Mucin Protein of Aedes aegypti Interacts with Dengue Virus 2 and Influences Viral Infection

Yadav, Karuna; Rana, Vipin Singh; Anjali, .; Saurav, Gunjan Kumar; Rawat, Nitish; Kumar, Ankit; Sunil, Sujatha; Singh, Om Prakash; Rajagopal, Raman

doi:10.1128/spectrum.02503-22

Cited by 1 publication

(1 citation statement)

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“…Additionally, mucin protein was identified to be localised in Ae. Aegypti 's midgut [17] . Although A. hydrophila's strong pathogenic potential has been demonstrated, its survival and multiplication methods against the immune system of the host remain little understood.…”

Section: Resultsmentioning

confidence: 99%

Identification of the efficiency of Pentane on the bacterial and insecticide proteins of Aedes aegypti and Aeromonas hydrophila by Insilico methods

Astalakshmi,

John,

et al. 2023

Int. J. Mosq. Res.

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Aedes aegypti is known to spread diseases by acting as a vector for Yellow fever virus, Dengue virus, Chikungunya virus, and Zika virus. Aeromonas hydrophila is a bacillus with a monotrichous flagellum which is gram-negative, pleomorphic and non-spore-forming. It is a facultative anaerobe that is commonly present in both fresh water and sewage. In this research study, we found out the efficiency of the chemical molecule, Pentane (Phyllanthus emblica) on the above two species. From the comparative study, we analyse the anti-microbial and Insecticide properties of Pentane using insilico protocol. The methodology of this study involved protein profiling studies and automated drug docking protocols. All the results were elucidated in 3D form. The complete molecular interaction study clearly elucidated the efficiency of the molecular compound, Pentane with the target proteins, Mucin-5AC and the Outer Membrane Protein Transport Protein of Aedes aegypti and Aeromonas hydrophila respectively. It was finally concluded that Pentane had better inhibitive action on Aeromonas hydrophila than on Aedes aegypti. Hence, Pentane acts as a potential therapeutic agent for diseases associated with Aeromonas hydrophila.

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Section: Resultsmentioning

confidence: 99%