Mucinous Cystadenocarcinoma of the Ovary

Woodruff, J. Donald; Perry, Henry B.; Genadry, Rene R.; Parmley, Tim H.

doi:10.1097/00006250-197804000-00020

Cited by 10 publications

(5 citation statements)

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“…Intestinal MBTs and endocervical MBTs share few clinicopathological features, and the features of endocervical MBTs resemble endometrioid tumours more closely than any other types of ovarian epithelial tumours. First, intestinal MBTs have the lowest frequency of bilaterality (0–10%) among ovarian epithelial tumours, 15–17 and association with endometriosis is exceptionally rare 1 . Endocervical MBTs, in turn, are commonly bilateral (12–47%), 1,6,7,11–13 and are often associated with endometriosis (30–53% of cases) 1,6,7,11–13 .…”

Section: Discussionmentioning

confidence: 99%

Endocervical‐like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Endocervical‐like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation

et al. 2010

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“…There are several theories accounting for the origin of ovarian mucinous carcinoma. It is well recognized that a subset of mucinous carcinomas can develop in association with ovarian teratomas; however, the majority of these tumors do not harbor any teratomatous component [ 49 , 50 ]. Other theories regarding the origin of these tumors include mucinous metaplasia of surface epithelial inclusions, endometriosis, and Brenner tumors [ 23 , 50 ].…”

Section: Type Imentioning

confidence: 99%

“…It is well recognized that a subset of mucinous carcinomas can develop in association with ovarian teratomas; however, the majority of these tumors do not harbor any teratomatous component [ 49 , 50 ]. Other theories regarding the origin of these tumors include mucinous metaplasia of surface epithelial inclusions, endometriosis, and Brenner tumors [ 23 , 50 ]. However, it is exceedingly rare to find mucinous metaplasia of the ovarian surface epithelium or within the lining of cortical inclusion cysts [ 51 , 52 ], and there have only been a few case reports of such findings [ 53 , 54 ].…”

Section: Type Imentioning

confidence: 99%

Recent Concepts of Ovarian Carcinogenesis: Type I and Type II

Koshiyama

Matsumura

Konishi

2014

BioMed Research International

190

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Type I ovarian tumors, where precursor lesions in the ovary have clearly been described, include endometrioid, clear cell, mucinous, low grade serous, and transitional cell carcinomas, while type II tumors, where such lesions have not been described clearly and tumors may develop de novo from the tubal and/or ovarian surface epithelium, comprise high grade serous carcinomas, undifferentiated carcinomas, and carcinosarcomas. The carcinogenesis of endometrioid and clear cell carcinoma (CCC) arising from endometriotic cysts is significantly influenced by the free iron concentration, which is associated with cancer development through the induction of persistent oxidative stress. A subset of mucinous carcinomas develop in association with ovarian teratomas; however, the majority of these tumors do not harbor any teratomatous component. Other theories of their origin include mucinous metaplasia of surface epithelial inclusions, endometriosis, and Brenner tumors. Low grade serous carcinomas are thought to evolve in a stepwise fashion from benign serous cystadenoma to a serous borderline tumor (SBT). With regard to high grade serous carcinoma, the serous tubal intraepithelial carcinomas (STICs) of the junction of the fallopian tube epithelium with the mesothelium of the tubal serosa, termed the “tubal peritoneal junction” (TPJ), undergo malignant transformation due to their location, and metastasize to the nearby ovary and surrounding pelvic peritoneum. Other theories of their origin include the ovarian hilum cells.

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“…On the light microscopic level, as the degree of malignancy increased, the shape and size of the columnar epithelial cells became more irregular and the number of secretory granules diminished. T h e maximum number of mitoses per high-power field also corre-lated with prognosis (36). The number of nucleoli increased with increasing malignancy, as in other tumors of the female genital tract (21,22).…”

Section: Discussionmentioning

confidence: 94%

Morphology of Ovarian Mucinous Cystadenoma: Surface Ultrastructure, Development and Biologic Behavior

Stenbäck

1980

International Journal of Gynecology & Obstetrics

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Thirty mucinous cystadenomas, borderline tumors and cystadenocarcinomas were analyzed by scanning and transmission electron microscopy. Results were compared to those obtained by light microscopy. Benign tumors consisted of endocervical-type columnar, mucus-containing cells with microvilli and cilia, goblet cells and intestinal-type microvillous cells. Borderline tumors showed a decrease in number and size of specialized surface structures in relation to degree of cellular atypia, the number of nucleoli and nuclear indentations indicating areas of incipient malignancy. Invasive carcinomas consisted mainly of intestinal-like surface cells varying in size and shape in relation to degree of tumor differentiation.

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Mucinous Cystadenocarcinoma of the Ovary

Cited by 10 publications

References 0 publications

Endocervical‐like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation

Endocervical‐like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation

Recent Concepts of Ovarian Carcinogenesis: Type I and Type II

Morphology of Ovarian Mucinous Cystadenoma: Surface Ultrastructure, Development and Biologic Behavior

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