Mucinous Cystic Neoplasms in Male Patients: Two Cases

Tamura, Shunsuke; Yamamoto, Hirotaka; Ushida, Shinichiro; Suzuki, Kazufumi

doi:10.4081/rt.2017.7096

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…Communication with the MPD is a critical distinguishing feature of pancreatic cysts (10). Similarly, the presence of a ductal communication may suggest a pseudocyst or walled-off necrosis in the setting of pancreatitis rather than other lesions such as MCN.…”

Section: Mucinous Cystic Neoplasmsmentioning

confidence: 99%

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Pancreatic Cystic Lesions and Malignancy: Assessment, Guidelines, and the Field Defect

et al. 2022

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The widespread use of high-spatial-resolution cross-sectional imaging has led to an increase in detection of incidental pancreatic cystic lesions. These lesions are a diverse group, ranging from indolent and premalignant lesions to invasive cancers. The diagnosis of several of these lesions can be suggested on the basis of their imaging appearance, while many other lesions require follow-up imaging and/or aspiration. The smaller cystic lesions, often branch-duct intraductal papillary mucinous neoplasms, have overlapping imaging characteristics that make diagnostic assessment of the natural history and malignancy risk confusing. Expert panels have developed societal guidelines, based on a consensus, for surveillance of these lesions. However, these guidelines are often inconsistent and are constantly evolving as additional scientific data are accumulated. Identification of features associated with increased risk of malignancy is important for proper management. The concept of field defect, whereby pancreatic adenocarcinoma develops at a site different from the site of the pancreatic cyst, adds to the complexity of screening guidelines. As a result of the differences in guidelines, key stakeholders (eg, radiologists, gastroenterologists, and surgeons) must review and come to a consensus regarding which guideline, or combination of guidelines, to follow at their individual institutions. Standardized reporting and macros are helpful for ensuring the uniformity of interpretations. Radiologists play a critical role in the detection and characterization of pancreatic cystic lesions, in the follow-up recommendations for these lesions, and in the detection of associated cancer.

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Section: Mucinous Cystic Neoplasmsmentioning

confidence: 99%

“…The histologic diagnosis is based on the presence of ovarian stromata (22). These lesions are extremely rare in male patients, with approximately 12 cases of MCNs with ovarian-like stromata reported (10).…”

Section: Serous Cystadenomamentioning

confidence: 99%

Pancreatic Cystic Lesions and Malignancy: Assessment, Guidelines, and the Field Defect

et al. 2022

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“…1 To date, studies have rarely shown that subclassification by morphological or molecular features correlates with prognosis. 2 However, in recent years treatment has evolved to include immunotherapy and targeted therapies; efficacy in PAIS remains uncertain, but such subclassification may prove to be beneficial for prognostic and predictive purposes. 3 Here we compare and contrast the morphological and molecular findings in three recent cases of PAIS at our institution, which demonstrate the variability seen in the context of a common clinical picture.…”

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confidence: 99%

“…Hyperplasia of mesonephric remnants is usually an incidental finding but may rarely form a clinically evident mass. An exuberant, florid type of mesonephric proliferation may be confused with either mesonephric adenocarcinoma or well differentiated endocervical adenocarcinoma 2,3 and can be exceedingly difficult to distinguish from endocervical mesonephric adenocarcinoma. We present a case of a 52-year-old female with a diagnostically challenging mesonephric proliferation.…”

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confidence: 99%

Renal papillary necrosis in a transplanted kidney

Simmons

Zwi

2022

Pathology

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a diagnosis of IgG4-RD has implications for systemic disease and therapy including possible requirement for long-term immunosuppression and risk of lymphoma. References 1. McKelvie P, McNab AA, Hardy T, et al. Comparative study of clinical, pathological, radiological and genetic features of patients with adult ocular adnexal xanthogranulomatous disease, Erdheim-Chester disease and IgG4-related disease of the orbit/ocular adnexa.

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Distinct Indications for Adjuvant Therapy in Resected Invasive Mucinous Cystic Neoplasms of the Pancreas Compared with Pancreatic Ductal Adenocarcinoma

Wong,

Pollini,

Adam

et al. 2024

Ann Surg Oncol

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Background Surgical and adjuvant management of mucinous cystic neoplasms (MCNs) lacks formal guidelines and data is limited to institutional studies. Factors associated with receipt of adjuvant therapy and any associated impact on survival remain to be clarified. In the absence of other data, guidelines that recommend adjuvant chemotherapy for invasive pancreatic adenocarcinoma have been extrapolated to MCN. Patients and Methods The National Cancer Database (2004–2019) was utilized to identify all patients that underwent pancreatic resection for invasive MCNs. Patients that received neoadjuvant therapy or did not undergo lymphadenectomy were excluded. Patient, tumor, and treatment factors associated with survival were assessed. Results For 161 patients with invasive MCN, median overall survival (OS) was 133 months and 45% of patients received adjuvant therapy. Multivariable analysis demonstrated that poorly differentiated tumors [odds ratio (OR) 4.19, 95% confidence interval (CI) 1.47–11.98; p = 0.008] and positive lymph node status (OR 2.67, 95% CI 1.02–6.98; p = 0.042) were independent predictors of receiving adjuvant therapy. Lymph node positivity [hazard ratio (HR) 2.90, 95% CI 1.47–5.73; p = 0.002], positive margins (HR 5.28, 95% CI 2.28–12.27; p < 0.001), and stage III disease (HR 12.46, 95% CI 1.40–111.05; p = 0.024) were associated with worse OS. Receipt of adjuvant systemic therapy was independently associated with decreased risk of mortality in node positive patients (HR 0.23, 95% CI 0.10–0.69; p = 0.002). Survival was not associated with adjuvant therapy in patients with negative lymph nodes or margin negative status. Conclusion In contrast to pancreatic ductal adenocarcinoma (PDAC), where adjuvant therapy improves OS for every tumor stage, surgery alone for invasive MCN is not associated with improved OS compared with surgery plus adjuvant therapy in node-negative patients. Surgery alone is likely sufficient for a subset of invasive MCN.

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Mucinous Cystic Neoplasms in Male Patients: Two Cases

Cited by 5 publications

References 15 publications

Pancreatic Cystic Lesions and Malignancy: Assessment, Guidelines, and the Field Defect

Pancreatic Cystic Lesions and Malignancy: Assessment, Guidelines, and the Field Defect

Renal papillary necrosis in a transplanted kidney

Distinct Indications for Adjuvant Therapy in Resected Invasive Mucinous Cystic Neoplasms of the Pancreas Compared with Pancreatic Ductal Adenocarcinoma

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