Mucin-Secreting Adenocarcinoma of the Prostate with Neuroendocrine Differentiation and Paneth-Like Cells

W, Van de Voorde; H, Van Poppel; Haustermans, Karin; Baert, Luc; Lauweryns, Joseph M.

doi:10.1097/00000478-199402000-00010

Cited by 15 publications

(3 citation statements)

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“…Mucinous adenocarcinoma of the prostate is only rarely associated with true intracellular mucin positive ''signet ring cells'' unlike its counterparts in the bladder, urethra, or gastrointestinal tract. 1,13,14,17,29,34,36 Positive staining for PSA and prostate-specific acid phosphatase along with typically negative staining for CDX2 identifies the tumor as being of prostatic origin.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of Mucinous Adenocarcinoma of the Prostate Treated by Radical Prostatectomy

Osunkoya

Nielsen²,

Epstein³

2008

American Journal of Surgical Pathology

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Mucinous adenocarcinoma of the prostate is one of the least common variants of prostate cancer. The prognosis of this variant of prostate cancer remains controversial. We present 47 cases (1991 to 2006) of mucinous carcinomas treated by radical prostatectomy. Mean patient age at diagnosis was 56 years (range: 44 to 69 y). The mean preoperative prostate-specific antigen (PSA) level was 9.0 ng/mL (range: 1.9 to 34.3 ng/mL). Clinical stages were T1c (34 cases), T2a (7 cases), and T2b (6 cases). The mean percentage of tumor composed of the mucinous component was 52% (range: 25% to 90%). The mean Gleason score was 7 with scores of 6 in 6 cases (12.8%), 7 in 37 cases (78.7%), and 8 in 4 cases (8.5%). Margins were positive in 4 cases of mucinous adenocarcinoma of the prostate. Only 2 cases had isolated margin positivity in the nonmucinous acinar component of cancer. In 12 cases (25.5%), mucinous adenocarcinoma had established extraprostatic extension (EEPE). Eight cases (17.0%) had isolated EEPE of nonmucinous cancer. The 1 lymph node metastasis contained nonmucinous cancer. All together, taking into account both the mucinous and nonmucinous tumor, 20/47 cases (42.5%) had EEPE and 6/47 (12.7%) had positive margins. The 1 lymph node metastasis contained nonmucinous cancer. The mean follow-up for those without progression was 5.6 years (median 6 y, range: 1 to 15 y). One patient (2.1%) progressed 3 years after his radical prostatectomy (5 y actuarial progression-free risk 97.2%). Using the Kattan nomogram, the predicted mean 5-year PSA progression-free risk for nonmucinous prostate cancer with the same PSA and postoperative findings as in the current study was 85.4%. This study confirms that mucinous adenocarcinoma of the prostate treated by radical prostatectomy is not more aggressive, and possibly even less aggressive than nonmucinous prostatic adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Prognosis of Mucinous Adenocarcinoma of the Prostate Treated by Radical Prostatectomy

Osunkoya

Nielsen²,

Epstein³

2008

American Journal of Surgical Pathology

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“…Neuroendocrine and Paneth-like cells can be present. 29 Collagenous micronodules are often present ( Figure 6). Mucinous carcinoma is considered to be a Gleason grade 4 pattern.…”

Section: Mucinous (Colloid) Carcinomamentioning

confidence: 99%

Unusual subtypes of prostate cancer

2004

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The vast majority of prostatic tumors developing in adult males are adenocarcinomas. For the most part, variations in histology have not received specific designations and, from a practical approach, have had any specific prognostic implications handled through application of the Gleason grading system. Nonetheless, some of the adenocarcinoma variants have specific clinical features and differential diagnoses. Furthermore, there has been some controversy regarding the appropriate application of the Gleason grading scheme in these tumors. In addition, there are carcinomas that are in fact not adenocarcinomas and that should be kept as distinct entities. In this paper, the histologic variants of adenocarcinoma are reviewed with emphasis on clinicopathologic features and the clinical relevance of these subtypes. Other carcinomas that occur in the prostate gland are also discussed again with a focus on the clinicopathologic characteristics.

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“…Most reports have described tumour cells positive for endocrine markers indistinguishable from exocrine tumour cells [1,6,9,14], or showing large eosinophilic granules referred to as Paneth-like cells [2,17,[26][27][28]. The novelty of the current case is the presence, in a prostatic adenocarcinoma, of numerous basophilic and densely granulated cells which represent a light microscopically detectable, unusual, and so far undescribed form of endocrine differentiation, demonstrable by histochemical, immunohistochemical and electron microscopic techniques.…”

Section: Discussionmentioning

confidence: 83%

Unusual prostatic adenocarcinoma with endocrine basophilic FSH-immunoreactive cells

2000

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We report an unusual variant of prostatic adenocarcinoma with marked endocrine differentiation (mixed endocrine-exocrine adenocarcinoma). Endocrine cells accounted for 60% of the tumour cells, were positive with silver impregnation and for chromogranin A, synaptophysin, and neuron-specific enolase, and coexpressed the exocrine antigens prostatic acid phosphatase and prostatic-specific antigen. Most of the endocrine cells were basophilic with haematoxylin-eosin and proved immunoreactive for alpha subunit of human chorionic gonadotropin and follicle-stimulating hormone. The remaining endocrine cells were represented by eosinophilic cells positive for serotonin, and by calcitonin and serotonin-immunoreactive cells not identifiable in haematoxylin-eosin-stained sections. On ultrastructural analysis, two types of endocrine cells were identified. The most frequent cell type showed abundant cytoplasmic round, electron-dense neurosecretory granules, either small (212+/-44 nm) or large (471+/-114 nm), resembling those of gonadotropic pituitary cells. The second type of endocrine cells contained irregular electron-dense granules similar to those of serotonin-storing enterochromaffin cells.

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Mucin-Secreting Adenocarcinoma of the Prostate with Neuroendocrine Differentiation and Paneth-Like Cells

Cited by 15 publications

References 0 publications

Prognosis of Mucinous Adenocarcinoma of the Prostate Treated by Radical Prostatectomy

Prognosis of Mucinous Adenocarcinoma of the Prostate Treated by Radical Prostatectomy

Unusual subtypes of prostate cancer

Unusual prostatic adenocarcinoma with endocrine basophilic FSH-immunoreactive cells

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