Mucin-7 as a Potential Candidate Risk Allele for Cleft Lip and/or Palate
Rachel A. Montel,
Tatiana P. Rengifo,
Sulie L. Chang
Abstract:Cleft lip and/or palate (CL/P) occur in approximately 1 in 700 live births in the United States. High hereditary rates (50-80%) of CL/P indicate a strong genetic cause. The concept of strong genetic causes has been well-demonstrated in previous studies such as GWAS studies that identified IRF6 for Van der Woode syndrome. Since the risk for genetic factors is strongly associated with CL/P, we hypothesized that RNA sequencing (RNA-seq) from CL/P patients may reveal enriched genes. Differential expression analysi… Show more
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