MSBA-S – A pentacyclic sulfamate as a new option for radiotherapy of human breast cancer cells

Petrenko, Marina; Güttler, Antje; Pflüger, Elena; Serbian, Immo; Kahnt, Michael; Eiselt, Yvonne; Kessler, Jacqueline; Funtan, Anne; Paschke, Ralf; Csuk, René; Vordermark, Dirk; Bache, Matthias

doi:10.1016/j.ejmech.2021.113721

Cited by 12 publications

(7 citation statements)

References 36 publications

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“…In addition, 66 promoted ROS production, caused apoptosis, and dramatically decreased the survival rate of breast cancer cell clones. Consequently, 66 might represent a novel option for irradiation of breast cancer cells [75] (Figure 8).…”

Section: Structural Modification Of Mamentioning

confidence: 99%

Bioactivities and Structure‐Activity Relationships of Maslinic Acid Derivatives: A Review

Yan,

Liu,

Huang

et al. 2024

Chemistry & Biodiversity

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Maslinic acid has a variety of biological activities, such as anti‐tumor, hypoglycemic, anti‐inflammatory, and anti‐parasitic. In order to enhance the biological activity of maslinic acid, scholars have carried out a lot of structural modifications, and found some more valuable maslinic acid derivatives. In this paper, the structural modification, biological activity, and structure‐activity relationship of maslinic acid were reviewed, providing references for the development of maslinic acid.

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Section: Structural Modification Of Mamentioning

confidence: 99%

Bioactivities and Structure‐Activity Relationships of Maslinic Acid Derivatives: A Review

Yan,

Liu,

Huang

et al. 2024

Chemistry & Biodiversity

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“…They target various genes and pathways such as Bcl-2, NF-kB, and PI3K/Akt/mTOR, as reviewed in ref. 33 . Indication that such triterpenoids also affect phospholipid biosynthesis (PLB) has been provided by micelle models mimicking mitochondrial membranes, where membrane rigidification and increased membrane permeabilization were induced in dose-dependent manner 34 .…”

Section: Inhibition Of Mitochondrial Functions Produces Distinctive M...mentioning

confidence: 99%

Machine Learning-Based Metabolic Pattern Recognition Predicts Mode of Action for Anti-Cancer Drug Candidates

Balcke,

Saoud,

Grau

et al. 2024

Preprint

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A bottleneck in the development of new anti-cancer drugs is the recognition of their mode of action (MoA). We combined metabolomics and machine learning to predict MoAs of novel anti-proliferative drug candidates, focusing on human prostate cancer cells (PC-3). As proof of concept, we studied 38 drugs with known effects on 16 key processes of cancer metabolism, profiling low molecular weight intermediates of the central carbon and cellular energy metabolism (CCEM) by LC-MS/MS. These metabolic patterns unveiled distinct MoAs, enabling accurate MoA predictions for novel agents by machine learning. We validate the transferability of MoA predictions from PC-3 to two other cancer cell models and show that correct predictions are still possible, but at the expense of prediction quality. Furthermore, metabolic profiles of treated cells yield insights into intracellular processes, exemplified for drugs inducing different types of mitochondrial dysfunction. Specifically, we predict that pentacyclic triterpenes inhibit oxidative phosphorylation and affect phospholipid biosynthesis, as supported by respiration parameters, lipidomics, and molecular docking. Using biochemical insights from individual drug treatments, our approach offers new opportunities, including the optimization of combinatorial drug applications.

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“…27,28 We have reviewed platanic acid, besides other triterpenoids, and its selected nitrogen-group-bearing derivatives recently. 3 Nevertheless, before the review paper has been published, several new papers have appeared in the literature: pentacyclic triterpenoid sulphamates used for radiotherapy of breast cancer, 29 nitrogen-group-bearing bicyclic compounds used as inhibitors of butyrylcholinesterase, 30,31 pyridinylidene derivatives developed for targeting apoptosis, 32 platanic acid amides 33,34 and even more complex derivatives of platanic acid 35 for investigating cytotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Oxime derivatives of betulonic acid and platanic acid as novel cytotoxic or antiviral agents

Černá,

Bildziukevich,

Rárová

et al. 2024

React. Chem. Eng.

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MSBA-S – A pentacyclic sulfamate as a new option for radiotherapy of human breast cancer cells

Cited by 12 publications

References 36 publications

Bioactivities and Structure‐Activity Relationships of Maslinic Acid Derivatives: A Review

Bioactivities and Structure‐Activity Relationships of Maslinic Acid Derivatives: A Review

Machine Learning-Based Metabolic Pattern Recognition Predicts Mode of Action for Anti-Cancer Drug Candidates

Oxime derivatives of betulonic acid and platanic acid as novel cytotoxic or antiviral agents

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