Mucha‐Habermann Disease in a Child: Possible Association with Measles Vaccination

Abstract

A 2.5-year-old boy presented with skin lesions consistent with Mucha-Habermann disease, which appeared about 5 days after an injection of freeze-dried live attenuated measles vaccine. He responded to both oral and topical corticosteroid therapy. To my knowledge, this represents the first such association of Mucha-Habermann disease with virus vaccination.

Pityriasis lichenoides and its subtypes

“…In 1992 Torinuki reported the occurrence of PLEVA in a 2.5-year-old boy 5 days after an injection of freeze-dried live attenuated measles vaccine. 85 To our knowledge, this is the only reported case of pityriasis lichenoides in association with virus vaccination.…”

Febrile ulceronecrotic Mucha-Habermann disease with clonality: A cutaneous T-cell lymphoma entity?

“…7 Here, we report that two patients with PLEVA developed a fulminant course of the disease with widespread erosions and ulcerations, as first described by Degos et al 8 A review of the literature reveals 23 cases of FUMHD. 1,2,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Including our cases, the lethality of FUMHD is approximately 24% (6 of 25 patients). Nineteen patients recovered using a variety of therapeutic regimens such as systemic corticosteroids, 2,9-16,18-21 dimethylsulfone (DDS), 18,21 MTX, 1-3,13,21 antibiotics, 1,2,8,10,11,13-21 PUVA, 2,11 acyclovir, 16,17 and debridement and skin grafting.…”

Pityriasis lichenoides et varioliformis acuta: A rare association with the measles, mumps and rubella vaccine

“…Some people may develop a transient viral exanthem 3 . To our knowledge, there has only been one other reported case of PLEVA in association with vaccination 4 …”