Mucin 5B in saliva and serum of patients with oral lichen planus

Agha‐Hosseini, Farzaneh; Imanpour, Mojtaba; Mirzaii‐Dizgah, Iraj; Moosavi, Mahdieh‐Sadat

doi:10.1038/s41598-017-12157-1

Cited by 22 publications

(23 citation statements)

References 28 publications

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“…The unstimulated and stimulated saliva flow rates were significantly lower in OLP patients compared with controls, and the severity of xerostomia was significantly higher in OLP patients compared with controls. These findings, in line with the results of some previous studies, highlighted the presence of xerostomia and decreased salivary flow rate in OLP patients 5,8,21,22 . A previous study showed that altered composition of saliva (Mucin 5b) in OLP patients may lead to xerostomia 5 …”

Section: Discussionsupporting

confidence: 92%

“…Another study assessed the level of salivary 5B mucin, which is responsible for moisture and lubrication of the oral cavity in OLP patients and healthy controls. The results showed that the level of salivary 5B mucin was significantly lower in OLP patients compared with healthy controls 5 . To better understand the pathogenesis of xerostomia in OLP, this study aimed to assess and compare the level of M3 muscarinic receptors in minor salivary glands of OLP patients and healthy controls.…”

Section: Introductionmentioning

confidence: 97%

“…Its exact etiology is not known; however, factors such as medication intake, viral antigens, chemical agents, genetics, and immunological factors may play a role in its occurrence 3 . OLP is among the main topics of dental research due to its high prevalence in the oral mucosa, symptomatic nature even in reticular cases (sense of roughness), unknown etiopathogenesis and triggering factors, absence of definite treatment for it, susceptibility to malignant transformation with no known reason, and recently, its association with xerostomia 4‐6 …”

Section: Introductionmentioning

confidence: 99%

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Muscarinic cholinergic receptors in minor salivary gland tissues of patients with oral lichen planus: A case‐control study

Agha‐Hosseini

Moosavi

Mirzaii‐Dizgah

et al. 2020

J Oral Pathology Medicine

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Background Oral lichen planus (OLP) is a common, chronic immunological and inflammatory condition. Many of the OLP patients complain of xerostomia. The M3 muscarinic cholinergic receptors (MR3) are the main receptors in the salivary glands responsible for water secretion into the saliva. This study aimed to assess the level of M3 muscarinic cholinergic receptors in minor salivary glands of OLP patients. Methods This case‐control cross‐sectional study evaluated 40 OLP patients and 22 controls. All participants completed two questionnaires (xerostomia and xerostomia inventory). Stimulated and unstimulated saliva samples were collected. The saliva flow rate was calculated by dividing the saliva volume (in milliliters) by time (in minutes). Six minor salivary glands were also surgically removed from the lower lip of patients and controls, and weighed using a digital scale with 10−4 g accuracy. They were then frozen at −80°C, and the level of M3 receptors of the glands was determined using the ELISA kit. Results The unstimulated and stimulated saliva flow rate was significantly lower in OLP patients. The xerostomia inventory score was significantly higher in the OLP group. The level of M3 muscarinic receptors in minor salivary glands of OLP patients was significantly higher than that in controls. Conclusions It may be concluded that the reduction in saliva flow significantly increases the number of M3 receptors in an attempt to compensate for this shortage and prevent xerostomia (compensatory upregulation).

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Muscarinic cholinergic receptors in minor salivary gland tissues of patients with oral lichen planus: A case‐control study

Agha‐Hosseini

Moosavi

Mirzaii‐Dizgah

et al. 2020

J Oral Pathology Medicine

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“…In OLP, the patients with reticular or plaque-like forms tend to be asymptomatic [34] although atrophic and erosive lesions cause severe symptoms [29,38,39]. The main symptoms caused by the erosive, atrophic, and bullous forms in either OLP or lichenoid lesions include pain, soreness, and bleeding; the combination of these symptoms can affect the quality of life of the patients [4,18]. Dry mouth has been reported in LP patients [40].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Oral lichen planus (OLP) is a common chronic and recurrent immunologic inflammatory mucocutaneous disorder with unspecified etiology [1][2][3]. Recent data have attributed the etiopathogenesis to cell-mediated immune responses [4]. In contrast, lichenoid reactions are lesions with known etiology that may be clinically and histologically very similar to LP; this makes it difficult to differentiate these two entities [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

Agha‐Hosseini

Samami

Tavakol

et al. 2019

J Islam Dent Assoc Iran

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Background and Aim: Oral lichen planus (OLP) is a chronic, inflammatory, T-cellmediated autoimmune oral mucosal disease. Oral lichenoid lesions develop as a type IV hypersensitivity reaction. Both of these entities are potential precancerous conditions; this adds to their clinical significance. The purpose of this literature review was to detect the similarities and the differences of these lesions to enhance the information of colleagues in managing these groups of patients. Materials and Methods: For this review, we searched Cochrane, Medline, and Embase databases from January 1990 to the end of October 2018. A total of 96 published papers, including review papers, case reports, cohort studies, case-control studies, and meta-analysis studies, were included and analyzed. Results: OLP and oral lichenoid reactions are two distinct diseases. They can be clinically similar but they have different etiologic factors. A histopathological study is necessary to differentiate them. Conclusion: The definitive diagnosis of these conditions is extremely important given their potentially premalignant nature. A timely diagnosis probably results in proper management. Based on the present research, the final differentiation between OLP and oral Lichenoid reactions relies on both clinical and histopathological manifestations according to the modified World Health Organization (WHO) criteria.

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Patients with oral lichen planus display lower levels of salivary acidic glycoproteins than individuals without oral mucosal disease

Çevik‐Aras,

Musa,

Olofsson

et al. 2023

Clin Oral Invest

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Objectives Salivary proteins, acidic glycoproteins, and free calcium might take part in oral mucosal defence against inflammation in oral lichen planus (OLP). The study aimed to investigate whether the levels of sulfated and sialylated glycoproteins, total protein, and free calcium in saliva from patients with OLP differ from those of individuals without oral mucosal diseases. Material and Methods Patients diagnosed with OLP (n = 25) and two control groups without any oral mucosal disease; age- and gender-matched controls (n = 25, 65.6 ± 2.9 years), and younger controls (n = 25, 41.8 ± 2.5 years) were included. Subjective dry mouth (xerostomia) was assessed by asking a single-item question. Chew-stimulated whole saliva was collected to measure sulfated and sialylated glycoproteins by the Alcian Blue method. The total protein was determined spectrophotometrically, and the free calcium measured using an electrode. Results The output of salivary sulfated and sialylated glycoproteins in the OLP group (21.8 ± 2.4 µg/min) was lower than in the age- and gender-matched controls (43.0 ± 2.9 µg/min, p = 0.0002), whereas the total protein and calcium output did not differ between the three groups (p > 0.05). The prevalence of xerostomia was significantly higher in the OLP group compared to both control groups (p = 0.038). Conclusions Patients with OLP showed a high prevalence of xerostomia and lower levels of salivary acidic type glycoproteins compared to the individuals without oral mucosa disease. Clinical relevance It is relevant to investigate the role of acidic glycoproteins in the pathogenesis of OLP.

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Mucin 5B in saliva and serum of patients with oral lichen planus

Cited by 22 publications

References 28 publications

Muscarinic cholinergic receptors in minor salivary gland tissues of patients with oral lichen planus: A case‐control study

Muscarinic cholinergic receptors in minor salivary gland tissues of patients with oral lichen planus: A case‐control study

Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

Patients with oral lichen planus display lower levels of salivary acidic glycoproteins than individuals without oral mucosal disease

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