MSC-derived exosomal lncRNA SNHG7 suppresses endothelial-mesenchymal transition and tube formation in diabetic retinopathy via miR-34a-5p/XBP1 axis

Cao, Xin; Xue, Lidan; Di, Yue; Li, Tao; Tian, Ya-Jing; Song, You-Jin

doi:10.1016/j.lfs.2021.119232

Cited by 64 publications

(50 citation statements)

References 35 publications

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“…Moreover, lncRNAs carried by BM-MSC-derived sEVs have a beneficial effect on diabetic complications. The overexpression of HOTAIR in BM-MSC-produced sEVs enhanced angiogenesis and wound healing in a diabetic db/db mouse model [ 76 ], and BM-MSC-derived sEV lncRNA SNHG7 inhibited high glucose-induced proliferation and migration of retinal endothelial cells, which is a critical step in diabetic retinopathy development [ 77 ]. The effects of the MSC-sEV cargo also depend on cell status and the culture environment.…”

Section: Bone Marrow Cell-derived Sev Noncoding Rnas In Diabetesmentioning

confidence: 99%

Noncoding RNAs from tissue-derived small extracellular vesicles: Roles in diabetes and diabetic complications

Chang

Lin

et al. 2022

Molecular Metabolism

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Section: Bone Marrow Cell-derived Sev Noncoding Rnas In Diabetesmentioning

confidence: 99%

Noncoding RNAs from tissue-derived small extracellular vesicles: Roles in diabetes and diabetic complications

Chang

Lin

et al. 2022

Molecular Metabolism

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“…LncRNA UCA1 promoted TGF-β1-induced EndMT in human umbilical vein endothelial cells (HUVECs), and silencing of UCA1 prevented the EndMT process through the UCA1-miR-455-ZEB1 pathway [ 59 ]. Mesenchymal stem cells (MSCs)-derived exosomal lncRNA SNHG7 prevented high glucose-induced EndMT by sponging miR-34a-5p [ 60 ]. Many studies have shown that lncRNAs function as ceRNA in the pathogenesis of PH, but their functional role in the regulation of EndMT in PH is still unknown.…”

Section: Long Noncoding Rnas (Lncrnas) In Pulmonary Hypertensionmentioning

confidence: 99%

The Landscape of Noncoding RNA in Pulmonary Hypertension

et al. 2022

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The transcriptome of pulmonary hypertension (PH) is complex and highly genetically heterogeneous, with noncoding RNA transcripts playing crucial roles. The majority of RNAs in the noncoding transcriptome are long noncoding RNAs (lncRNAs) with less circular RNAs (circRNAs), which are two characteristics gaining increasing attention in the forefront of RNA research field. These noncoding transcripts (especially lncRNAs and circRNAs) exert important regulatory functions in PH and emerge as potential disease biomarkers and therapeutic targets. Recent technological advancements have established great momentum for discovery and functional characterization of ncRNAs, which include broad transcriptome sequencing such as bulk RNA-sequence, single-cell and spatial transcriptomics, and RNA-protein/RNA interactions. In this review, we summarize the current research on the classification, biogenesis, and the biological functions and molecular mechanisms of these noncoding RNAs (ncRNAs) involved in the pulmonary vascular remodeling in PH. Furthermore, we highlight the utility and challenges of using these ncRNAs as biomarkers and therapeutics in PH.

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“…Lymphocyte-derived exosomal microRNAs promote pancreatic β -cell death and may contribute to type 1 diabetes development [ 104 ]. Another study has shown that the MSC-derived exosomal lncRNA SNHG7 suppresses endothelial-mesenchymal transition and tube formation in DR via the miR-34a-5p/XBP1 axis [ 105 ]. These findings also make the clinical prospects of lncRNAs more extensive and far-reaching.…”

Section: The Role and Function Of Lncrnas In Diabetic Inflammationmentioning

confidence: 99%

Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus

Huang

2021

International Journal of Endocrinology

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Diabetes is a chronic inflammatory state, and several studies have shown that the mechanisms of insulin resistance and abnormal islet β-cell function in diabetes are closely related to inflammatory reactions. Inflammation plays a critical role in diabetic complications. Long noncoding RNAs (lncRNAs), a new area of genomic research for gene regulation, have complex biological functions in various aspects of cellular biological activity. Recent studies have shown that lncRNAs are associated with the regulation of inflammatory responses in various ways, including at the epigenetic, transcriptional, and posttranscriptional levels. This paper presents a brief review of studies on the mechanisms of lncRNAs in diabetic inflammation. The purpose of this article is to determine the role of lncRNAs in the process of diabetic inflammation and to provide new strategies for the use of lncRNAs in the treatments for diabetic inflammation.

show abstract

MSC-derived exosomal lncRNA SNHG7 suppresses endothelial-mesenchymal transition and tube formation in diabetic retinopathy via miR-34a-5p/XBP1 axis

Cited by 64 publications

References 35 publications

Noncoding RNAs from tissue-derived small extracellular vesicles: Roles in diabetes and diabetic complications

Noncoding RNAs from tissue-derived small extracellular vesicles: Roles in diabetes and diabetic complications

The Landscape of Noncoding RNA in Pulmonary Hypertension

Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus

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