MTA HP Repair stimulates in vitro an homogeneous calcium phosphate phase coating deposition

Jiménez-Sánchez, María C; Segura-Egea, Juan José; Díaz‐Cuenca, Aránzazu

doi:10.4317/jced.55661

Cited by 12 publications

(23 citation statements)

References 21 publications

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“…MTA Repair HP dental material is endodontic cement, which shows both a rapid setting rate of 12 min (initial setting time) [21], and a quick and effective bioactive response in vitro in terms of surface coating of calcium phosphate [19]. In this work, a detailed look at the material microstructure highlights particular characteristics to understand these interesting properties.…”

Section: Discussionmentioning

confidence: 97%

“…The new MTA Repair HP material stands out as a singular BEC material because of both, the short setting time and the quick and effective bioactive response in vitro [19]. MTA Repair HP has shown cytocompatibility and the ability to promote an adequate biological response in human dental pulp stem cells (hDPSCs) in terms of cell proliferation, morphology, migration, and attachment [20].…”

Section: Introductionmentioning

confidence: 99%

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A Microstructure Insight of MTA Repair HP of Rapid Setting Capacity and Bioactive Response

2020

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Mineral trioxide aggregate (MTA) is considered a bioactive endodontic material, which promotes natural mineralization at the material-tooth tissue interface. MTA Repair HP stands out because of the short setting time and the quick and effective bioactive response in vitro. The bioactivity, depens on material composition and microstructure. This work is devoted to analyze MTA Repair HP microstructural features, of both the powder precursor and set material, to get insights into the material physicochemical parameters—functionality performance relationships. Transmission electron microscopy (TEM), and field emission gun scanning electron microscopy (FEG-SEM) coupled with energy-dispersive X-ray (EDX) analyses were performed. X-ray diffraction (XRD) measurements were carried out at different times to investigate setting process. Bioactivity evaluation in vitro was carried out by soaking the processed cement disk in simulated body fluid (SBF). The presented results point out those MTA Repair HP precursor material characteristics of tricalcium silicate particles of nanometric size and high aspect ratio, which provide an elevated surface area and maximized components dispersion of calcium silicate and very reactive calcium aluminate. The MTA Repair HP precursor powder nanostructure and formulation, allows a hydration process comprising silicate hydrate structures, which are very effective to achieve both fast setting and efficient bioactive response.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

A Microstructure Insight of MTA Repair HP of Rapid Setting Capacity and Bioactive Response

2020

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“…Esses cimentos possuem capacidade de lixiviar íons e produzir efeitos biológicos estimulando processos remineralizadores e regeneradores [6][7][8] , sendo também considerados cimentos endodônticos bioativos 7,8 .…”

Section: Introductionunclassified

“…Além disso, os cimentos endodônticos biocerâmicos apresentam ainda radiopacificadores compostos de bismuto, óxidos de zircônia, tântalo ou tungstênio, dependendo da composição do produto disponível no mercado 7,8 .…”

Section: Introductionunclassified

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Cimentos biocerâmicos reparadores fabricados e/ou disponíveis no Brasil: uma revisão de literatura e análise bibliométrica sobre suas propriedades biológicas

Júnior¹,

Torres²,

Missias³

et al. 2021

Arch Health Invest

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O agregado trióxido mineral (MTA) é um material hidráulico bioativo considerado padrão-ouro para vários procedimentos clínicos em Endodontia. Entretanto, alguns componentes de sua formulação original oferecem desvantagens. Sendo assim, novos cimentos hidráulicos indicados para finalidades reparadoras ou seladoras têm surgido no mercado visando contornar essas características desfavoráveis presentes nos materiais baseados na formulação original do MTA. Dentro desse contexto, o presente trabalho consiste em uma revisão de literatura e análise bibliométrica acerca dos cimentos biocerâmicos reparadores fabricados no Brasil, com ênfase nas evidências disponíveis acerca dos parâmetros biológicos desses cimentos. Além disso, também são apresentados alguns aspectos conceituais e gerais acerca desses produtos. Assim, a amostra de estudos incluídos na análise bibliométrica e na revisão de literatura correspondeu a um total de quatro artigos, os quais abrangiam investigações através de metodologias in vitro de avaliação de citotoxicidade e da morfologia e adesão celular sobre substratos confeccionados com os materiais testados, além de análises in vivo da biocompatibilidade tecidual. Os dados dos artigos avaliados no presente estudo evidenciaram resultados promissores em relação às propriedades biológicas de alguns dos cimentos avaliados (MTA HP Repair® e Bio-C Repair®). Entretanto, para um desses cimentos (PBS HD® Cimmo) sugere-se a realização de estudos adicionais voltadas para a investigação de suas propriedades biológicas.

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In vivo apatite-forming ability of second-generation hydraulic calcium silicate cements in rat subcutaneous tissue

Edanami

Takenaka

Belal

et al. 2022

Preprint

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Objectives The objective of this study was to evaluate the in vivo apatite-forming ability of 17 second-generation hydraulic calcium silicate cements (HCSCs) with the first-generation HCSC, white ProRoot MTA (PR). Materials and Methods Seventeen second-generation HCSCs and PR were implanted in rat subcutaneous tissue for 28 days. After inplantation, Raman spectra were taken from the surface of the HCSC implants and blindly evaluated for the presence or absence of a band at 960 cm− 1 indicating apatite. Apatite formation was also assessed with surface characterization and elemental mapping. Results The Raman band for apatite was detected on only seven second-generation HCSCs and PR. These seven HCSCs exhibited apatite-like calcium- and phosphorus-rich spherical precipitates on their surface. Three types of HCSCs had a Raman band at 962 cm− 1 that may have obscured the Raman band for apatite at 960 cm− 1; however, elemental mapping demonstrated the absence of calcium-phosphorus-rich apatite-layer-like regions on these HCSCs. Conclusions Only 7 of the 17 second-generation HCSCs and PR produced apatite in vivo within 28 days. Clinical Relevance: The 10 types of second-generation HCSCs that did not exhibit apatite formation may not be suitable substitutes for PR due to their weak in vivo apatite-forming ability.

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MTA HP Repair stimulates in vitro an homogeneous calcium phosphate phase coating deposition

Cited by 12 publications

References 21 publications

A Microstructure Insight of MTA Repair HP of Rapid Setting Capacity and Bioactive Response

A Microstructure Insight of MTA Repair HP of Rapid Setting Capacity and Bioactive Response

Cimentos biocerâmicos reparadores fabricados e/ou disponíveis no Brasil: uma revisão de literatura e análise bibliométrica sobre suas propriedades biológicas

In vivo apatite-forming ability of second-generation hydraulic calcium silicate cements in rat subcutaneous tissue

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