Mucinous cholangiocarcinoma: an unusual complication of hepatolithiasis and recurrent pyogenic cholangitis

Chow, Louis T. C.; Ahuja, Anil T.; Kwong, Karen L.; Fung, K.S.C.; Lai, Ching‐Long; Lau, Joseph W.Y.

doi:10.1046/j.1365-2559.1997.00542.x

Cited by 41 publications

(20 citation statements)

References 3 publications

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“…There have been six reports of 39 patients with papillary PC 6–11. Three reports of 26 patients with complete clinical data and follow‐up were available for review (Table 4).…”

Section: Resultsmentioning

confidence: 99%

“…This tumor has a papillary growth pattern and may be associated with intraductal mucin accumulation. Twenty‐eight cases of intraductal papillary PC of the liver have been reported in the literature 6–11. Reports have suggested a less aggressive tumor biology, with potential long‐term survival, but the rarity of these tumors has limited information on outcome.…”

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confidence: 99%

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Hepatic intraductal oncocytic papillary carcinoma

Martin

Klimstra

Schwartz

et al. 2002

Cancer

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BACKGROUND There has been an increasing incidence and mortality from peripheral cholangiocarcinoma (PC) in the United States over the past 24 years. PC has been classified into two principal types, a mass‐forming type and a periductal‐infiltrating type, with a significant difference in the clinical behavior between the two. A third type, demonstrating a noninvasive intraductal growth of PC, was described as papillary PC. Rarely, papillary hepatic tumors composed of oncocytic cells have been described. Intraductal oncocytic papillary carcinomas (IOPCs) of the liver present as large, mucin‐filled, cystic lesions lined by noninvasive or focally microinvasive oncocytic tumors. METHODS From June 1999 to August 2001, three patients with hepatic IOPCs were identified in the files of the Hepatobiliary Service, Department of Surgery, and the Department of Pathology at Memorial Sloan‐Kettering Cancer Center. They form the basis of this study. We report the clinicopathologic presentation, as well as the outcome, with a review of the literature. RESULTS All three cases presented with well defined intrahepatic cystic masses ranging in size from 7.2 to 21.1 cm. The most prominent cells of the lining epithelium were columnar with oncocytic features showing abundant eosinophilic granular cytoplasm and centrally located nucleoli. All three patients underwent resection with one demonstrating local bile duct recurrence that was managed with stenting. Review of the literature has identified 39 patients with papillary PC and 2 patients with IOPC. The biology of these reported cases has been variable with overall survival better than that of nonpapillary PC patients, with recurrence in 15% of the reported cases. CONCLUSION Papillary PC is a rare type of cholangiocarcinoma that includes an interesting variant: IOPC. These tumors are predominantly found in men, who present with large (> 5 cm) mucinous cystic lesions of the bile duct. A noninvasive histology is seen, and long‐term survival may be achieved with complete resection. Invasive variants of IOPC have been reported in the literature and have a worse overall prognosis. Cancer 2002;95:2180–7. © 2002 American Cancer Society. DOI 10.1002/cncr.10934

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“…There have been six reports of 39 patients with papillary PC 6–11. Three reports of 26 patients with complete clinical data and follow‐up were available for review (Table 4).…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Hepatic intraductal oncocytic papillary carcinoma

Martin

Klimstra

Schwartz

et al. 2002

Cancer

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“…At histopathologic analysis, intraductal papillary adenocarcinoma, adenoma, and dysplasia typically are found, frequently in coexistence (2,3,6,8). The tumor is friable and tends to slough, causing intermittent biliary obstruction that may simulate biliary stone and recurrent pyogenic cholangitis (8,9,12). A definitive diagnosis is most often made at surgery.…”

Section: Pathologic Descriptionmentioning

confidence: 99%

Intraductal Papillary Mucinous Tumor of the Bile Ducts

Lim¹,

Yoon²,

Kim³

et al. 2004

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Papillary tumors of the bile ducts are intraductal tumors with numerous minute frondlike papillary projections. Some intraductal papillary tumors of the bile ducts produce a large amount of mucin that disturbs bile flow and causes severe biliary dilatation. In the presence of a tumor of this subgroup, the entire biliary tree is dilated; segmental or lobar bile ducts are dilated disproportionately, and aneurysmal dilatation may occur. Mucin is depicted at cholangiography as multiple elongated or cordlike filling defects, and the tumor is depicted on cross-sectional images as a castlike, polypoid, or fungating mass in the dilated biliary tree. Based on these characteristic imaging features-dilatation, mucin, and tumor-correct diagnosis of intraductal papillary mucinous tumor of the bile ducts may be made.

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“…1 Although mass-forming cholangiocarcinomas demonstrate an intense FDG uptake 11,12 as IPMN-B did in the present case, malignant IPMN-B may be easily differentiated from cholangiocarcinomas by CT and MRI, because the cholangiocarcinomas manifest as nodular masses. 1 Both IPMN-B and recurrent pyogenic cholangitis with bile duct stones involve intermittent and incomplete biliary obstruction and intraluminal masses or filling defect at images.…”

Section: Figurementioning

confidence: 50%

FDG PET/CT Findings in Malignant Intraductal Papillary Mucinous Neoplasm of the Bile Ducts

Takanami

Hiraide²,

Kaneta³

et al. 2010

Clinical Nuclear Medicine

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A 58-year-old man with no significant symptoms was referred to the hospital due to the presence of an intrahepatic cystic tumor and a dilated intrahepatic bile duct. F-18 FDG PET/CT demonstrated intense FDG uptake in the marginal region of the cystic tumor. Subsequently, the patient underwent a right hemihepatectomy with extrahepatic bile duct resection. The histopathology revealed a malignant intraductal papillary mucinous neoplasm of the bile ducts with dysplasia. This report thus documents the FDG PET findings in malignant intraductal papillary mucinous neoplasm of the bile ducts, which showed an intense FDG uptake in the tumor.

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Mucinous cholangiocarcinoma: an unusual complication of hepatolithiasis and recurrent pyogenic cholangitis

Cited by 41 publications

References 3 publications

Hepatic intraductal oncocytic papillary carcinoma

Hepatic intraductal oncocytic papillary carcinoma

Intraductal Papillary Mucinous Tumor of the Bile Ducts

FDG PET/CT Findings in Malignant Intraductal Papillary Mucinous Neoplasm of the Bile Ducts

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