Mucinous carcinoid of the ovary: report of a case with metastasis in the contralateral ovary after ten years

Buis, Christien C.M; Doorn, Helena C. van; Dinjens, Winand N.M.; Ewing, Patricia C.

doi:10.4081/rt.2010.e39

Cited by 13 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major differential diagnoses were the metastatic mucinous carcinoid tumours. 37 Neuroendocrine tumours, accounting for 98.8% of all cases, mainly occur in the gastrointestinal tract (73.7%) and respiratory tract (25.1%). 4 Therefore, in order to be able to diagnose a primary ovarian carcinoid tumour it is essential to first exclude metastasis.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis of primary carcinoid tumour of the ovary arising in mature cystic teratomas

et al. 2021

View full text Add to dashboard Cite

Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of patients with primary ovarian carcinoid tumours arising in mature cystic teratomas. Methods This retrospective case series analysed the data from patients with primary ovarian carcinoid tumours arising in mature cystic teratomas. Results The study enrolled four patients. Histopathological analysis of the tumours identified the following subtypes: insular ( n = 1), trabecular ( n = 1) and strumal ( n = 2). All four primary ovarian carcinoid tumours originated from a mature teratoma. The morphology of the primary ovarian carcinoids was similar to other neuroendocrine tumours. Strumal carcinoids were composed of different proportions of thyroid tissue intimately admixed with carcinoid tumour. Tumour tissue was arranged in insular and/or trabecular patterns. The nucleus of tumour cells displayed exquisite chromatin without obvious mitotic figures. Tumour tissues were positively stained for neuroendocrine markers chromogranin A, synaptophysin and CD56 to varying degrees. Strumal carcinoid tumours were cytokeratin 19 positive and thyroid transcription factor 1 negative. No recurrence or metastasis occurred during follow-up (12–71 months). Conclusion Primary ovarian carcinoid tumours arising in mature cystic teratomas are rare. Diagnosis and differential diagnosis should be confirmed by clinical features, histopathological characteristics and specific immunophenotyping.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis of primary carcinoid tumour of the ovary arising in mature cystic teratomas

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The prognosis is expected to be favorable in patients with primary well differentiated mucinous carcinoid tumor of the ovary, although sporadic cases of metastasis has been reported. 5,9 Owing to the rarity of these tumors, very little is known about their clinical behavior and well differentiated ovarian mucinous carcinoid tumors are managed with surgical removal alone. Follow-up of patients and regular surveillance are also critical.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 Fewer than thirty cases of primary ovarian mucinous carcinoid tumors have been reported in the literature and the clinicopathologic behavior of this type of tumor has not been well characterized. [5][6][7] In this report, we describe the clinicopathologic and immunohistochemical features of a primary mucinous carcinoid tumor of the ovary associated with a mature cystic teratoma.…”

Section: Introductionmentioning

confidence: 98%

Primary Mucinous Carcinoid of the Ovary Arising in a Mature Cystic Teratoma: A Case Report with Review of the Literature

Huang¹,

Kumarapeli²,

Chen³

et al. 2012

N A J Med Sci

View full text Add to dashboard Cite

Primary mucinous carcinoid of the ovary is an extremely rare neoplasm with less than thirty cases reported in the English literature. The clinical behavior and pathologic features have not been well characterized. Here we report a case of a 42-year-old female who underwent laparoscopic salpingooophorectomy for a left ovarian mass. The ovary was received for histopathologic evaluation in multiple pieces among which a 1.1 cm firm tan nodule was identified. Histologically, this nodule composed of small glandular structures scattered in pools of mucin adjacent to a mature cystic teratoma. The glands were lined by goblet and columnar cells and showed no appreciable atypia. Immunohistochemistry revealed intense, diffuse staining pattern of the mucinous tumor component for CK20, CDX-2 and villin and focal patchy positivity for CK7 and chromogranin. Metastatic tumors from the GI tract and Krukenberg tumors were considered in this patient's differential diagnosis. She subsequently underwent a total abdominal hysterectomy with staging and appendectomy. However, no evidence of primary gastrointestinal malignancy or residual ovarian disease was found. The histologic and immunohistochemical characteristics of the tumor, its intimate association with a mature cystic teratoma and the absence of primary malignancy elsewhere are compatible with the diagnosis of a primary ovarian mucinous carcinoid tumor. This case is presented to raise the awareness of a rare tumor entity among the pathology and gynecologic communities.

show abstract

“…The large majority of primary ovarian carcinoids are unilateral, but in 16% of cases the contralateral ovary is involved by a cystic teratoma or a mucinous neoplasm (5) . In contrast, metastatic carcinoids are nearly always bilateral and scattered tumor deposits are present throughout both ovaries (6) . In the present case, the contralateral ovary and peritoneal surface appeared normal on US and during surgery.…”

Section: Case Historymentioning

confidence: 97%

Pierwotny rakowiak jajnika w obrębie dojrzałego potworniaka torbielowatego

Sahu

Agasti

Senapati

2016

Curr. Gynecol. Oncol.

View full text Add to dashboard Cite

Primary carcinoid tumor of the ovary in association with a mature cystic teratoma is very rare. Preoperative diagnosis of this tumor is difficult, particularly in the absence of symptoms of carcinoid syndrome. Here, we report a case of a premenopausal woman who underwent operative treatment due to an ovarian mass. The ovary was cystic with a solid mural nodule. Microscopically, the cyst wall revealed features of mature teratoma while the nodule showed features of a low-grade insular carcinoid. Synaptophysin and CD56 were positive. Ki67 index was low. No evidence of primary gastrointestinal or respiratory malignancy was found. The histologic and immunohistochemical characteristics of this tumor, its intimate association with a mature cystic teratoma and the absence of primary malignancy elsewhere were compatible with the diagnosis of a primary ovarian insular carcinoid tumor. This case is reported to raise the awareness of a rare tumor entity among the pathology and gynecologic communities.

show abstract

Mucinous carcinoid of the ovary: report of a case with metastasis in the contralateral ovary after ten years

Cited by 13 publications

References 9 publications

Clinicopathological analysis of primary carcinoid tumour of the ovary arising in mature cystic teratomas

Clinicopathological analysis of primary carcinoid tumour of the ovary arising in mature cystic teratomas

Primary Mucinous Carcinoid of the Ovary Arising in a Mature Cystic Teratoma: A Case Report with Review of the Literature

Pierwotny rakowiak jajnika w obrębie dojrzałego potworniaka torbielowatego

Contact Info

Product

Resources

About