mtDNA Maintenance and Alterations in the Pathogenesis of Neurodegenerative
Diseases

Shang, Dehao; Huang, Ming-Jer; Wang, Biyao; Xu, Yan; Wu, Zhou; Zhang, Xinwen

doi:10.2174/1570159x20666220810114644

Cited by 6 publications

(3 citation statements)

References 237 publications

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“…A12308G was associated with psychosis in both disorders [ 124 ]. Several point mtDNA mutation deletions and methylation, as well as changes in mtDNA copy numbers, have been associated with neurodegenerative disorders including PD and AD, amyotrophic lateral sclerosis, and Huntington’s disease (for a review see [ 125 ]). In monozygotic twins discordant for schizophrenia, a discordance in mtDNA copy number estimates was observed suggesting post-zygotic mtDNA changes that may contribute to the discordance in the disease between monozygotic twins [ 126 ].…”

Section: Mitochondria and Cns Diseasesmentioning

confidence: 99%

Mitochondria in the Central Nervous System in Health and Disease: The Puzzle of the Therapeutic Potential of Mitochondrial Transplantation

Tripathi,

Ben-Shachar

2024

Cells

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Mitochondria, the energy suppliers of the cells, play a central role in a variety of cellular processes essential for survival or leading to cell death. Consequently, mitochondrial dysfunction is implicated in numerous general and CNS disorders. The clinical manifestations of mitochondrial dysfunction include metabolic disorders, dysfunction of the immune system, tumorigenesis, and neuronal and behavioral abnormalities. In this review, we focus on the mitochondrial role in the CNS, which has unique characteristics and is therefore highly dependent on the mitochondria. First, we review the role of mitochondria in neuronal development, synaptogenesis, plasticity, and behavior as well as their adaptation to the intricate connections between the different cell types in the brain. Then, we review the sparse knowledge of the mechanisms of exogenous mitochondrial uptake and describe attempts to determine their half-life and transplantation long-term effects on neuronal sprouting, cellular proteome, and behavior. We further discuss the potential of mitochondrial transplantation to serve as a tool to study the causal link between mitochondria and neuronal activity and behavior. Next, we describe mitochondrial transplantation’s therapeutic potential in various CNS disorders. Finally, we discuss the basic and reverse—translation challenges of this approach that currently hinder the clinical use of mitochondrial transplantation.

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Section: Mitochondria and Cns Diseasesmentioning

confidence: 99%

Mitochondria in the Central Nervous System in Health and Disease: The Puzzle of the Therapeutic Potential of Mitochondrial Transplantation

Tripathi,

Ben-Shachar

2024

Cells

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“…In this way, defective mitophagy caused by mtDNA mutations may contribute to the development of chronic diseases, including cancers, neurodegenerative diseases, and metabolic disorders. [144][145][146] Therefore, it is important to understand the relationship between mutations in mtDNA, mitochondrial dysfunction, and mitophagy defects. Mitochondrial DNA mutations were found to be associated with atherosclerosis.…”

Section: Defective Mitophagy and Mtdna Mutationsmentioning

confidence: 99%

Role of Mitochondria in the Chronification of Inflammation: Focus on Dysfunctional Mitophagy and Mitochondrial DNA Mutations

Orekhov,

Summerhill,

Khotina

et al. 2023

Gene Expr

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Inflammation is a natural reaction of the innate immune system that evolved primarily to protect the human body from invading pathogens and to heal injuries. There are two different types of inflammation, acute and chronic inflammation, differing in duration, underlying causes, and characteristics. The acute-to-chronic transition can be determined by several pathomechanisms, including dysregulation of immune response and failure to eliminate the underlying cause. Moreover, epigenetic changes that refer to modifications in gene expression that are heritable but do not involve changes to the underlying DNA sequence can also contribute to prolonged inflammation. Emerging evidence suggests that dysfunctional mitochondria can promote the development of chronic inflammation. In this respect, the mechanisms triggering defective mitophagy, a selective form of autophagy that exterminates dysfunctional mitochondria to maintain cellular homeostasis, attracted special attention. The hypothesis on the pivotal role of mutations in mitochondrial DNA causing defective mitophagy stimulated the area of the research that applies editing of the mitochondrial genome. The mitoCAS9 vector and two single guide RNAs to the G15059A mutation were used to eliminate the mutation from the macrophage-like cells. The normal activity of the initially defective mitophagy was restored in intact macrophage-like cells, confirming the causal role of the G15059A mutation in the disruption of the mitophagy process. The unraveling of the underlying mechanisms of chronic inflammation will help to develop targeted therapeutic approaches aimed at restoring mitochondrial health and alleviating chronic inflammation that can be used for the treatment of a wide range of chronic inflammatory diseases.

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“…In 2022, about 1.04 × 10 6 pines were destroyed by PWD in China. To date, in-situ incineration of IPW has the potential to control the spread of PWD (Shang 2023). However, it increases the risk of forest fires and reduces carbon storage in forests (Wen et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Conversion of infected pine wood into energy charcoal material based on a transportable carbonization system

Ni,

Gao,

Ren

et al. 2024

Biochar

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To prevent the spread of pine wilt disease (PWD), a transportable carbonization equipment was designed for in-situ treatment of infected pine wood (IPW). The equipment killed all pine wood nematodes (PWNs) in IPW when carbonization temperature was up to 200 °C. The optimal laboratory process of infected pine wood charcoal (IPWC) was carbonization temperature of 500 °C, heating rate of 3 °C min−1 and holding time of 0 min. Based on the optimal laboratory process, the transportable carbonization equipment produced IPWC with a fixed carbon content of 79.82%, and ash content of 1.14% and a moisture content of 7.83%, which meets the requirements of EN 1860-2:2005(E) standard. The economic efficiency of incineration (T1 mode), crushing (T2 mode), and transportable carbonization (T3 mode) was evaluated. For each ton of IPW treatment, the profit generated was −75.48 USD in T1 mode, 26.28 USD in T2 mode, and 51.91 USD in T3 mode. T3 mode had the highest economic efficiency. These findings will be helpful to provide guidance for the control of PWD and value-added utilization of IPW. Graphical Abstract

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mtDNA Maintenance and Alterations in the Pathogenesis of Neurodegenerative Diseases

Cited by 6 publications

References 237 publications

Mitochondria in the Central Nervous System in Health and Disease: The Puzzle of the Therapeutic Potential of Mitochondrial Transplantation

Mitochondria in the Central Nervous System in Health and Disease: The Puzzle of the Therapeutic Potential of Mitochondrial Transplantation

Role of Mitochondria in the Chronification of Inflammation: Focus on Dysfunctional Mitophagy and Mitochondrial DNA Mutations

Conversion of infected pine wood into energy charcoal material based on a transportable carbonization system

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