MTHFR C677t and MTR A2756g Polymorphisms and the Homocysteine Lowering Efficacy of Different Doses of Folic Acid in Hypertensive Chinese Adults

Qin, Xianhui; Li, Jianping; Chen, Yimin; Liu, Zeyuan; Zhao, Zhigang; Ge, Junbo; Guan, Deming; Ji, Hu; Wang, Yanni; Zhang, Fumin; Xu, Xin; Wang, Xiaobin; Xu, Xiping; Huo, Yong

doi:10.1136/heartjnl-2012-302920c.8

Cited by 19 publications

(24 citation statements)

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“…Methylenetetrahydrofolate reductase (MTHFR) is the main regulatory enzyme for homocysteine (Hcy) metabolism . MTHFR catalyses reduction of 5,10‐ methylenetetrahydrofolate to 5‐methyltetrahydrofolate.…”

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confidence: 99%

Genetic polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and risk of vitiligo in Han Chinese populations: a genotype-phenotype correlation study

et al. 2014

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SummaryBackground Recent evidence has revealed an elevation of total homocysteine (tHcy) in patients with vitiligo. Methylenetetrahydrofolate reductase (MTHFR) is one of the main enzymes regulating homocysteine (Hcy) metabolism. Thus, polymorphisms of MTHFR could potentially contribute to the development of vitiligo by affecting MTHFR activity and tHcy levels. Objectives To evaluate the potential association between MTHFR polymorphisms and vitiligo susceptibility. Methods In total, 1000 patients with vitiligo and 1000 age-and sex-matched controls were enrolled in this hospital-based case-control study. Two single-nucleotide polymorphisms of the MTHFR gene (rs1801133 C>T and rs1801131 A>C) were selected and genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific PCR, respectively. The MTHFR activity concentration and tHcy level in serum were measured by enzyme-linked immunosorbent assay. Results We found that allele T of rs1801133 in the MTHFR gene was associated with a significantly reduced risk of vitiligo (adjusted odds ratio 0Á58, 95% confidence interval 0Á43-0Á76, P < 0Á001). In addition, the patients with vitiligo had a lower activity concentration of MTHFR and higher level of tHcy than the controls. Correlation between these markers and the risk of vitiligo was also observed. Furthermore, the individuals with a no-risk genotype (CT + TT) of rs1801133 and higher activity concentration of MTHFR or lower level of tHcy had a significantly decreased risk of vitiligo. Conclusions Our data suggest that MTHFR gene polymorphisms may play a vital role in genetic susceptibility to vitiligo.

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confidence: 99%

Genetic polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and risk of vitiligo in Han Chinese populations: a genotype-phenotype correlation study

et al. 2014

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“…Such a population provides a unique opportunity to observe the true association between the polymorphisms and the key enzymes in folate/Hcy metabolism. Although our previous studies on Chinese cohorts found that the MTHFR gene C677T polymorphism was a major determinant for both Hcy and folate levels, [45,46] the current meta-analysis suggests that neither the MTHFR A1298C polymorphism nor the MTRR A66G polymorphism affects plasma Hcy levels in the Chinese population. Hcy has been implicated in the pathogenesis of cardiovascular diseases, cancer, and birth defects.…”

Section: Discussionmentioning

confidence: 88%

Effect of MTHFR A1298C and MTRR A66G genetic mutations on homocysteine levels in the Chinese population: a systematic review and meta-analysis

