mTOR inhibitor rapamycin alone or combined with cisplatin inhibits growth of esophageal squamous cell carcinoma in nude mice

High expression of phosphorylated 4E-binding protein 1 is an adverse prognostic factor in esophageal squamous cell carcinoma

“…The mTOR inhibitor rapamycin and small interference RNA against mTOR were shown to inhibit the expression of mTOR, suppress the phosphorylation of its major downstream effectors S6K and 4E-BP1, and arrest the cells in the G0/G1 phase. In addition, an animal study confirmed that mTOR inhibitor rapamycin alone or combined with cisplatin can inhibit growth of esophageal SCC in nude mice [16].…”

Knockdown of the Bmi-1 oncogene inhibits cell proliferation and induces cell apoptosis and is involved in the decrease of Akt phosphorylation in the human breast carcinoma cell line MCF-7

“…Male athymic BALB/c nude mice (Vital River Animal Ltd., Beijing, China) at 4-5 weeks of age were used in the study. The conditions of animals-farming were prepared according to previous published method (15). MCF-7 cells were dissociated with trypsin-EDTA and suspended in PBS at a density of (1x10 7 cells/ml).…”

Comparison of the effect of p65 siRNA and curcumin in promoting apoptosis in esophageal squamous cell carcinoma cells and in nude mice

“…Only single-cell suspensions with 90% viability were used for injection. Cell resuspension (200 µl) (4x10 6 cells) was inoculated s.c. into the right flank of athymic mice (16).…”