MTHFR C677T polymorphism is associated with follicle-stimulating hormone levels and controlled ovarian hyperstimulation response: a retrospective study from the clinical database

Zeng, Shuangshuang; Wang, Xiang; Wang, Yonggang; Xu, Zhijie; Zhang, Jingping; Liu, Wanli; Qian, Long; Chen, Xi; Wei, Jie; Yan, Yuanliang; Gong, Zhicheng

doi:10.1016/j.fertnstert.2019.01.016

Cited by 6 publications

(3 citation statements)

References 45 publications

(46 reference statements)

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“…In the present study, women with few numbers of oocytes following ovarian stimulation (POR) had a higher distribution of minor C-allele in rs1801131 and T-allele in rs1801133 polymorphisms. In agreement with our findings, several observations found a higher prevalence of the MTHFR rs1801131 alleles in patients with diminished response to ovarian stimulation [12,33]. These data, however, was not replicated in another study in COS outcomes [1].…”

Section: Discussionsupporting

confidence: 85%

“…However, in contrast to these polymorphisms, no association has so far been reported between anti-mullerian hormone type II receptor (AMHR2) SNPs and low or high response in controlled ovarian hyperstimulation [11]. Also, variations in methylenetetrahydrofolate reductase (MTHFR) are associated with follicle-stimulating hormone levels as well as diminished ovarian response to FSH stimulation and failing cycles of IVF in COS [12][13][14][15]. A link has also been shown between estrogen agonist and levels of endothelial plasminogen activator inhibitor (SERPINE1) [16].…”

Section: Introductionmentioning

confidence: 99%

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Involvement of single nucleotide polymorphisms in ovarian poor response

Ghaderian

Akbarzadeh

Salehpour

2021

J Assist Reprod Genet

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Purpose Unpredictability in acquiring an adequate number of high-quality oocytes following ovarian stimulation is one of the major complications in controlled ovarian hyperstimulation (COH). Genetic predispositions of variations could alter the immunological profiles and consequently be implicated in the variability of ovarian response to the stimulation. Design Uncovering the influence of variations in AMHR2, LHCGR, MTHFR, PGR, and SERPINE1 genes with ovarian response to gonadotrophin stimulation in COH of infertile women. Methods Blood samples of the women with a good ovarian response (GOR) or with a poor ovarian response (POR) were collected. Genomic DNA was extracted, and gene variations were genotyped by TaqMan SNP Genotyping Assays using primer-probe sets or real-time PCR Kit. Results Except for PGR (rs10895068), allele distributions demonstrate that the majority of POR patients carried minor alleles of AMHR2 (rs2002555, G-allele), LHCGR (rs2293275, G-allele), MTHFR (rs1801131, C-allele, and rs1801133, T-allele), and SERPINE1 (rs1799889, 4G allele) genes compared to the GOR. Similarly, genotypes with a minor allele in AMHR2, LHCGR, MTHFR, and SERPINE1 genes had a higher prevalence among POR patients with the polymorphic genotypes. However, further genotype stratification indicated that the minor alleles of these genes are not associated with poor response. Multivariate logistic analysis of clinical−demographic factors and polymorphic genotypes demonstrated a correlation between FSH levels and polymorphic genotypes of SERPINE1 in poor response status. Conclusions Despite a higher prevalence of AMHR2, LHCGR, MTHFR, and SERPINE1 variations in the patients with poor ovarian response, it seems that these variations are not associated with the ovarian response.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Involvement of single nucleotide polymorphisms in ovarian poor response

Ghaderian

Akbarzadeh

Salehpour

2021

J Assist Reprod Genet

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“…According to previous studies, MTHFR genotype mutations are associated with miscarriage and RPL [16,[28][29][30]. Moreover, MTHFR polymorphisms are also involved in poor ovarian stimulation responses in ART treatment [31], and folic acid supplementation improves ovulation disorders [32]. However, there were no significant differences in the miscarriage rate, length of menstruation cycle and rate of ovulation disorders in the three groups in our study.…”

Section: Discussionmentioning

confidence: 38%

Effects of Periconceptional Multivitamin Supplementation on Folate and Homocysteine Levels Depending on Genetic Variants of Methyltetrahydrofolate Reductase in Infertile Japanese Women

Kuroda

Horikawa²,

Gekka³

et al. 2021

Nutrients

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Methylenetetrahydrofolate reductase (MTHFR) has various polymorphisms, and the effects of periconceptional folic acid supplementation for decreasing neural tube defects (NTDs) risk differ depending on the genotypes. This study analyzed the effectiveness of multivitamin supplementation on folate insufficiency and hyperhomocysteinemia, depending on MTHFR polymorphisms. Of 205 women, 72 (35.1%), 100 (48.8%) and 33 (16.1%) had MTHFR CC, CT and TT, respectively. Serum folate and homocysteine levels in women with homozygous mutant TT were significantly lower and higher, respectively, than those in women with CC and CT. In 54 women (26.3% of all women) with a risk of NTDs, multivitamin supplementation containing folic acid and vitamin D for one month increased folate level (5.8 ± 0.9 to 19.2 ± 4.0 ng/mL, p < 0.0001) and decreased the homocysteine level (8.2 ± 3.1 to 5.8 ± 0.8 nmol/mL, p < 0.0001) to minimize the risk of NTDs in all women, regardless of MTHFR genotype. Regardless of MTHFR genotype, multivitamin supplements could control folate and homocysteine levels. Tests for folate and homocysteine levels and optimal multivitamin supplementation in women with risk of NTDs one month or more before pregnancy should be recommended to women who are planning a pregnancy.

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