MSCs exosomal miR-1470 promotes the differentiation of CD4+CD25+FOXP3+ Tregs in asthmatic patients by inducing the expression of P27KIP1

Zhuansun, Yongxun; Du, Yumo; Huang, Fengting; Lin, Lin; Chen, Rui; Jiang, Shanping; Li, Jianguo

doi:10.1016/j.intimp.2019.105981

Cited by 29 publications

(18 citation statements)

References 23 publications

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“…Chiou et al [ 162 ] demonstrated that after T cell activation, the EVs isolated from T cells contained tRNA fragments (tRFs), probably removing immune activation. Notably, the mesenchymal stem cell (MSC) generates exosomal miRNA-1470, which remains important in CD4 + CD25 + Foxp3 + Treg differentiation [ 163 ]. Du et al [ 164 ] proved that exosomes released from the MSC increased IL-10 and TGF- β 1, thus helping asthmatic patients restore Treg cell proliferation and immunosuppressive functions.…”

Section: Crosstalk Between T Cells and Macrophages In Asthma Pathomentioning

confidence: 99%

The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

Zhu

Cui

Liu

et al. 2020

Mediators of Inflammation

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Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis.

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Section: Crosstalk Between T Cells and Macrophages In Asthma Pathomentioning

confidence: 99%

The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

Zhu

Cui

Liu

et al. 2020

Mediators of Inflammation

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“…Furthermore, EVs deriving from mouse and human BM-MSCs turned out to ameliorate the mixed Th2/Th17 phenotype in an Aspergillus -induced mouse model of AAI reflective of severe refractory asthma [ 91 ]. In another in vitro study, miR-1470-containing exosomes from human MSCs were found to be able to promote the differentiation of Tregs among CD4 + T cells separated from PBMCs of acute asthmatic patients [ 92 ].…”

Section: Extracellular Vesicles and Asthma: Cellular Levelmentioning

confidence: 99%

Extracellular Vesicles and Asthma—More Than Just a Co-Existence

Alhamwe

Potaczek

Miethe

et al. 2021

IJMS

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Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process. Here we summarize their functional relevance in asthma, one of the most common chronic non-communicable diseases. Asthma is a complex persistent inflammatory disorder of the airways characterized by reversible airflow obstruction and, from a long-term perspective, airway remodeling. Overall, mechanistic studies summarized here indicate the importance of different subtypes of EVs and their variable cargoes in the functioning of the pathways underlying asthma, and show some interesting potential for the development of future therapeutic interventions. Association studies in turn demonstrate a good diagnostic potential of EVs in asthma.

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“…However, the promoting effects of MSC-EVs on Tregs could be partially mediated by their content in TGF-β signaling components ( Song et al, 2020 ). Another possible molecular mechanism is the transfer of miR-1470 from MSC-EVs to CD4 + T cells, thus upregulating P27KIP1 expression through c-Jun targeting ( Zhuansun et al, 2019 ). Other miRNAs have been described in this phenomenon, such as miR155-5p, miR-let7b, and miR-let7d.…”

Section: Msc-evs and Immunomodulationmentioning

confidence: 99%

Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells

Kamga

Tanasi

Krampera

2020

Front. Cell Dev. Biol.

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Mesenchymal stem/stromal cells (MSCs) are multipotent cells residing in the stromal tissues of the body and capable of promoting tissue repair and attenuating inflammatory processes through their immunomodulatory properties. Preclinical and clinical observations revealed that not only direct intercellular communication mediates MSC properties; in fact, a pivotal role is also played by the release of soluble and bioactive factors, such as cytokines, growth factor and extracellular vesicles (EVs). EVs are membrane-coated vesicles containing a large variety of bioactive molecules, including lipids, proteins, and nucleic acids, such as RNA. EVs release their contents into target cells, thus influencing cell fate through the control of intracellular processes. In addition, MSC-derived EVs can mediate modulatory effects toward different effector cells belonging to both innate and adaptive immunity. In this review, we will discuss the literature data concerning MSC-derived EVs, including the current standardized methods for their isolation and characterization, the mechanisms supporting their immunoregulatory properties, and their potential clinical application as alternative to MSC-based therapy for inflammatory reactions, such as graft-versus-host disease (GvHD).

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MSCs exosomal miR-1470 promotes the differentiation of CD4+CD25+FOXP3+ Tregs in asthmatic patients by inducing the expression of P27KIP1

Cited by 29 publications

References 23 publications

The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

Extracellular Vesicles and Asthma—More Than Just a Co-Existence

Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells

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