2003;Senel et al, 2000). Due to the versatility of the manufacturing processes, the release can be oriented either towards the buccal mucosa or towards the oral cavity (Morales, McConville, 2011).…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon

Saxena

Tewari

Saraf

2011

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl methyl cellulose (K4M), hydroxy propyl methyl cellulose (K15M), sodium carboxy methyl cellulose and poly vinyl pyrolidone (K30), plasticizer poly ethylene glycol (400) and a backing membrane of Eudragit (RL100). The films were evaluated in terms of swelling, residence time, mucoadhesion, release, and organoleptic properties. The optimized films showed lower release as compared to controlled drug delivery systems. Hence, an inclusion complex of acyclovir was prepared with hydrophilic polymer hydroxylpropyl beta-cyclodextrin in the molar ratio of 1:1. The inclusion complex was characterized by optical microscopy, FAB mass spectroscopy, and FTIR spectroscopy. Patches formulated with the acyclovir inclusion complex were evaluated along the same lines as those containing acyclovir alone. The in vitro release data revealed a substantial increase from 64.35% to 88.15% in the case of PS I and PS II batches, respectively, confirming the successful use of inclusion complexes for the formulation of buccal patch of acyclovir.

show abstract

“…The determination of longitudinal strain (percentage elongation at break) was carried out as described by Khanna et al (26). The percentage elongation at break for the film samples was calculated using the following formula (Eq.…”

Section: Evaluation Of Physicochemical Properties Of Filmsmentioning

confidence: 99%

Influence of the Component Excipients on the Quality and Functionality of a Transdermal Film Formulation

et al. 2015

View full text Add to dashboard Cite

Abstract. The influence of formulation variables, i.e., a hydrophilic polymer (Methocel ® E15) and a filmforming polymer (Eudragit ® RL 100 and Eudragit ® RS 100), on the physicochemical and functional properties of a transdermal film formulation was assessed. Several terpenes were initially evaluated for their drug permeation enhancement effects on the transdermal film formulations. D-Limonene was found to be the most efficient permeation enhancer among the tested terpenes. Transdermal film formulations containing granisetron (GRN) as a model drug, D-limonene as a permeation enhancer, and different ratios of a hydrophilic polymer (Methocel ® E15) and a film-forming polymer (Eudragit ® RL 100 or Eudragit ® RS 100) were prepared. The prepared films were evaluated for their physicochemical properties such as weight variation, thickness, tensile strength, folding endurance, elongation (%), flatness, moisture content, moisture uptake, and the drug content uniformity. The films were also evaluated for the in vitro drug release and ex vivo drug permeation. The increasing ratios of Methocel ® :Eudragit ® polymers in the formulation linearly and significantly increased the moisture content, moisture uptake, water vapor transmission rate (WVTR), and the transdermal flux of GRN from the film formulations. Increasing levels of Methocel ® in the formulations also increased the rate and extent of the GRN release and the GRN permeation from the prepared films.

show abstract

Muco-adhesive Buccal Tablets of Clotrimazole for Oral Candidiasis

Cited by 50 publications

References 11 publications

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon

Influence of the Component Excipients on the Quality and Functionality of a Transdermal Film Formulation

Contact Info

Product

Resources

About