mTOR hyperactivity and RICTOR amplification as targets for personalized treatments in malignancies
Dániel Sztankovics,
Dorottya Moldvai,
Gábor Petővári
et al.
Abstract:The increasing knowledge of molecular alterations in malignancies, including mutations and regulatory failures in the mTOR (mechanistic target of rapamycin) signaling pathway, highlights the importance of mTOR hyperactivity as a validated target in common and rare malignancies. This review summarises recent findings on the characterization and prognostic role of mTOR kinase complexes (mTORC1 and mTORC2) activity regarding differences in their function, structure, regulatory mechanisms, and inhibitor sensitivit… Show more
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