MSI-DTI: predicting drug-target interaction based on multi-source information and multi-head self-attention
Wenchuan Zhao,
Yufeng Yu,
Guosheng Liu
et al.
Abstract:Identifying drug-target interactions (DTIs) holds significant importance in drug discovery and development, playing a crucial role in various areas such as virtual screening, drug repurposing and identification of potential drug side effects. However, existing methods commonly exploit only a single type of feature from drugs and targets, suffering from miscellaneous challenges such as high sparsity and cold-start problems. We propose a novel framework called MSI-DTI (Multi-Source Information-based Drug-Target … Show more
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