MS-Based Metabolomics for the Investigation of Neuro-Metabolic Changes Associated with BDE-47 Exposure in C57BL/6 Mice

Ji, Fenfen; Luan, Hemi; Huang, Yu; Cai, Zongwei; Li, Min

doi:10.1007/s41664-017-0026-4

Cited by 12 publications

(2 citation statements)

References 36 publications

(39 reference statements)

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“…The detailed instrument conditions were set as previously reported. 24 To achieve relatively more comprehensive results, the samples were analyzed under both negative and positive ionization modes. Ten microliters of each sample was injected for analysis.…”

Section: Materials and Experimentsmentioning

confidence: 99%

“…Profiling of the metabolites was conducted on a LC-Q Exactive Focus Hybrid Quadrupole-Orbitrap Mass Spectrometer (Thermo Fisher Scientific Inc. USA). The detailed instrument conditions were set as previously reported . To achieve relatively more comprehensive results, the samples were analyzed under both negative and positive ionization modes.…”

Section: Materials and Experimentsmentioning

confidence: 99%

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Integrated Proteomics and Metabolomics Assessment Indicated Metabolic Alterations in Hypothalamus of Mice Exposed to Triclosan

Wei

Zhu

Cao

et al. 2021

Chem. Res. Toxicol.

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Triclosan (TCS) is a ubiquitous antimicrobial used in many daily consumer products. It has been reported to induce endocrine disrupting effects at low doses in mammals, disturbing sex hormone function and thyroid function. The hypothalamus plays a crucial role in the maintenance of neuroendocrine function and energy homeostasis. We speculated that the adverse effects of TCS might be related to the disturbance of metabolic processes in hypothalamus. The present study aimed at investigating the effects of TCS exposure on the protein and metabolite profiles in hypothalamus of mice. Male C57BL/6 mice were orally exposed to TCS at the dosage of 10 mg/kg/d for 13 weeks. The hypothalamus was isolated and processed for mass spectrometry (MS)-based proteomics and metabolomics analyses. The results showed that a 10.6% decrease (P = 0.066) in body weight gain was observed in the TCS exposure group compared with vehicle control group. Differential analysis defined 52 proteins and 57 metabolites that delineated TCS exposed mice from vehicle controls. Among the differential features, multiple proteins and metabolites were found to play vital roles in neuronal signaling and function. Bioinformatics analysis revealed that these differentially expressed proteins and metabolites were involved in four major biological processes, including glucose metabolism, purine metabolism, neurotransmitter release, and neural plasticity, suggesting the disturbance of homeostasis in energy metabolism, mitochondria function, neurotransmitter system, and neuronal function. Our results may provide insights into the neurotoxicity of TCS and extend our understanding of the biological effects induced by TCS exposure.

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Section: Materials and Experimentsmentioning

confidence: 99%

Section: Materials and Experimentsmentioning

confidence: 99%

Integrated Proteomics and Metabolomics Assessment Indicated Metabolic Alterations in Hypothalamus of Mice Exposed to Triclosan

Wei

Zhu

Cao

et al. 2021

Chem. Res. Toxicol.

Self Cite

View full text Add to dashboard Cite

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Bacteria from the rhizosphere of a selenium hyperaccumulator plant can improve the selenium uptake of a non-hyperaccumulator plant

Zhang,

Yang,

et al. 2024

Biol Fertil Soils

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Metabolomics strategies and analytical techniques for the investigation of contaminants of industrial origin

Aznar-Alemany

Llorca

2020

Environmental Metabolomics

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MS-Based Metabolomics for the Investigation of Neuro-Metabolic Changes Associated with BDE-47 Exposure in C57BL/6 Mice

Abstract: potential for molecular understanding of metabolic regulation linked to the exposure of environment pollutants.

Cited by 12 publications

References 36 publications

Integrated Proteomics and Metabolomics Assessment Indicated Metabolic Alterations in Hypothalamus of Mice Exposed to Triclosan

Integrated Proteomics and Metabolomics Assessment Indicated Metabolic Alterations in Hypothalamus of Mice Exposed to Triclosan

Bacteria from the rhizosphere of a selenium hyperaccumulator plant can improve the selenium uptake of a non-hyperaccumulator plant

Metabolomics strategies and analytical techniques for the investigation of contaminants of industrial origin

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