Abstract:25Although mTOR signaling is known as a broad regulator of cell growth and proliferation, in 26 neurons it regulates synaptic transmission, which is thought to be a major mechanism through which 27 altered mTOR signaling leads to neurological disease. Although previous studies have delineated 28 postsynaptic roles for mTOR, whether it regulates presynaptic function is largely unknown. Moreover, 29 the mTOR kinase operates in two complexes, mTORC1 and mTORC2, suggesting that mTOR's role in 30 synaptic transmiss… Show more
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