MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study

Hishida, Asahi; Okada, Rieko; Yin, Guang; Naito, Mariko; Wakai, Kenji; Hosono, Satoyo; Nakamura, Kazuyo; Turin, Tanvir Chowdhury; Suzuki, Sadao; Niimura, Hideshi; Mikami, Haruo; Otonari, Jun; Kuriyama, Nagato; Katsuura, Sakurako; Kubo, Michiaki; Tanaka, Hideo; Hamajima, Nobuyuki

doi:10.1007/s11255-013-0432-0

Cited by 10 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another large-scale cross-sectional study in Japan found no significant interaction between MTHFR C677T and blood folate concentration on CKD. [ 116 ] Further stratified analysis found that the risk of developing CKD was higher in subjects with the TT genotype and low blood folate concentration (OR = 2.07, 95% CI = 1.30–3.31). Regarding drug–gene interactions, many RCTs have showed significant interactions between MTHFR C677T and folate supplements.…”

Section: Discussionmentioning

confidence: 99%

Decisive evidence corroborates a null relationship between MTHFR C677T and chronic kidney disease

Chang

Chen²,

Hsiao

et al. 2020

Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Decisive evidence corroborates a null relationship between MTHFR C677T and chronic kidney disease

Chang

Chen²,

Hsiao

et al. 2020

Medicine

View full text Add to dashboard Cite

show abstract

“…Logistic regression analysis was performed to estimate age- and sex-adjusted ORs and 95% CIs for CKD by genotype. All other potential confounding variables, including BMI, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, glycated hemoglobin, total cholesterol, HDL cholesterol, triglycerides, uric acid, past history of cardiovascular or cerebrovascular diseases, use of anti-hypertensive, glucose-lowering, or lipid-lowering drugs, smoking status, and drinking habit were tested [ 39 ] to determine if they produced significant CIEs, as described previously [ 40 , 41 ].…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study

et al. 2014

Self Cite

View full text Add to dashboard Cite

BackgroundChronic kidney disease (CKD) is known to be one of the causes of cardiovascular disease and end-stage renal disease. Among the several treatable risk factors of CKD, that of dyslipidemia is relatively controversial. To clarify the association of polymorphisms in genes involved in lipid metabolism with the risk of CKD in the Japanese population, we used cross-sectional data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.MethodsA total of 3,268 men and women, aged 35–69 years, were selected from J-MICC Study participants for inclusion in this study. Twenty-eight candidate single nucleotide polymorphisms (SNPs) were selected in 17 genes associated with the risk of lipid metabolism disorders, and genotyping of the subjects was conducted using the multiplex PCR-based invader assay. The prevalence of CKD was determined for stages 3–5 (defined as estimated glomerular filtration rate <60 ml/min/1.73 m2).ResultsLogistic regression analysis revealed that SNPs APOA5 T − 1131C (rs662799), APOA5 T1259C (rs2266788), TOMM40 A/G (rs157580), and CETP TaqIB (rs708272) were significantly associated with CKD risk in those individuals genotyped, with age- and sex-adjusted odds ratios (ORs) per minor allele (and 95% confidence intervals (CIs)) of OR 1.22 (95% CI: 1.06–1.39), 1.19 (1.03–1.37), 1.27 (1.12–1.45), and 0.81 (0.71–0.92), respectively. Analysis of the gene–environment interaction revealed that body mass index (BMI) was a significant effect modifier for APOA5 T − 1131C (rs662799) and a marginally significant effect modifier for APOA5 T/C (rs2266788), with the interaction between BMI ≥30 and individuals with at least one minor allele of each genotype of OR 10.43 (95% CI: 1.29–84.19) and 3.36 (0.87–13.01), respectively.ConclusionsFour polymorphisms in APOA5, TOMM40, and CETP were shown to be significantly associated with CKD risk, and a significant interaction between the two APOA5 SNPs and BMI on CKD risk was also demonstrated. This suggests the future possibility of personalized risk estimation for this life-limiting disease.Electronic supplementary materialThe online version of this article (doi:10.1186/1476-511X-13-162) contains supplementary material, which is available to authorized users.

