MSG1(Melanocyte-Specific Gene 1): Mapping to Chromosome Xq13.1, Genomic Organization, and Promoter Analysis

Fenner, Martin; Parrish, Julia E.; Boyd, Yvonne; Reed, Vivienne; MacDonald, Marcy E.; Nelson, David L.; Isselbacher, Kurt J.; Shioda, Toshi

doi:10.1006/geno.1998.5383

Cited by 24 publications

(23 citation statements)

References 30 publications

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“…Like the murine gene, 2 human CITED4 is encoded by a single exon. This remarkably simple structure is reminiscent of CITED2, where the entire open reading frame of the p35srj isoform is contained within a single exon (8), and of CITED1, where the open reading frame is contained within 2 exons (30). Taken together with the presence of conserved regions at the amino and carboxyl termini of the CITED proteins, this suggests that the members of the CITED family have likely arisen by gene duplication and sequence divergence from an ancestral gene.…”

Section: Fig 4 Protein Interaction and Transactivation Domains In Cmentioning

confidence: 98%

Human CREB-binding Protein/p300-interacting Transactivator with ED-rich Tail (CITED) 4, a New Member of the CITED Family, Functions as a Co-activator for Transcription Factor AP-2

Bragança

Swingler

Marques

et al. 2002

Journal of Biological Chemistry

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Members of the CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) family bind CREB-binding protein and p300 with high affinity and regulate gene transcription. Gene knockout studies indicate that CITED2 is required for neural crest and neural tube development and that it functions as a co-activator for transcription factor AP-2 (TFAP2). Here we describe human CITED4, a new member of this family, which is encoded by a single exon mapping to chromosome 1p34 -1p35. CITED4 and p300/CREB-binding protein are present in endogenous naturally occurring complexes, indicating that they interact physiologically. The interaction occurs between the cysteine-histidinerich domain 1 of p300 and the carboxyl terminus of CITED4. In keeping with this, CITED4 functions as a transactivator when artificially targeted to a promoter element. CITED4 physically interacts with all TFAP2 isoforms in vitro and strongly co-activates all TFAP2 isoforms in Hep3B cells. Co-activation of TFAP2 requires amino-terminal and carboxyl-terminal residues of CITED4. In HepG2 cells, CITED4 is significantly weaker than CITED2 for TFAP2C co-activation. These results suggest that CITED4 may function as a co-activator for TFAP2. They also suggest the existence of cell type-and TFAP2 isoform-specific co-activation by CITED2 and CITED4, which may result in differential modulation of TFAP2 function.

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Section: Fig 4 Protein Interaction and Transactivation Domains In Cmentioning

confidence: 98%

Human CREB-binding Protein/p300-interacting Transactivator with ED-rich Tail (CITED) 4, a New Member of the CITED Family, Functions as a Co-activator for Transcription Factor AP-2

Bragança

Swingler

Marques

et al. 2002

Journal of Biological Chemistry

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“…In the mouse, Cited1 maps to the X chromosome at 40.1 centimorgans (cM) (20). Therefore, mice had to be intercrossed in two distinct ways to generate progeny that represent each possible genotype.…”

Section: Targeted Disruption Of Thementioning

confidence: 99%

Cited1 Is Required in Trophoblasts for Placental Development and for Embryo Growth and Survival

