msh/Msx gene family in neural development

Ramos, Casto; Robert, Benoît

doi:10.1016/j.tig.2005.09.001

Cited by 110 publications

(102 citation statements)

References 73 publications

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“…Solute carrier family 37 member 2 is homologous to the GlpT antiport sn-glycerol 3-phosphate transporter family in bacteria (Bartoloni et al 2000). Msx1 is a homeobox gene (Blin-Wakkach et al 2001, Ramos & Robert 2005. The genes identified in Table 4 are candidates for involvement in female sex determination and early gonadal development and should be considered for further investigation.…”

Section: Discussionmentioning

confidence: 99%

Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes

Clement

Anway²,

Uzumcu³

et al. 2007

Reproduction

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Gene expression profiles during sex determination and gonadal differentiation were investigated to identify new potential regulatory factors. Embryonic day 13 (E13), E14, and E16 rat testes and ovaries were used for microarray analysis, as well as E13 testis organ cultures that undergo testis morphogenesis and develop seminiferous cords in vitro. A list of 109 genes resulted from a selective analysis for genes present in male gonadal development and with a 1.5-fold change in expression between E13 and E16. Characterization of these 109 genes potentially important for testis development revealed that cytoskeletal-associated proteins, extracellular matrix factors, and signaling factors were highly represented. Throughout the developmental period (E13-E16), sexenriched transcripts were more prevalent in the male with 34 of the 109 genes having testis-enriched expression during sex determination. In ovaries, the total number of transcripts with a 1.5-fold change in expression between E13 and E16 was similar to the testis, but none of those genes were both ovary enriched and regulated during the developmental period. Genes conserved in sex determination were identified by comparing changing transcripts in the rat analysis herein, to transcripts altered in previously published mouse studies of gonadal sex determination. A comparison of changing mouse and rat transcripts identified 43 genes with species conservation in sex determination and testis development. Profiles of gene expression during E13-E16 rat testis and ovary development are presented and candidate genes for involvement in sex determination and testis differentiation are identified. Analysis of cellular pathways did not reveal any specific pathways involving multiple candidate genes. However, the genes and gene network identified influence numerous cellular processes with cellular differentiation, proliferation, focal contact, RNA localization, and development being predominant. Reproduction (2007) 134 455-472

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Section: Discussionmentioning

confidence: 99%

Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes

Clement

Anway²,

Uzumcu³

et al. 2007

Reproduction

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“…One candidate gene that may limit zic gene expression is the transcriptional repressor Msx1, which is directly induced by intermediate levels of BMP signaling. In Xenopus, Msx1 is expressed in the area of the prospective neural crest and in the epidermal ectoderm, ventrolateral to the neural crest region (Tribulo et al, 2003), where it acts as a ventralizing factor (Ramos and Robert, 2005). Msx1 represses zic gene expression in neuralized animal caps (ectodermal explants) of Xenopus (Feledy et al, 1999;Yamamoto et al, 2000;Monsoro-Burq et al, 2005).…”

Section: Regulation Of Zic Gene Expressionmentioning

confidence: 99%

Emerging roles for zic genes in early development

Merzdorf

2007

Developmental Dynamics

134

126

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“…At the molecular level, Msx/vab-15 establishes the identity of the lateral boundary of the neuroectoderm in fly, annelids, amphioxus, lamprey, and higher vertebrates. Also, their Msx/vab-15-expressing domains include both CNS and PNS progenitors (8,(11)(12)(13)(14). Worm Msx/vab-15 expression was observed in lateral P neuroblasts, progenitors of larval CNS motor neurons.…”

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confidence: 99%

Conserved gene regulatory module specifies lateral neural borders across bilaterians

Zhao

Horie

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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The lateral neural plate border (NPB), the neural part of the vertebrate neural border, is composed of central nervous system (CNS) progenitors and peripheral nervous system (PNS) progenitors. In invertebrates, PNS progenitors are also juxtaposed to the lateral boundary of the CNS. Whether there are conserved molecular mechanisms determining vertebrate and invertebrate lateral neural borders remains unclear. Using single-cell-resolution gene-expression profiling and genetic analysis, we present evidence that orthologs of the NPB specification module specify the invertebrate lateral neural border, which is composed of CNS and PNS progenitors. First, like in vertebrates, the conserved neuroectoderm lateral border specifier Msx/vab-15 specifies lateral neuroblasts in Caenorhabditis elegans. Second, orthologs of the vertebrate NPB specification module (Msx/vab-15, Pax3/7/pax-3, and Zic/ref-2) are significantly enriched in worm lateral neuroblasts. In addition, like in other bilaterians, the expression domain of Msx/vab-15 is more lateral than those of Pax3/7/pax-3 and Zic/ref-2 in C. elegans. Third, we show that Msx/vab-15 regulates the development of mechanosensory neurons derived from lateral neural progenitors in multiple invertebrate species, including C. elegans, Drosophila melanogaster, and Ciona intestinalis. We also identify a novel lateral neural border specifier, ZNF703/tlp-1, which functions synergistically with Msx/vab-15 in both C. elegans and Xenopus laevis. These data suggest a common origin of the molecular mechanism specifying lateral neural borders across bilaterians.C. elegans | neural plate border | neural border | Msx/vab-15 | ZNF703/tlp-1 T he vertebrate neural border is a transient embryonic domain located between the neural plate and nonneurogenic ectoderm from late gastrulation to early neurulation. The neural border is composed of the lateral neural plate border (NPB) and preplacode ectoderm (PPE) subdomains (1, 2). The NPB and PPE give rise to the neural crest and placode, respectively, both of which undergo epithelial-to-mesenchymal transition/delamination, migrate in prototypical paths, and give rise to the peripheral nervous system (PNS) and many other cell types (3, 4). However, the NPB and PPE also have many different features (5). For example, the PPE is confined to the anterior half of embryos and does not contribute to the central nervous system (CNS), whereas the NPB is the lateral border of the whole neural plate and consists not only of progenitors for the PNS but also those for the CNS in the dorsal neural tube. The juxtaposed localization of the CNS neuroectoderm and PNS progenitors also occurs in the trunk of invertebrate embryos such as nematodes, arthropods, annelids, and urochordates (6-9), reminiscent of vertebrate NPB. In Caenorhabditis elegans, lateral neuroblasts (P, Q, and V5 cells) are located between the embryonic CNS and skin from the birth of these cells (10). In addition, worm lateral neuroblasts possess several key cellular and developmental features of vertebra...

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msh/Msx gene family in neural development

Cited by 110 publications

References 73 publications

Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes

Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes

Emerging roles for zic genes in early development

Conserved gene regulatory module specifies lateral neural borders across bilaterians

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