show abstract

“…Our results showed an association between the MTHFR variant and the resistance index to the erythropoietin. Different studies show that ESRD patients homozygous for the mutant allele rs1801133 have increased mortality risk 76 , and associations of the MTHFR gene with CKD progression have also been reported 77,78 .…”

Section: Scientific Reports |mentioning

confidence: 99%

Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population

Corredor

Filho

Rodríguez-Ribera

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Chronic kidney disease (CKD) patients have many affected physiological pathways. Variations in the genes regulating these pathways might affect the incidence and predisposition to this disease. A total of 722 Spanish adults, including 548 patients and 174 controls, were genotyped to better understand the effects of genetic risk loci on the susceptibility to CKD. We analyzed 38 single nucleotide polymorphisms (SNPs) in candidate genes associated with the inflammatory response (interleukins IL-1A, IL-4, IL-6, IL-10, TNF-α, ICAM-1), fibrogenesis (TGFB1), homocysteine synthesis (MTHFR), DNA repair (OGG1, MUTYH, XRCC1, ERCC2, ERCC4), renin-angiotensin-aldosterone system (CYP11B2, AGT), phase-II metabolism (GSTP1, GSTO1, GSTO2), antioxidant capacity (SOD1, SOD2, CAT, GPX1, GPX3, GPX4), and some other genes previously reported to be associated with CKD (GLO1, SLC7A9, SHROOM3, UMOD, VEGFA, MGP, KL). The results showed associations of GPX1, GSTO1, GSTO2, UMOD, and MGP with CKD. Additionally, associations with CKD related pathologies, such as hypertension (GPX4, CYP11B2, ERCC4), cardiovascular disease, diabetes and cancer predisposition (ERCC2) were also observed. Different genes showed association with biochemical parameters characteristic for CKD, such as creatinine (GPX1, GSTO1, GSTO2, KL, MGP), glomerular filtration rate (GPX1, GSTO1, KL, ICAM-1, MGP), hemoglobin (ERCC2, SHROOM3), resistance index erythropoietin (SOD2, VEGFA, MTHFR, KL), albumin (SOD1, GSTO2, ERCC2, SOD2), phosphorus (IL-4, ERCC4 SOD1, GPX4, GPX1), parathyroid hormone (IL-1A, IL-6, SHROOM3, UMOD, ICAM-1), C-reactive protein (SOD2, TGFB1,GSTP1, XRCC1), and ferritin (SOD2, GSTP1, SLC7A9, GPX4). To our knowledge, this is the second comprehensive study carried out in Spanish patients linking genetic polymorphisms and CKD.Chronic kidney disease (CKD) is becoming a major public health problem worldwide. CKD is defined as a progressive loss of renal function, measured by a decline in glomerular filtration rate (GFR < 60 mL/min/1.73 m 2 ) 1 , which is typically associated with irreversible pathological changes within the kidney. This pathology has a complicated interrelationship with other diseases 2,3 . Diabetes (DM) and hypertension (HT) are the primary risk factors for CKD 4 , and CKD is also associated with cardiovascular morbidity and mortality 5,6 , even in early stages and in young patients 7 .CKD patients are also characterized by a high genomic instability [8][9][10][11] . This instability could be translated to high levels of genetic damage measured by the incidence of chromosomal damage (micronuclei) when their cells are challenged with ionizing radiation 12 and could be either the cause or the consequence of renal pathologies. In addition, it has been observed that CKD patients repair less efficiently DNA damage 13 .CKD patients present increased levels of C-reactive protein (CRP), which is indicative of an inflammatory status 12,14,15 . Oxidative stress is also a characteristic usually shown by CKD patients [16][17][18][19] . Variants in genes reg...

show abstract

MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study

Cited by 10 publications

References 23 publications

Decisive evidence corroborates a null relationship between MTHFR C677T and chronic kidney disease

Decisive evidence corroborates a null relationship between MTHFR C677T and chronic kidney disease

Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study

Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population

Contact Info

Product

Resources

About