Motivated by the long-standing tension in the muon anomalous magnetic moment (AMM) and persistent observations of B-physics anomalies in R D ( * ) and R K ( * ) ratios, we construct a simple two-loop radiative neutrino mass model, and propose a combined explanations of all these apparently disjoint phenomena within this framework. Our proposed model consists of two scalar leptoquarks (LQs), a SU (2) L singletanomalies, respectively. The muon receives chirality-enhanced contribution towards its g − 2 due to the presence of S 1 LQ that accounts for the observed deviation from the Standard Model prediction. Furthermore, we introduce a SU (2) L singlet scalar diquark ω ∼ (6, 1, 2/3), which is necessary to break lepton number and generate neutrino mass radiatively with the aid of S 1 and S 3 LQs. We perform a detailed phenomenological analysis of this set-up and demonstrate its viability by providing benchmark points where a fit to the neutrino oscillation data together with proper explanations of the muon AMM puzzle and flavor anomalies are accomplished while simultaneously meeting all other flavor violation and collider bounds.