MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients

Maintenance of activities of daily living despite risk from genetic polymorphism in hemodialysis patients under nutritional management who survived an average of 30 years

“…Many studies reported that MTHFR C677T polymorphism is a risk factor for nephropathy, and a significantly high frequency of the TT genotype in nephropathy patients was also detected in a meta-analysis conducted by Yang et al [25]. Similar results were obtained in studies of Asians reported by Sun et al [26] and Mtiraoui et al [27]. In studies of Japanese hemodialysis patients, Kimura et al [22] investigated the association between MTHFR C677T and hyperhomocysteinemia, and Morimoto et al [11] investigated MTHFR C677T, hyperhomocysteinemia, and risk of cardiovascular disease, but they did not investigate whether the polymorphism is a risk factor for nephropathy.…”

“…In studies of Japanese hemodialysis patients, Kimura et al [22] investigated the association between MTHFR C677T and hyperhomocysteinemia, and Morimoto et al [11] investigated MTHFR C677T, hyperhomocysteinemia, and risk of cardiovascular disease, but they did not investigate whether the polymorphism is a risk factor for nephropathy. However, they investigated the genotype frequency of MTHFR C677T in hemodialysis patients, and the frequency of the TT genotype was similar to those reported by Sun et al [26] and Mtiraoui et al [27]. The TT genotype have been reported as a risk factor for cardiovascular disease by Morimoto et al [11], and for death in end-stage renal failure patients by Jamison et al [28], which cannot be explained by the results of our study.…”

Polymorphisms (C677T and A1298C) of MTHFR Gene in Sporadic Gastrointestinal Cancers in Tunisian Population: Interaction with Dairy Products, Treatment and Prognostic Factors

“…The higher prevalence is reported in Italian and French populations, in our study we have found a high prevalence of TT genotype (10.3%) similar to that described in Kashmiri population [25]. In this study the frequency in control groups of MTHFR TT is 4.4% which is slightly lower than in other studies on the Tunisian population [26]. Many studies suggested that MTHFR polymorphism is associated with CRC and gastric cancer.…”

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to diabetic nephropathy in Chinese type 2 diabetic patients: a meta-analysis

“…37,38 Hyperhomocysteinemia has been implicated as a risk factor not only for arterial or venous thrombosis but also for nephropathy in type 2 diabetes patients. 11,39 In addition, some studies indicated that homocysteine could increase the expression of vascular endothelial growth factor (VEGF). 40,41 While, VEGF is a pro-angiogenic factor which plays a role in the pathogenesis of DN.…”