MTHFR C677T Polymorphism and its Homocysteine-Driven Effect on Blood Pressure

Saraswathy, Kallur Nava; Garg, Priyanka Rani; Kabita, Salam; Joshi, Sachindra; Huidrom, Suraj Singh; Ghosh, Pradeep

doi:10.1111/ijs.12276

Cited by 5 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with our results, the studies by Heifetz and Birk had shown that tHcy may contribute to the effect of MTHFR C677T genotypes on blood pressure levels. 24 More importantly, Saraswathy et al 25 also suggested that MTHFR 677TT genotype and elevated tHcy levels (even in the upper limits of the normal range of 5–15 μmol/L) are significantly associated with hypertension regardless of age and gender in a Northeastern population with East Asian ancestry.…”

Section: Discussionmentioning

confidence: 99%

Association of total homocysteine with blood pressure in a general population of Chinese adults: a cross-sectional study in Jiangsu province, China

Zhang

Ban

et al. 2018

BMJ Open

View full text Add to dashboard Cite

ObjectivesWe aimed to evaluate the relation of total homocysteine (tHcy) concentrations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, and examine the possible modifiers in the association among a general population of Chinese adults.DesignA cross-sectional study.SettingThe study was conducted within 21 communities in Lianyungang of Jiangsu province, China.ParticipantsA total of 26 648 participants aged ≥35 years and with no antihypertensive drug use were included in the final analysis.ResultsOverall, there was a positive association between tHcy concentrations and SBP (per 5 μmol/L tHcy increase: adjusted β=0.45 mm Hg; 95% CI 0.29 to 0.61) or DBP levels (per 5 μmol/L tHcy increase: adjusted β=0.47 mm Hg; 95% CI 0.35 to 0.59). Compared with participants with tHcy <10 μmol/L, significantly higher SBP levels were found in those with tHcy concentrations of 10 to <15 (adjusted β=0.80 mm Hg; 95% CI 0.32 to 1.28) and ≥15 µmol/L (adjusted β=1.79 mm Hg; 95% CI 1.20 to 2.37; p for trend <0.001). Consistently, significantly higher DBP levels were found in participants with tHcy concentrations of 10 to <15 (adjusted β=0.86 mm Hg; 95% CI 0.49 to 1.22) and ≥15 µmol/L (adjusted β=2.01 mm Hg; 95% CI 1.57 to 2.46; p for trend <0.001), respectively as compared with those with <10 μmol/L. Furthermore, a stronger association between tHcy and SBP (p for interaction=0.009) or DBP (p for interaction=0.067) was found in current alcohol drinkers.ConclusionSerum tHcy concentrations were positively associated with both SBP and DBP levels in a general Chinese adult population. The association was stronger in current alcohol drinkers.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of total homocysteine with blood pressure in a general population of Chinese adults: a cross-sectional study in Jiangsu province, China

Zhang

Ban

et al. 2018

BMJ Open

View full text Add to dashboard Cite

show abstract

“…We examined the effect of high levels of non-HDL-C on blood pressure. Characteristics of the individuals have been published previously (4) in this journal. Hypertensive individuals were found to have significantly higher mean levels of both LDL-C and non-HDL-C than the normotensives.…”

mentioning

confidence: 99%

“…Non-HDL-C levels equal to or above 130 mg/dl are considered high (1). Therefore, subjects were divided into four categories, viz, (1) those having LDL-C < 100 mg/dl and non-HDL-C< 130 mg/dl (considered as reference group), (2) those having LDL-C < 100 mg/dl and non-HDL-C ⩾ 130 mg/dl, (3) those having LDL-C ⩾ 100 mg/dl and non-HDL-C < 130 mg/dl, and (4) those having LDL-C ⩾ 100 mg/dl and non-HDL-C ⩾ 130 mg/dl. Proportion of hypertensive and normotensive individuals in these four categories was calculated and associated risk for hypertension was estimated.…”

mentioning

confidence: 99%