MUC1 and MUC2 expression in human gallbladder carcinoma: A clinicopathological study and relationship with prognosis

Kashiwagi, Hirokazu; Kijima, Hiroshi; Dowaki, Shoichi; Ohtani, Yasuo; Tobita, Kosuke; Yamazaki, Hitoshi; Nakamura, Masato; Ueyama, Yoshito; Tanaka, Makiko; Inokuchi, Sadaki; Makuuchi, Hiroyasu

doi:10.3892/or.8.3.485

Cited by 25 publications

(27 citation statements)

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“…The molecule was first identified in human milk, as a large molecular weight glycoprotein rich in serine, threonine and proline carrying a high percentage of O-linked carbohydrate [5] . MUC1 is widely expressed by normal glandular epithelial cells, and the expression is dramatically increased when the cells become malignant [6,7] , and its relationship with the prognosis of several carcinomas have been already reported [4,[8][9][10][11] . Changes in the expression levels of MUC1 have also been described in esophageal lesions [12] .…”

Section: Discussionmentioning

confidence: 99%

Expression of MUC1 in esophageal squamous-cell carcinoma and its relationship with prognosis of patients from Linzhou city, a high incidence area of northern China

Song

Gao²,

Yi³

et al. 2003

WJG

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AIM:To further characterize the possible relationship between the molecular changes and prognosis of ESC and to elucidate the possible mechanisms involved. METHODS:114 specimens of ESC were collected from Linzhou city, and all patients were followed up for more than 5 years after resection. Histopathological analysis and immunohistochemical staining (ABC) were employed to detect the alteration of MUC1. RESULTS:The positive immunostaining rate for MUC1 was 79 % (90/114), and the high-expression rate was 63 % (72/114). The mean survival periods (months) of those with high-and low-expression rates of MUC1 were 41 (95 % CI: 35, 47) and 52 (95 % CI: 45, 59), respectively. Patients in the low-expression group obviously survived longer than those in high-expression group, and the difference was significant (P<0.05). The expression of MUC1 protein in the esophageal carcinoma specimens with metastasis was stronger than those without metastasis, the difference was also significant (P<0.05). The stepwise multivariate analysis showed that "differentiation", "expression of MUC1" and "TNM staging" were the most important factors affecting the prognosis of esophageal carcinoma patients (P<0.05). CONCLUSION:A good correlation between the alteration of MUC1 and the regional lymph node metastasis was observed. Furthermore, high-expression of MUC1 was associated with poor prognosis for esophageal cancer patients. These results indicated that MUC1 is a promising biomarker for predicting lymph node metastasis and prognosis in esophageal cancer.

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Section: Discussionmentioning

confidence: 99%

Expression of MUC1 in esophageal squamous-cell carcinoma and its relationship with prognosis of patients from Linzhou city, a high incidence area of northern China

Song

Gao²,

Yi³

et al. 2003

WJG

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“…14 Compared to non-neoplastic tissue, however, tumor-associated MUC molecules are commonly underglycosylated, which may lead to a demasking of the peptide antigens facilitating their immunohistochemical detection. 15,16 Nevertheless, over expression of MUC1 in cancer tissues has been associated with poor prognosis in gastrointestinal adenocarcinomas, 15,[17][18][19][20][21][22] esophageal squamous cell carcinomas, 23 endometrial adenocarcinomas, 24 and non-small-cell lung cancers. 25 In breast cancer, the situation seems to be more complex.…”

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confidence: 99%

Expression of MUC1 (EMA) and E-cadherin in renal cell carcinoma: a systematic immunohistochemical analysis of 188 cases

et al. 2003

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MUC1 (epithelial membrane antigen) is a membrane-associated mucin known to interfere with both cell-cell and cell-matrix adhesions. Overexpression has been associated with poor prognosis in a variety of cancers. We investigated the expression of MUC1 (using two different antibodies, MA695 and E29) and E-cadherin in renal cell carcinomas (137 conventional, 23 chromophobe, 20 papillary, and eight unclassified tumors) with respect to diagnostic and prognostic significance using a tissue microarray technique. Immunoreactivity was correlated with histological subtype, pT-stage, and grade using the v 2 test or the Fisher's exact test, respectively. Impact on disease-free survival was analyzed using the Kaplan-Meier method and the log-rank test. Immunoreactivity of more than 10% of cancer cells with MA695, E 29, and E-cadherin antibodies was found in 112/133 (84%), 86/133 (65%), and 7/131 (5%) conventional, 20/22 (91%), 19/22 (86%), and 21/22 (95%) chromophobe, 13/20 (65%), 8/20 (40%), and 3/20 (15%) papillary as well as 5/8 (63%), 5/8 (63%), and 4/8 (50%) unclassified carcinomas, respectively. The two different MUC1 antibodies yielded comparable staining results. A diffuse cytoplasmic staining pattern for MUC1 was found exclusively in chromophobe carcinomas, whereas conventional and papillary subtypes showed predominantly membranous staining (Po0.0001). Regarding papillary carcinomas, MUC1 was predominantly associated with type 1 (P ¼ 0.0001), and E-cadherin with type 2 (P ¼ 0.049) tumors. The cellular staining pattern of MUC1 in conventional tumors was related to pT-stage (P ¼ 0.002) and tumor grade (P ¼ 0.001): Low-stage (pT1/pT2) and grade (G1/G2) tumors showed a predominantly apical membranous staining, high-stage (pT3a/pT3b) and grade (G3/G4) tumors a predominantly circumferential membranous staining (with or without additional diffuse cytoplasmic immunoreactivity), which, in the conventional subtype, was associated with poor prognosis (Po0.0001). In conclusion, MUC1 and E-cadherin are diagnostically and prognostically useful markers in renal tumor pathology, especially when cellular staining patterns are considered. Keywords: kidney; cancer; MUC1; EMA; E-cadherin; differential diagnosis; prognosisMucins are high-molecular-weight (4200 kDa) glycoproteins with oligosaccharides attached to an apomucin protein backbone (core peptide) by Oglycosidic linkage.

