MUC1 oncogene amplification correlates with protein overexpression in invasive breast carcinoma cells

Lacunza, Ezequiel; Baudis, Michael; Colussi, A.; Segal‐Eiras, Amada; Croce, María Virginia; Abba, Martı́n C.

doi:10.1016/j.cancergencyto.2010.05.015

Cited by 42 publications

(23 citation statements)

References 38 publications

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“…CA 15-3 is the protein product of the MUC1 gene [ 7 ]. In normal mammary tissue, it is a membrane-associated glycoprotein mainly expressed at the apical side of the glandular epithelial cells in alveoli and mammary ducts [ 8 ].…”

Section: Ca 15-3mentioning

confidence: 99%

Sensitivity of CA 15-3, CEA and serum HER2 in the early detection of recurrence of breast cancer

Pedersen

Sørensen

Jacobsen

et al. 2013

Clinical Chemistry and Laboratory Medicine

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Section: Ca 15-3mentioning

confidence: 99%

Sensitivity of CA 15-3, CEA and serum HER2 in the early detection of recurrence of breast cancer

Pedersen

Sørensen

Jacobsen

et al. 2013

Clinical Chemistry and Laboratory Medicine

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“…It is a transmembrane glycoprotein encoded by the MUC1 gene, defined by reactivity with two monoclonal antibodies, DF3 and 115-D8, in a sandwich immunoassay [2]. MUC1 gene is involved in cell adhesion, reducing cell to cell aggregation, and cell adherence to extracellular matrix [3], induces an immunosuppressive action [4][5][6] and therefore facilitates metastasis formation [7,8]. It is heterogeneously expressed on the apical surface of different normal epithelial cell types, but it is aberrantly overexpressed in 90% of breast cancer [9].…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of CA15.3 in 7942 patients with operable breast cancer

Sandri

Salvatici

Botteri

et al. 2011

Breast Cancer Res Treat

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To assess the prognostic value of presurgical CA15.3 in a large cohort of patients with early breast cancer. A total of 7.942 consecutive patients with breast cancer operated at the European Institute of Oncology between 1998 and 2005 and with presurgical values of CA 15.3 available were included. We explored patterns of recurrence by baseline CA 15.3 values. Mean CA15.3 was 17.0 U/ml. CA15.3 was associated with age, tumor size, nodal involvement, Ki-67 labeling index, grade, HER2 expression, molecular subtype, and perivascular invasion. CA15.3 was independently associated with distant metastases [HR > 20 U/ml vs. ≤ 20 U/ml: 1.34 (95% CI 1.15-1.56)] and death [HR > 20 U/ml vs. ≤ 20 U/ml: 1.30 (95% CI 1.11-1.53)]. When considering CA15.3 as continuous variable, we observed a constant risk of metastasis and death from the lowest values to about 15-20 U/ml, and then a significantly increasing risk with increasing values of CA15.3. Finally, CA15.3 provided significant additional information to the common prognostic factors to predict the occurrence of metastases (C-index P value 0.04). In patients with operable breast cancer, presurgical CA15.3 value is an independent prognostic factor for metastases and deaths. CA15.3 provides additional information to the common prognostic factors and should be considered in the adjuvant therapeutic algorithm.

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“…MUC1 gene amplification also correlated significantly with protein expression, indicating that MUC1 gene amplification may be an untapped and important source for MUC1 protein in breast cancer samples, and that amplification of MUC1 may select cells for metastatic progression. 64 MUC1 expression and corresponding metastatic phenotypes are also regulated at the post-transcriptional level by microRNAs. Two miRs have been identified to regulate MUC1 translation, including miR-125b, which is upregulated by androgen receptor, and miR-145.…”

Section: Muc1 Expression Correlates With Metastasismentioning

confidence: 99%

“…Examination of 83 patients for MUC1 gene amplification and protein expression found that 12% of benign lesions and 38% of primary invasive breast carcinoma samples displayed MUC1 genomic amplification. 64 Furthermore, meta-analysis of 886 primary invasive breast carcinoma samples from 22 studies demonstrated that 44% had genomic gain of the MUC1 gene. MUC1 gene amplification also correlated significantly with protein expression, indicating that MUC1 gene amplification may be an untapped and important source for MUC1 protein in breast cancer samples, and that amplification of MUC1 may select cells for metastatic progression.…”

Section: Muc1 Expression Correlates With Metastasismentioning

confidence: 99%