Ms418 an Improved Device to Reproduce in Vitro the Pulsatile Coronary Flow Conditions Measured in Humans

Chodzynski, Kamil; Boudjeltia, Karim Zouaoui; Coussement, Grégory; Lalemand, J; Vanhaeverbeek, Michel

doi:10.1016/s1567-5688(10)70919-3

Cited by 1 publication

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“…Pressure sensors (First Sensor CTE8001GY4N and CTEM8500GY4N) are placed at each exit to monitor instantaneous pressure. To reproduce the owrate, a UMONS patented system of pulsatile pump consisting of a centrifugal rotative pump in series with a piston pump has been exploited to reproduce physiological ow conditions [14]. Distilled water was chosen in this study as the difference with blood provides minimal differences in the aortic arch dynamics (the non-newtonian behavior is assumed to be negligible considering the diameter of the main arteries) and for its convenience and optic properties.…”

Section: Methodsmentioning

confidence: 99%

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Distribution of Artificial Thrombi Candidates Through Patient-Specific Aortic-Arch Phantoms under Pulsatile Flow Conditions

Testaguzza¹,

Benhassine²,

Frid³

et al. 2021

Preprint

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Ischemic Stroke is the most frequent type of stroke and is subject to many studies investigating prevention means. Avoiding the difficulties and ethical problems of experimental in-vivo research, in-vitro testing is a convenient way of studying in controlled conditions the morphological impact and mechanical aspects of emboli dynamics. This in-vitro study was performed with two realistic silicone aortic-arch phantoms submitted to physiological pulsatile flow conditions. In the in-vitro test bed, using automatic image tracking and analysis, it was made possible detecting and tracking artificial spherical emboli candidates circulating in the anatomic aortic-arch models under a realistic based-patient blood flow profile. The emboli trajectories as well as their repartition in the different supra-aortic branches are presented for the two aortic-arch geometries obtained from CT scans. Through a statistical analysis performed with several artificial emboli sizes, the experimental study shows that the repartition percentages of the emboli closely follow the flowrate repartition percentages for both aortic-arch models, suggesting that higher flowrates lead to higher concentrations of emboli in a given artery. Sets of human thrombi were also injected and the repartition percentages have been established, giving the same trend as for artificial emboli.

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Section: Methodsmentioning

confidence: 99%

“…A UMONS patented system of pumps was exploited to reproduce the behavior of the physiological pulsatile owrate pro le [14]. The technology consisted of a centrifugal pump (Brushless DC Motor Water Pump DKB60TSA 24V) and a piston pump driven by a linear actuator.…”

Section: Physiological Flow Reproductionmentioning

confidence: 99%