MSA capped CdTe quantum dots for pH sensing application

Nideep, T. K.; Ramya, M.; Udayan, Sony; Kailasnath, M.

doi:10.1088/2053-1591/ab35a0

Cited by 11 publications

(3 citation statements)

References 46 publications

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“…Apart from the four additives (sodium citrate, citric acid, d , l -malic acid, and KH 2 PO 4 ) for the purpose of foods acidity regulation, almost all others showed no obvious impact, even at their maximum legal dosages (based on Chinese food standard GB 2760-2021, “Food Safety National Standard for the Usage of Food Additives”) or the concentration as high as 50.0 mg/mL, suggesting the acid responsiveness and acceptable fluorescent anti-interference ability of indicator papers (see Figures S5A and S5B in the Supporting Information). The pH sensitivity of fluorescent indicator papers was further affirmed by the investigation of pH effect, and a sharp decline in fluorescence intensity could be observed when the pH value was <6.0 or >11.0 as system pH varied from 2.0 to 13.0 (see Figures S5C and S5D in the Supporting Information), which was in good agreement with literature reports. − Moreover, the effect of alcoholicity on fluorescence of indicator papers was also not apparent, giving a falloff in fluorescence intensity of <13.4%, even the alcoholicity as high as 30% (see Figures S5E and S5F in the Supporting Information), which suggested that indicator papers would be qualified for the detection of FDs in common hard drinks, since such an alcohol content covers the alcoholicity of most marketed hard drinks.…”

Section: Resultssupporting

confidence: 89%

Colorimetry Combined with Inner Filter Effect-Based Fluorometry: A Versatile and Robust Strategy for Multimode Visualization of Food Dyes

Wang

Yuan

et al. 2022

ACS Appl. Mater. Interfaces

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Herein, a strategy combining colorimetry and inner filter effect (IFE)-based fluorometry was developed for multimode visualization of food dyes (FDs) using CdTe quantum-dots-doped fluorescent indicator papers as a sample-to-answer device. Colorimetry was straightforwardly achieved by FDs extraction through electrostatic interaction and hydrophobic effect while fluorometry was implemented by IFE-induced fluorescence quenching. RGB/gray-scale values of colorimetry and fluorometry were furtherly picked by a smartphone application and applied to reconstruct color information-based digital image analysis for both direct alignments and linear regression analysis. The apparent color and fluorescence of FDs-bound indicator papers, together with their digitized color information, showed a good mapping to FDs concentrations in the range of 0–0.5 mg/mL for Sunset Yellow, 0–0.2 mg/mL for Allura Red, and 0–0.08 mg/mL for Brilliant Blue. As a proof of concept, the dosages of these FDs in real beverages and simulated dye effluents were deduced and cross-validated by different visualization modes, and finally double-checked by instrumental techniques such as spectrometric methods, high-performance liquid chromatography (HPLC), and mass spectroscopy (MS). The above findings concluded that (i) IFE mechanism is generally applicable to build fluorometric systems and (ii) cross validation of different visualization modes can markedly improve detection accuracy, which may provide references for design and fabrication of novel “lab-on-paper” devices for visualization applications with high reliability.

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Section: Resultssupporting

confidence: 89%

Colorimetry Combined with Inner Filter Effect-Based Fluorometry: A Versatile and Robust Strategy for Multimode Visualization of Food Dyes

Wang

Yuan

et al. 2022

ACS Appl. Mater. Interfaces

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“…76 In another area, Nideep et al designed pH biosensor based on CdTe QDs capped with mercaptosuccinic acid (MSA) for fluorescence-based pH measurement within the range of 3-11. 77 Zhang and Chen fabricated a hybrid biosensor system based on ZnS: Mn QDs/ mesoporous silica/molecularly imprinted polymer (QD/ MS/MIP) for the therapeutic monitoring of the antibiotic, tetracycline, in serum samples via a linear quenching of fluorescence intensity upon binding the target compound. 78 Numerous similar approaches have been developed for the estimation of other antibiotics including quinolones, amoxicillin, cephalexin, and streptomycin.…”

Section: Dovepressmentioning

confidence: 99%

Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential

Abdellatif¹,

Younis²,

Alsharidah³

et al. 2022

IJN

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Despite the massive advancements in the nanomedicines and their associated research, their translation into clinicallyapplicable products is still below promises. The latter fact necessitates an in-depth evaluation of the current nanomedicines from a clinical perspective to cope with the challenges hampering their clinical potential. Quantum dots (QDs) are semiconductors-based nanomaterials with numerous biomedical applications such as drug delivery, live imaging, and medical diagnosis, in addition to other applications beyond medicine such as in solar cells. Nevertheless, the power of QDs is still underestimated in clinics. In the current article, we review the status of QDs in literature, their preparation, characterization, and biomedical applications. In addition, the market status and the ongoing clinical trials recruiting QDs are highlighted, with a special focus on the challenges limiting the clinical translation of QDs. Moreover, QDs are technically compared to other commercially-available substitutes. Eventually, we inspire the technical aspects that should be considered to improve the clinical fate of QDs.

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“…Most of them cannot investigate the living cells in an appropriate pH range (from 4 to 8). Semiconducting QDs have been proven to determine intracellular pH by fluorescence lifetime [41,57]. CDs benefits over QDs for their easy synthesis, low cytotoxicity and good optical properties [58].…”

Section: Fluorescence Characteristics Of Cds In Different Ph Solutionsmentioning

confidence: 99%

Carbon Dots for Intracellular pH Sensing with Fluorescence Lifetime Imaging Microscopy

et al. 2020

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The monitoring of intracellular pH is of great importance for understanding intracellular trafficking and functions. It has various limitations for biosensing based on the fluorescence intensity or spectra study. In this research, pH-sensitive carbon dots (CDs) were employed for intracellular pH sensing with fluorescence lifetime imaging microscopy (FLIM) for the first time. FLIM is a highly sensitive method that is used to detect a microenvironment and it can overcome the limitations of biosensing methods based on fluorescence intensity. The different groups on the CDs surfaces changing with pH environments led to different fluorescence lifetime values. The CDs aqueous solution had a gradual change from 1.6 ns to 3.7 ns in the fluorescence lifetime with a pH range of 2.6–8.6. Similar fluorescence lifetime changes were found in pH buffer-treated living cells. The detection of lysosomes, cytoplasm, and nuclei in living cells was achieved by measuring the fluorescence lifetime of CDs. In particular, a phasor FLIM analysis was used to improve the pH imaging. Moreover, the effects of the coenzymes, amino acids, and proteins on the fluorescence lifetime of CDs were examined in order to mimic the complex microenvironment inside the cells.

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MSA capped CdTe quantum dots for pH sensing application

Cited by 11 publications

References 46 publications

Colorimetry Combined with Inner Filter Effect-Based Fluorometry: A Versatile and Robust Strategy for Multimode Visualization of Food Dyes

Colorimetry Combined with Inner Filter Effect-Based Fluorometry: A Versatile and Robust Strategy for Multimode Visualization of Food Dyes

Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential

Carbon Dots for Intracellular pH Sensing with Fluorescence Lifetime Imaging Microscopy

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