Mu opioid receptor expressing neurons in the rostral ventromedial medulla are the source of mechanical hypersensitivity induced by repeated restraint stress

Imbe, Hiroki; Ihara, Hayato

doi:10.1016/j.brainres.2023.148465

Cited by 1 publication

(1 citation statement)

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“…Psychological stress causes dysfunction of the descending pain controls [ 64 ]. Neural changes in the NRM and DH, key components of the descending pain controls, induce chronic pain [ 9 , 25 , 26 , 65 ]. In the absence of formalin injection, c-Fos and FosB expressions in the NRM and DH of FST mice were not affected ( Figure 7 and Figure 8 ), although other stress models increased these [ 27 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Preventive Roles of Rice-koji Extracts and Ergothioneine on Anxiety- and Pain-like Responses under Psychophysical Stress Conditions in Male Mice

Piriyaprasath,

Kakihara,

Kurahashi

et al. 2023

Nutrients

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This study determined the effect of daily administration of Rice-koji on anxiety and nociception in mice subjected to repeated forced swim stress (FST). In a parallel experiment, it was determined whether ergothioneine (EGT) contained in Rice-koji displayed similar effects. Anxiety and nociception were assessed behaviorally using multiple procedures. c-Fos and FosB immunoreactivities were quantified to assess the effect of both treatments on neural responses in the paraventricular nucleus of the hypothalamus (PVN), nucleus raphe magnus (NRM), and lumbar spinal dorsal horn (DH). FST increased anxiety- and pain-like behaviors in the hindpaw. Rice-koji or EGT significantly prevented these behaviors after FST. In the absence of formalin, both treatments prevented decreased FosB expressions in the PVN after FST, while no effect was seen in the NRM and DH. In the presence of formalin, both treatments prevented changes in c-Fos and FosB expressions in all areas in FST mice. Further, in vitro experiments using SH-SY5Y cells were conducted. Rice-koji and EGT did not affect cell viability but changed the level of brain-derived neurotrophic factor. In conclusion, Rice-koji could reduce anxiety and pain associated with psychophysical stress, possibly mediated by the modulatory effects of EGT on neural functions in the brain.

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