Mucin in benign thyroid nodules: treatment related change or not?

Handra-Luca, Adriana

doi:10.1186/s13044-019-0062-4

Cited by 1 publication

(3 citation statements)

References 5 publications

(5 reference statements)

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“…Decreased thyroid hormones (T3 and T4) can lead to increased atherogenic markers total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) ( Wanjia et al, 2012 ). TSH level may increase with age ( Bremner et al, 2012 ; Leng and Razvi, 2019 ). Due to the low individuality index of TSH, it is not possible to determine an accurate TSH upper limit at the individual level from population data.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the low individuality index of TSH, it is not possible to determine an accurate TSH upper limit at the individual level from population data. With the current upper limit of the serum TSH reference range in the elderly, overdiagnosis of hypothyroidism is possible ( Leng and Razvi, 2019 ). In addition to levels of thyroid hormones, particularly free T4, other studies are needed to define an age-specific TSH reference range as part of clinical practice ( Bremner et al, 2012 ; Leng and Razvi, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…With the current upper limit of the serum TSH reference range in the elderly, overdiagnosis of hypothyroidism is possible ( Leng and Razvi, 2019 ). In addition to levels of thyroid hormones, particularly free T4, other studies are needed to define an age-specific TSH reference range as part of clinical practice ( Bremner et al, 2012 ; Leng and Razvi, 2019 ). In the current study, the levels of thyroid hormones were not measured.…”

Section: Discussionmentioning

confidence: 99%

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The Effects of Elaeagnus angustifolia L. on the Thyroid-Stimulating Hormone, Dehydroepiandrosterone-Sulfate, Prolactin and Cortisol Levels in Post-Menopausal Women: A Double-Blind, Randomized, and Placebo-Controlled Study

Jalalvand

Rezaei

Badehnoosh³

et al. 2021

Front. Pharmacol.

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Menopause is the last menstrual period associated with a decline in ovarian steroid secretion and follicular loss. Hormone profile changes during menopause include a decrease in the production of estrogen, dehydroepiandrosterone (DHEA), and prolactin (PRL), and an increase in thyroid-stimulating hormone (TSH) and cortisol. Herbal medicines are considered as alternatives to hormone therapy. The studies on postmenopausal women have shown that Elaeagnus angustifolia L. (called “Senjed” in Persian) has some efficacy in improving sex hormone and lipid profiles, joint pain, and cardiovascular function, as the decrease in luteinizing hormone, low-density lipoprotein, and heart rate was significant. The aim of the present study was to evaluate the effects of E. angustifolia on TSH, DHEA-S, PRL, and cortisol levels and their ratios in postmenopausal women. It is assumed that the eventual effects of hormones on the brain and other tissues are determined by the balance between interdependent hormones. In the present randomized double-blinded placebo-controlled trial (https://en.irct.ir/search/result?query=IRCT20170227032795N4), fifty-eight postmenopausal women were randomly assigned to one of two medicinal herb (15 g of the whole E. angustifolia fruit powder) and placebo (7.5 g isomalt + 7.5 g cornstarch) groups. After 10 weeks of the treatment, the serum levels of TSH, DHEA-S, PRL, cortisol hormones, and their ratios were measured. The increase in the TSH, and cortisol levels, and cortisol/DHEA-S ratio and the decrease in prolactin and DHEA-S and the PRL/TSH, PRL/cortisol, and DHEA-S/TSH ratios after E. angustifolia consumption were significant only based on within-group but not on the between-group analysis. Based on between-group analyses, the changes in the hormone profile were not significant in the placebo group. According to Iranian tradition and folklore, E. angustifolia fruit is a symbol of female fertility. Therefore, its consumption is highly recommended to maintain health in the elderly, especially women. However, the observed outcomes about the effect of E. angustifolia on menopause were not completely in line with the Iranian folklore. E. angustifolia consumption did not significantly affect the hormone profile and ratios at the end of the ten-week trial, possibly due to the small sample size, short time, and the fact that our participants were postmenopausal women.

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Section: Discussionmentioning

confidence: 99%