Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome

Werther, J. Lawrence; Rivera-MacMurray, S; Bruckner, Howard W.; Tatematsu, M; Itzkowitz, SH

doi:10.1038/bjc.1994.114

Cited by 60 publications

(49 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A low frequency of positive STn expression has been reported for cancers of the breast, duodenal ampulla and common bile duct, while more than half of the adenocarcinomas of the stomach, pancreas, gallbladder, colorectum, ovary and uterus express STn [14]. The reported rate of STn expression in gastric and colorectal carcinomas is between 62 and 90% [10, 14, 15, 16, 17, 18, 19]. …”

Section: Introductionmentioning

confidence: 99%

STn and Prognosis in Breast Cancer

Leivonen

Nordling²,

Lundin

et al. 2001

Oncology

View full text Add to dashboard Cite

Sialyl-Tn (STn) is a carbohydrate antigen formed by the premature 2–6 sialylation of N-acetylgalactosamine. It belongs to a family of antigens widely expressed in carcinomas but only to a limited degree in normal tissue. The expression of STn has been associated with prognosis in different tumors. In this immunohistochemical study of 218 patients with invasive stage I–III breast cancer, STn was expressed in 39% of the tumors. High expression of STn correlated with estrogen and progesterone hormone receptor negativity (p = 0.0002 and p = 0.0003, respectively), and marginally with large tumor size (p = 0.04), high S-phase fraction (p = 0.04) and aneuploidy (p = 0.04), but not significantly with node status, grade or age. The patients had a median follow-up of 17 years. The breast-cancer-specific survival rate of patients with STn-negative cancers was higher than that of patients with cancers that expressed STn during the first 5 years of the follow-up (p = 0.013), but the difference between the groups decreased during the long-term follow-up. STn expression seems to be a marker for short-term, but not for long-term breast cancer outcome prediction.

show abstract

Section: Introductionmentioning

confidence: 99%

STn and Prognosis in Breast Cancer

Leivonen

Nordling²,

Lundin

et al. 2001

Oncology

View full text Add to dashboard Cite

show abstract

“…The sialylation of GalNAc prevents further sugar additions and effectively truncates the O-linked glycan extension [20,21]. Given that antibodies against STn are cancer specific [17,22], serum STn levels are used as a prognostic indicator for cancer aggressiveness and metastatic potential [23][24][25] in colorectal [26] and ovarian cancer [13].…”

Section: Introductionmentioning

confidence: 99%

RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells

et al. 2014

View full text Add to dashboard Cite

Background ST6GalNAc I is a sialyltransferase controlling the expression of sialyl-Tn antigen (STn), which is overexpressed in several epithelial cancers, including gastric cancer, and is highly correlated with cancer metastasis. However, the functional contribution of ST6GalNAc I to development or progression of gastric cancer remains unclear. In this study, we investigated the effects of suppression of ST6GalNAc I on gastric cancer in vitro and in vivo. Methods Gastric cancer cell lines were transfected with ST6GalNAc I siRNA and were examined by cell proliferation, migration, and invasion assays. We also evaluated the effect of ST6GalNAc I siRNA treatment in a peritoneal dissemination mouse model. The differences in mRNA levels of selected signaling molecules were analyzed by polymerase chain reaction (PCR) arrays associated with tumor metastasis in MKN45 cells. The signal transducer and activator of transcription 5b (STAT5b) signaling pathways that reportedly regulate the insulin-like growth factor-1 (IGF-1) were analyzed by Western blot.

show abstract

“…However, no sufficient data are available concerning the association of certain histological subtypes with the expression of these antigens. Additionally, the relation between mucin peptide core expression and prognosis of gastric carcinomas has not been investigated, although recent results have documented a prognostic impact of mucin-associated carbohydrate antigens such as sialosyl-Tn and T antigen as well as sialosyl-Lewis a (Werther et al, 1994;Kakeji et al, 1995;Chung et al, 1996;Victorzon et al, 1996;Nakamori et al, 1997).…”

mentioning

confidence: 99%