Mucinous tubular and spindle cell carcinoma of the kidney: Five case reports and review of the literature

Abstract

Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a rare and polymorphic tumor, which has been previously considered to be a low-grade malignancy, predominantly occurring in women. To the best of our knowledge, MTSCC with bladder metastasis has never been reported. The current study presents five adult cases of MTSCC that included three male and two female patients. Among the male cases, two were of advanced stage, one with MTSCC and renal chromophobe cell carcinoma with bladder metastasis and the other with MTSCC with invasion of the renal vein. The other three cases with small masses were at an early stage. All five cases had a good prognosis and were without recurrence after several years of follow-up. A 70-year-old male with intermittent gross hematuria, intermittent renal colic, and groin radiation pain for a year (case 1), was incidentally detected to have a left renal density mass by total abdominal enhanced computed tomography scans. In the other four cases, renal masses were found by B-ultrasound. The patient in case 1 underwent a retroperitoneal laparoscopic radical nephroureterectomy with bladder cuff resection and transurethral resection of the bladder tumor, and received gemcitabine hydrochloride via intravesical instillation therapy plus cisplatin chemotherapy every 3 months. The patient in case 2 underwent an open left radical nephrectomy and renal pedicle lymph node dissection. The other three patients underwent a laparoscopic radical nephrectomy. All five patients had no recurrence or new metastasis in other organs after follow-up. In conclusion, the incidence of MTSCC in men and women is not as disparate as reported in previous publications. The characteristics of the images of the five adult cases in the present study showed a considerable consistency, with only minor differences. The malignancy and prognosis of MTSCC are still controversial, and thus inclusion and review of more cases is required to reach a definite final conclusion. Sunitinib and gemcitabine chemotherapy in combination with cisplatin may be effective for the therapy of MTSCC patients with metastasis, but a larger range of treatments needs to be identified.

Mucinous Tubular and Spindle Cell Renal Cell Carcinoma (MTSC-RCC) with an Unusual Presentation in a Child

“…The MTSC-RCC is a rare variant of renal cell carcinoma. This entity has been recently identified as a separate variant of RCC and had been classified in the 2004 World Health its rarity, there are few reports of response to Sunitinib, Gemitcitabine, or immunotherapy (ipilimumab and nivolumab) in a case of metastatic MTSC-RCC (10)(11)(12). In our case, the intraoperative findings precluded a safe surgical excision, and hence we had to resort to alternate strategies.…”

Mucinous tubular and spindle cell carcinoma of the kidney: a report of seven cases

“…The exact postoperative recurrence rate of MTSCC remains unclear. Based on a literature review, most cases had no recurrence after surgery [ 6 – 8 , 20 ], only a few cases mentioned postoperative recurrence [ 30 – 33 ], and some cases were not available, died of MTSCC or other diseases during the follow-up [ 6 , 7 , 9 , 29 ]. Therefore, the surgical recurrence rate cannot be accurately predicted due to the lack of accurate data in previous reports.…”

Mucinous Tubular and Spindle Cell Carcinoma of Kidney: A Case Report of a Rare Tumor

“…Mucinous tubular and spindle cell carcinoma of the kidney (MTSCC-K) is a rare tumour newly added to the World Health Organization (WHO) classification in 2004 (Bajpai et al, 2022). It is believed to be a low-grade malignant tumour with a good prognosis (Gong et al, 2020). The origin of MTSCC-K is still unclear and hypothesized to be either the loop of Henle or the collecting duct (Gong et al, 2020).…”

“…It is believed to be a low-grade malignant tumour with a good prognosis (Gong et al, 2020). The origin of MTSCC-K is still unclear and hypothesized to be either the loop of Henle or the collecting duct (Gong et al, 2020). MTSCC-K has a wide range of age distribution (from 13 to 82 years old) and a female predilection, sometimes found accidentally and asymptomatic (Sun et al, 2014).…”