Mucinous carcinoma of the breast: a comparative study on cytohistological findings associated with neuroendocrine differentiation

Abstract

Mucinous carcinoma with high ND may be diagnosed by the presence of discohesiveness, a flat, monolayered pattern, and round or eccentrically located nuclei. Features of ND in carcinomas in other organs, such as intracytoplasmic granules and coarse chromatin, may not be reliable cytological features of ND in MCA.

The effect of the extent of neuroendocrine differentiation on cytopathological findings in primary neuroendocrine neoplasms of the breast

“…Although these findings are compatible with some of the existing literature,[ 33 40 ] in the case series of Thiha et al .,[ 32 ] small cell size was observed in 6 of 7 cases and pleomorphism was not detected. In the study of Ohashi et al .,[ 34 ] no significant nuclear size difference was observed between the group with high neuroendocrine differentiation and the group with low neuroendocrine differentiation. However, large cells with an atypical, round-elongated nucleus and the presence of molding should be warning for poorly differentiated breast neuroendocrine carcinoma.…”

“…Ohashi et al . [ 34 ] observed moderate-to-severe cohesion loss in 94.4% of mucinous carcinomas with a high rate of neuroendocrine differentiation, whereas they did not detect significant discohesion in the group with low neuroendocrine differentiation. In different case series and case reports, it was observed that cohesion loss was significant in cases with neuroendocrine differentiation.…”

“…However, in Ohashi et al . 's[ 34 ] series of mucinous breast carcinoma with neuroendocrine differentiation consisting of 37 cases, there was no significant difference in cellularity between the group with a high rate of neuroendocrine differentiation (staining ≥15% with neuroendocrine markers) and the group with a low rate of neuroendocrine differentiation (staining <15% with neuroendocrine markers). In different case series and case reports, cellularity is reported to be high or moderate.…”

Breast‐conserving therapy shows better prognosis in mucinous breast carcinoma compared with mastectomy: A SEER population‐based study

“…Mucinous breast carcinoma (MBC), termed as colloid cancer, is a relatively rare pathological type of breast cancer. Its incidence accounts for approximately 1% to 7% of the primary breast cancers 1‐6 …”

Severe Bilateral Breast Mucinous Carcinoma with Bilateral Lungs and Cutaneous Metastasis: A Case Report and Literature Review

“…Breast mucinous carcinoma (BMC) is a rare histologic type breast cancer [ 1 , 2 ]. This cancer, except for the micropapillary pattern, usually occurs in elderly patients and presents a relatively good prognosis compared with more common types of breast cancer [ 3 ].…”