mTORC2 knockdown mediates lipid metabolism to alleviate hyperlipidemic pancreatitis through PPARα
Xiangyang Wang,
Yilei Liu,
Yaxiong Zhou
et al.
Abstract:Hyperlipidemic pancreatitis (HP) is an inflammatory injury of the pancreas triggered by elevated serum triglyceride (TG) levels. The mechanistic target of rapamycin (mTOR) signaling pathway plays a crucial role in regulating lipid homeostasis and inflammation. This study aimed to investigate whether the activity of mTOR complex 2 (mTORC2) affects the progression of HP and its underlying mechanisms. In vivo, a high‐fat diet and retrograde administration of sodium taurocholate were employed to establish the HP m… Show more
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