Wang

Ouyang

et al. 2017

Journal of Translational Internal Medicine

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Background and Objectives: The Chinese population typically has inadequate folate intake and no mandatory folic acid fortification. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the two key regulatory enzymes in the folate/ homocysteine (Hcy) metabolism. Hcy has been implicated in the pathogenesis of cardiovascular disease. We conducted a meta-analysis to assess whether the MTHFR gene A1298C and the MTRR gene A66G polymorphisms affect Hcy levels in the Chinese population. Methods: This analysis included 13 studies with Hcy levels reported as one of the study measurements. Summary estimates of weighted mean differences and 95% confidence intervals (CIs) were obtained using random-effect models. Results: Overall, there were no significant differences in Hcy concentrations between participants with the MTHFR 1298 CC (12 trials, n = 129), AA (n = 2166; β, −0.51 μmol/L; 95%CI: −2.14, 1.11; P = 0.53), or AC genotype (n = 958; β, 0.55 μmol/L; 95%CI: −0.72, 1.82; P = 0.40). Consistently, compared to those with the MTRR 66 GG genotype (6 trials, n = 156), similar Hcy concentrations were found in participants with the AA (n = 832; β, −0.43 μmol/L; 95%CI: −1.04, 0.17; P = 0.16) or AG (n =743; β, −0.57 μmol/L; 95%CI: −1.46, 0.31; P = 0.21) genotype. Similar results were observed for the dominant and recessive models. Conclusions: Neither the MTHFR A1298C polymorphism nor the MTRR A66G polymorphism affects Hcy levels in the Chinese population.

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“…The details regarding "Participants", "Data collection procedures", and "Laboratory methods" have been previously described (Qin et al, 2012a;2012b;2012c). Briefly, a total of 378 hypertensive patients aged 18-75 years old, with seated systolic blood pressure (SBP) between 140 and 180 mmHg and/or seated diastolic blood pressure (DBP) between 90 and 110 mmHg, were recruited from one hospital in each of five cities (Harbin, Shanghai, Beijing, Xi'an, and Nanjing) located in different regions, from September to December, 2005.…”

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confidence: 99%

Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases

Zhang

Chen

et al. 2013

J. Zhejiang Univ. Sci. B

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Abstract:Objective: High body mass index (BMI) is considered as the most important risk factor for elevated serum alanine aminotransferase (ALT) concentration. This study examined an array of factors, including waist circumference (WC) and folate deficiency, which may mediate the association of BMI with serum ALT concentration in Chinese hypertensive adults without known hepatic diseases. Methods: A multicenter, cross-sectional study was carried out. A total of 378 patients with mild or moderate hypertension and without known hepatic diseases were recruited from five hospitals in Harbin, Shanghai, Beijing, Xi'an, and Nanjing. Results: Of the 360 hypertensive patients with complete data in our final analysis, 13.6% had high ALT concentrations (>40 IU/L). Factors including BMI, WC, triglyceride level, and folate concentration were associated with ALT concentration in univariate analysis. Consistently higher prevalence rates of elevated ALT were observed in subjects with lower folate concentrations (≥12 vs. <12 nmol/L, 9.9% vs. 17.8%, P=0.03), with higher BMI (≥28 vs. <28 kg/m 2 , 21.5% vs. 11.4%, P=0.02) or higher WC (≥90 vs. <90 cm, 18.5% vs. 10.0%, P=0.02). However, in multivariate analysis, the association between BMI and ALT concentration disappeared (P=0.802 in males and 0.369 in females), while WC in females (P<0.001) and folate concentration (P=0.036 in males and 0.044 in females) remained as significant predictors for ALT concentration. Conclusions: This multicenter study demonstrated that WC and low folate concentration were important factors underlying the association between BMI and ALT concentrations in Chinese hypertensive adults without known hepatic diseases.

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MTHFR C677t and MTR A2756g Polymorphisms and the Homocysteine Lowering Efficacy of Different Doses of Folic Acid in Hypertensive Chinese Adults

Cited by 19 publications

References 0 publications

Genetic polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and risk of vitiligo in Han Chinese populations: a genotype-phenotype correlation study

Genetic polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and risk of vitiligo in Han Chinese populations: a genotype-phenotype correlation study

Effect of MTHFR A1298C and MTRR A66G genetic mutations on homocysteine levels in the Chinese population: a systematic review and meta-analysis

Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases

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