Abstract:Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme involved in homocysteine/methionone metabolism. It catalyzes the conversion of 5,10methlenetetrahydrofolate in to 5methyltetrahydrofolate. A number of studies have examined the association of MTHFR A1298C polymorphism as risk factor for Alzheimer's disease (AD), but the results were contradictory. To clarify the influence of MTHFR A1298C polymorphism on Alzheimer's disease (AD), a meta-analysis of ten case-control studies was carried out. Four ele… Show more
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