Mucinous Cystadenocarcinoma of the Parotid Gland

Schneller, Janet; Solomón, Michael R.; Webber, C; Nasim, Mansoor

doi:10.1159/000327872

Cited by 12 publications

(2 citation statements)

References 2 publications

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“…Accordingly, FNA can reveal sparse clusters of tumour cells that are vacuolated, with relatively bland nuclei and background mucinous cystic fluid. [68][69][70] Higher-grade malignancies may be more cellular and include papillary clusters of glandular cells. These malignancies lack an admixture of mucous and squamous cells, in contrast to cystic MEC.…”

Section: Mucinous C Ys Ti C Le S I On Smentioning

confidence: 99%

“…The grade and histological characteristics of these cancers determine their cytological characteristics. Accordingly, FNA can reveal sparse clusters of tumour cells that are vacuolated, with relatively bland nuclei and background mucinous cystic fluid 68–70 . Higher‐grade malignancies may be more cellular and include papillary clusters of glandular cells.…”

Section: Mucinous Cystic Lesionsmentioning

confidence: 99%

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Cystic lesions in the salivary gland. Pitfalls to be avoided on cytology

et al. 2023

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Cystic lesions of the salivary glands are very uncommon entities. However, on occasion, some neoplasms of the salivary glands show a cystic component, which may be predominant or only partially cystic. Basal cell adenoma, canalicular adenoma, oncocytoma, sebaceous adenoma, intraductal papilloma, epithelial‐myoepithelial carcinoma, intraductal carcinoma, and secretory carcinoma are such cystic entities. Cystic degeneration and necrosis, which can develop within solid tumours, represent another possibility. The ability to recognise this type of lesion is a challenge in diagnostic cytology because hypocellular fluid is frequently recovered. Furthermore, evaluating all of the differential diagnoses for cystic lesions of the salivary glands is helpful in obtaining the correct diagnosis. Herein, we evaluate the various types of cystic lesions within the salivary glands.

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Section: Mucinous C Ys Ti C Le S I On Smentioning

confidence: 99%

Section: Mucinous Cystic Lesionsmentioning

confidence: 99%

Cystic lesions in the salivary gland. Pitfalls to be avoided on cytology

et al. 2023

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Mucoepidermoid carcinoma: Analysis of 76 cytologic cases and correlation with histologic grade

Wakely

2022

Cancer Cytopathology

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BACKGROUND: Mucoepidermoid carcinoma (MEC) is the most common salivary gland (SG) malignancy. In this study, the author undertook analysis of a large collection of MEC cytologic cases. MATERIALS AND METHODS: Cytopathology files were searched for MEC cases with histopathologic confirmation. Fine-needle aspiration (FNA) smears used standard technique. RESULTS: Seventy-six cases (63 patients [M:F = 1:1; age range, 23-87 years; mean age, 58 years]) met inclusion criteria. Aspirates were primary (54 [71%]), metastatic (18 [24%]), and locally recurrent (4 [5%]). FNA sites included parotid gland (49 [64%]), regional lymph nodes (11 [14%]), submandibular gland (5 [7%]), inner canthus of eye (2 [3%]), and lung (2 [3%]); and single specimens from palate, jaw, shoulder, paranasal sinus, floor of mouth, ear canal, and effusion. Cytologic diagnoses included MEC (30 cases [39%]), suspicious for MEC (16 [21%]), non-MEC carcinoma (9 [12%]), suspicious for malignancy (SM) (2 [3%], malignant (M) (1 [1%]), SG and/or suspicious SG neoplasm (7 [8%]), atypical (3 [5%]), nonneoplastic (5 [6%]), nondiagnostic (2 [3%]), and benign SG neoplasm (1 [1%]). A total of 26% of low-grade (LG) cases were diagnosed as malignant in contrast to 87% malignant in high-grade (HG) cases. Cytomorphology depended on tumor grade.LG MEC contained intra-and/or extra-cellular mucin and more uniform cell and/or nuclear morphology, whereas cytologic atypia, anisonucleosis, and keratotic cells were more typical of HG tumors. CONCLUSION: A malignant (M) or suspicious for malignancy (SM) cytologic interpretation was made in 76% of mucoepidermoid carcinoma (MEC) cases. In contrast to high-grade MEC (97% identified as M/SM), only 59% of low-grade (LG) MEC cases were interpreted as such, illustrating the continued diagnostic challenge posed by LG MEC using fine-needle aspiration biopsy. Cancer Cytopathol 2022;.

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Cytomorphologic features of papillary cystadenocarcinoma of the parotid

Kapila

Verma

2002

Diagnostic Cytopathology

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The fine-needle aspiration cytology findings in four cases of recently classified cystadenocarcinoma of the parotid gland are reported. In three cases a recurrent tumor was aspirated. Smear preparations in all four cases were cellular, with numerous papillary projections, single cells, and sheets of cells in varying proportion in a proteinaceous to mucoid background. The background mucin was in varying proportions. The cells were cuboidal to tall columnar with basal nuclei and mild pleomorphism. The cytoplasm was dense in three cases with variable amounts of mucin. In one case (Case 4) the epithelial cells resembled mucin-secreting goblet cells, while in another case (Case 1) the cytoplasm showed multiple vacuolations. Mitosis was rare. Lymphoid tissue was seen in one case while macrophages and giant cells were seen in two cases. Epidermoid differentiation was absent in all four cases. Pathologic evaluation of the resected tumor confirmed the cytologic diagnosis. Clinical and radiologic evaluation failed to reveal any other potential primary site. Papillary cystadenocarcinomas of the parotid are rare but can be accurately diagnosed on FNAC. However, they need to be differentiated from mucoepidermoid and papillary acinic cell tumors.

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Mucinous Cystadenocarcinoma of the Parotid Gland

Cited by 12 publications

References 2 publications

Cystic lesions in the salivary gland. Pitfalls to be avoided on cytology

Cystic lesions in the salivary gland. Pitfalls to be avoided on cytology

Mucoepidermoid carcinoma: Analysis of 76 cytologic cases and correlation with histologic grade

Cytomorphologic features of papillary cystadenocarcinoma of the parotid

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