Rodríguez¹,

Sparrow²,

Scott³

et al. 2004

Molecular and Cellular Biology

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Cited1 is a transcriptional cofactor that interacts with Smad4, estrogen receptors ␣ and ␤, TFAP2, and CBP/p300. It is expressed in a restricted manner in the embryo as well as in extraembryonic tissues during embryonic development. In this study we report the engineering of a loss-of-function Cited1 mutation in the mouse. Cited1 null mutants show growth restriction at 18.5 days postcoitum, and most of them die shortly after birth. Half the heterozygous females, i.e., those that carry a paternally inherited wild-type Cited1 allele, are similarly affected. Cited1 is normally expressed in trophectoderm-derived cells of the placenta; however, in these heterozygous females, Cited1 is not expressed in these cells. This occurs because Cited1 is located on the X chromosome, and thus the wild-type Cited1 allele is not expressed because the paternal X chromosome is preferentially inactivated. Loss of Cited1 resulted in abnormal placental development. In mutants, the spongiotrophoblast layer is irregular in shape and enlarged while the labyrinthine layer is reduced in size. In addition, the blood spaces within the labyrinthine layer are disrupted; the maternal sinusoids are considerably larger in mutants, leading to a reduction in the surface area available for nutrient exchange. We conclude that Cited1 is required in trophoblasts for normal placental development and subsequently for embryo viability.

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“…The CITED1 gene encodes a 27-kDa protein belonging to the CITED (CBP/p300-Interacting Transactivators with glutamic acid [E] and aspartic acid [D]-rich C-terminal domain) family of nuclear proteins. 17 The CITED proteins are believed to coregulate nuclear transcription proteins. Initial studies demonstrated a possible role in melanocyte differentiation, hence the synonym MSG1 (melanocyte-specific gene 1).…”

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confidence: 99%

Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors

et al. 2005

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The diagnosis of thyroid tumors is critical for clinical management; however, tumors with follicular architecture often present problems. We evaluated the diagnostic use of the protein expression of four genes that were found to be upregulated in papillary thyroid carcinoma compared to normal thyroid (LGALS3, FN1, CITED1 and KRT19), and of the mesothelial cell surface protein recognized by monoclonal antibody HBME1 in thyroid tumors. Tissues from 85 carcinomas (67 papillary, six follicular, eight Hü rthle cell and four anaplastic) and 21 adenomas were evaluated by immunohistochemistry for the expression of these gene protein products, for example, galectin-3 (GAL3), fibronectin-1 (FN1), CITED1, cytokeratin-19 (CK19) and HBME1. Non-neoplastic thyroids (29 adenomatous and 14 thyrotoxic hyperplasia, and 59 normal) were also studied. The expression of all five proteins was significantly associated with malignancy, and highly specific (Z90%) for carcinoma compared to adenoma. GAL3, FN1 and/or HBME1 expression was seen in 100% of carcinomas (85/85) and in 24% of adenomas (5/21). Coexpression of multiple proteins was seen in 95% of carcinomas and only 5% of adenomas (Po0.0001). Coexpression of FN1 and GAL3 (FN1 þ GAL3 þ , 70/85) or FN1 and HBME1 (FN1 þ HBME1 þ , 53/85) was restricted to carcinomas, while their concurrent absence (FN1ÀGAL3À or FN1ÀHBME1À, 18/21 adenoma) was highly specific (96%) for benign lesions. Among non-neoplastic thyroids, adenomatous hyperplasia frequently expressed GAL3 (n ¼ 16), CK19 (n ¼ 9) and CITED1 (n ¼ 7), but the expression was predominantly focal in contrast to the diffuse expression in carcinomas. An immunohistochemical panel consisting of GAL3, FN1 and HBME1 may be useful in the diagnosis of follicular cell-derived thyroid tumors.

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MSG1(Melanocyte-Specific Gene 1): Mapping to Chromosome Xq13.1, Genomic Organization, and Promoter Analysis

Cited by 24 publications

References 30 publications

Human CREB-binding Protein/p300-interacting Transactivator with ED-rich Tail (CITED) 4, a New Member of the CITED Family, Functions as a Co-activator for Transcription Factor AP-2

Human CREB-binding Protein/p300-interacting Transactivator with ED-rich Tail (CITED) 4, a New Member of the CITED Family, Functions as a Co-activator for Transcription Factor AP-2

Cited1 Is Required in Trophoblasts for Placental Development and for Embryo Growth and Survival

Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors

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