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“…This is the first report to demonstrate biliary type/MUC1 expression as indicators of aggressiveness of GBC. Several studies have reported prognostic significance of histological phenotype and mucin expression in GBC (3,9,10,21,25). However, the correlation between the histological phenotype/mucin expression and wall-invasion pattern has not yet clarified.…”

Section: Histological Phenotype and Clinicopathological Factors Of Gbcmentioning

confidence: 99%

Histological phenotype is correlated with the wall-invasion pattern of gallbladder adenocarcinoma

et al. 2014

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Gallbladder carcinoma (GBC) is one of the most aggressive malignancies, and frequently shows vascular invasion and lymph node metastasis. Our previous study has classified the wall-invasion pattern of GBC into two groups, i.e., infiltrative growth type (IG type) and destructive growth type (DG type). The DG type was significantly associated with poor clinical outcome. In this study, we analyzed the relationship between the wall-invasion pattern and the histological phenotype of GBC, using 61 surgically-resected primary gallbladder adenocarcinomas. Histologically, the 61 cases were classified into the biliary (44 cases, 72.1%), gastric foveolar (13 cases, 21.3%), and intestinal (4 cases, 6.6%) types. Biliary type frequently exhibited MUC1, but less frequently showed MUC2, MUC5AC, and MUC6. The biliary type and MUC1 expression were significantly correlated with DG type wall-invasion pattern (P = 0.020 and P < 0.001, respectively). In conclusion, histological phenotype and mucin expression were thought to be indicators of aggressiveness of GBC.Gallbladder carcinoma (GBC) is the most common malignancy of the biliary tract and the fifth most common malignancy of the digestive system. GBC is a relatively uncommon neoplasm in the majority of countries, and its incidence rate shows marked geographic and ethnic variation. Japan and several Latin American countries, such as Chile, Mexico and Bolivia, have the highest incidences of GBC in the world (11,27). In Japan, GBC is responsible for 1.25% and 3.49% of cancer death in male and female, respectively. The number of surgically resected cases of GBC has recently increased because of advances in imaging diagnosis and operative procedures. However, GBC is a highly lethal disease since it is usually diagnosed at advance stage (5).The 5-year survival rate of patients with GBC is 10-30% despite of surgical resection. Moreover, the majority of patients have frequent recurrences after the surgery, and pursue the chemotherapy or radiotherapy treatment when recurrences happened after the surgery (2, 15). Several previous studies have demonstrated high risks of disease progression, using surgically-resected GBC cases, and histological grade, depth of wall infiltration, and lymph node status have been determined to be clinicopathological prognostic factors (6,22). In addition, we have classified the wall-invasion pattern of GBC into two groups, i.e., infiltrative growth type (IG type) and destructive growth type (DG type) (18)(19)(20). The DG type was significantly associated with lymph node metastasis and poor prognosis. In this study, we analyzed the relationship between the wall-invasion pattern and the histological phenotype of GBC, using 61 surgically-resected primary gallbladder adenocarcinomas.

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MUC1 and MUC2 expression in human gallbladder carcinoma: A clinicopathological study and relationship with prognosis

Cited by 25 publications

References 0 publications

Expression of MUC1 in esophageal squamous-cell carcinoma and its relationship with prognosis of patients from Linzhou city, a high incidence area of northern China

Expression of MUC1 in esophageal squamous-cell carcinoma and its relationship with prognosis of patients from Linzhou city, a high incidence area of northern China

Expression of MUC1 (EMA) and E-cadherin in renal cell carcinoma: a systematic immunohistochemical analysis of 188 cases

Histological phenotype is correlated with the wall-invasion pattern of gallbladder adenocarcinoma

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