Mucin-producing bile duct carcinoma originating at the hepatic hilus

Hirota, Masahiko; Tomioka, Takahiro; Ohshima, Hisami; Yamasaki, Katsumi; Matsuo, Takashi; Atari, Eio

doi:10.1007/bf01211356

Cited by 2 publications

(4 citation statements)

References 18 publications

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“…In fact, no MPBTs in our series had lymph node involvement (Table 1) or neural invasion. In contrast, MPBTs invading beyond the ductal wall seem to be associated with lymph node metastasis or neural invasion with almost the same frequency as that seen in other types of bile duct carcinomas [9, 12].…”

Section: Clinicopathologic Features and Modes Of Spreadmentioning

confidence: 99%

“…Few reports have described the recurrence of MPBTs after surgical resection [1, 9, 12]. Local, peritoneal, and hepatic recurrences have been observed in patients with MPBT invading beyond the ductal wall.…”

Section: Follow Upmentioning

confidence: 99%

“…Remote metastases are rare in patients with MPBT. Besides hepatic and splenic recurrence after surgical resection [12], tumor seeding in the sinus tract of percutaneous transhepatic biliary drainage (PTBD) has been reported to be a characteristic recurrence site in this tumor [9].…”

Section: Clinicopathologic Features and Modes Of Spreadmentioning

confidence: 99%

“…Once MPBTs invade beyond the ductal wall, lymph node metastasis and invasion into adjacent organs such as the stomach and the pericardium occurs, and the outcome in these patients is not always favorable. Hirota et al [12] have reported a case in which the cancer, initially with lymph node metastasis, recurred in the liver and spleen 24 months after surgical resection. Sakamoto et al [9] have also reported that a patient with invasive MPBT died 6 months after surgical resection.…”

Section: Surgical Outcomementioning

confidence: 99%

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Surgical strategy for mucin‐producing bile duct tumor

Ohtsuka

Kimura

Shimizu

et al. 2009

J Hepato Biliary Pancreat

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Tumors with copious mucin production within the intra‐ or extrahepatic bile ducts have been reported as mucin‐producing bile duct tumors (MPBTs). Because mucin produced by these tumors causes recurrent cholangitis and obstructive jaundice, surgical resection should be indicated even if these tumors are regarded as benign. In order to choose the appropriate surgical procedure, exact preoperative assessment of tumor location and cancer extension is important, especially evaluation of the extent of superficial spreading through cholangioscopic observation and biopsy. In principle, MPBTs should be resected in a manner similar to that employed for other types of bile duct carcinomas. That is, major hepatectomy with or without extrahepatic bile duct resection or pancreaticoduodenectomy should be chosen as the surgical procedure, and intraoperative frozen section at the stumps of the bile duct is essential. On the other hand, when precise diagnosis is completed preoperatively and the lesion is diagnosed as adenoma or carcinoma with invasion confined to the ductal wall and limited superficial spreading, limited resections preserving organ functions as much as possible can be considered as a choice among surgical procedures. All ten patients with MPBT resected at our institution according to these strategies are still alive without tumor recurrence, with a median survival of 48.0 months.

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Section: Clinicopathologic Features and Modes Of Spreadmentioning

confidence: 99%

Section: Follow Upmentioning

confidence: 99%

Section: Clinicopathologic Features and Modes Of Spreadmentioning

confidence: 99%

Section: Surgical Outcomementioning

confidence: 99%

See 2 more Smart Citations

Surgical strategy for mucin‐producing bile duct tumor

Ohtsuka

Kimura

Shimizu

et al. 2009

J Hepato Biliary Pancreat

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Mucin Ball-producing Extrahepatic Bile Duct Carcinoma

Kenjo

Abe²,

Saito³

et al. 2000

Scandinavian Journal of Gastroenterology

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The characteristic features of surgically curable mucin-producing extrahepatic bile duct carcinoma (MPEBC) have not previously been elucidated. Three (6.5%) of 46 patients who underwent surgery in our department for bile duct carcinoma between 1986 and 1997 had MPEBC. Clinicopathological features, diagnostic procedures and operative methods for patients with MPEBC were investigated. Tumors in the bile duct were identified by cholangioscopy combined with cholangiography after removal of mucin balls. Tumors were located close to the hepatic confluence in these patients. Two patients underwent hepatic lobectomy together with caudate lobectomy while the other underwent resection of the hepatic confluence. Absence of residual tumors was confirmed histologically in these patients. All three patients remain alive without evidence of recurrence, 22-54 months after surgery. MPEBC is a curable disease. Accurate localization in the biliary tree is essential and can only be obtained after, i) removal of mucin balls, and ii) extensive diagnostic work-up including cholangiography, cholangioscopy and intraoperative pathological examination.

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Mucin-producing bile duct carcinoma originating at the hepatic hilus

Cited by 2 publications

References 18 publications

Surgical strategy for mucin‐producing bile duct tumor

Surgical strategy for mucin‐producing bile duct tumor

Mucin Ball-producing Extrahepatic Bile Duct Carcinoma

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