MTHFR Gene Polymorphism In Patients Of Myocardial Infarction

Abstract

:Homocysteine is an emerging new risk factor for cardiovascular disease. A common polymorphism in the gene coding for the 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with a decreased activity of the enzyme due to thermolability. There is an accumulating evidence that adequate intake of folate may protect the risk of developing the athero-thrombotic disease and its complications. Hyperhomocysteinemia (HCA)either due to mutation of MTHFR gene or deficiency of vitamin B12 and folic acid, has been reported as a risk factor for coronary artery disease (CAD).the present study was aimed to determine plasma homocysteine (hcy) levels and to evaluate MTHFR C677T gene polymorphism as risk factors for CAD in younger Indians. the effect of vitamin B12 and folic acid supplements on the raised plasma hcy levels in patients with CAD was also assessed. In our results, 6 cases are effected with a mutation in MTHFR gene. among them 4 individuals may face the future threat of myocardial infarction remaining 2 individuals are mutated and risk factors are similar to that of myocardial infarction.

Folate Metabolism. Polymorphisms of Methylentetrahydrofolate Reductase. Concurrent Factor in Pathogenic Effects

“…Whether due to folate or vitamin B12 deficiency or MTHFR polymorphism, increases in homocysteine can be observed, a known factor that increases the risk of cardiovascular disease. On the risk of cardiovascular disease associated with MTHFR polymorphisms, with biotypes C677T, T677T and A1298C, observations are still insufficient, but they seem to be associated with increases in homocysteine [63][64][65].…”