MS and neuromyelitis optica in Martinique (French West Indies)

Cabre, Philippe; Heinzlef, Olivier; Merle, H.; Buisson, G; Béra, Odile; Bellance, Rémi; Vernant, Jean‐Claude; Smadja, Didier

doi:10.1212/wnl.56.4.507

Cited by 147 publications

(111 citation statements)

References 39 publications

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“…In that report, more African Americans had early pyramidal system involvement than Caucasians, leading to greater EDSS scores, while the rates of disease progression at later stages were nearly identical. Since Africans and their descendants are known to preferentially show opticospinal involvement (14,15), it is possible that early deterioration is universally characteristic of OS-MS, regardless of race.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Clinical Courses of the Opticospinal and Conventional Forms of Multiple Sclerosis in Japan

et al. 2005

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We evaluated the clinical courses of 216 patients with multiple sclerosis (MS) diagnosed according to the recommended diagnostic criteria of McDonald et al (10). Sixty-five patients clinically displaying selective involvement of the optic nerves and spinal cord were classified as opticospinal MS (OS-MS), while the other 151 showing disseminated involvement of the central nervous system were classified as conventional MS (C-MS). The disease duration did not differ significantly between the two subtypes (11.2 years vs. 11.5 years). In addition to a higher age of onset, female preponderance and higher Kurtzke's expanded disability status scale (EDSS) scores, the OS-MS patients showed a markedly lower frequency of secondary progressive MS than the C-MS patients (4.6% vs. 29.1%, p=0.0001). The EDSS scores of the C-MS patients were significantly correlated with the disease duration, while those of the OS-MS patients were not. Among the C-MS patients, the frequency of secondary progressive MS was significantly more common in patients with a disease duration of more than 10 years than in those with a shorter duration. These results suggest that the irreversible disability in OS-MS is determined by relapses, rather than by chronic progression, whereas C-MS has a similar clinical course to MS in Westerners. (Internal Medicine 44: 934-938, 2005)

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Section: Discussionmentioning

confidence: 99%

Comparison of the Clinical Courses of the Opticospinal and Conventional Forms of Multiple Sclerosis in Japan

et al. 2005

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“…[1][2][3][4] NMO is a B-cell-mediated inflammatory and demyelinating disorder of the central nervous system, often presenting with severe and bilateral recurrent optic neuritis and transverse myelitis that are radiological distinguished from multiple sclerosis (MS). 5,6 Early detection of NMO is facilitated by the testing for the neuromyelitis optica immunoglobulin G (NMO-IgG) antibody.…”

Section: Case Reportmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorder in a Chinese Woman with Ocular Myasthenia Gravis: First Reported Case in the Chinese Population

Yau

Lee

Chan

et al. 2014

Neuro-Ophthalmology

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Coexisting myasthenia gravis and neuromyelitis optica spectrum disorder was reported as a rare association, with only 26 reported cases in the literature. The authors report the case of a middle-aged Chinese woman with bilateral recurrent optic neuritis and seropositive ocular myasthenia gravis who was subsequently diagnosed with neuromyelitis optica spectrum. She was tested seropositive for the neuromyelitis optica immunoglobulin G (NMO-IgG) and had elevated antinuclear antibody titres, but workup for other autoimmune disorders were negative. She was subsequently prescribed with azathioprine and pyridostigmine, and showed good control of both autoimmune disorders. To the best of the authors' knowledge, this is the first reported case in the literature of a Chinese patient with seropositivity for both anti-acetylcholine receptor and NMO-IgG without a thymic disorder. Testing of NMO-IgG may be considered in patients with optic neuritis with underlying autoimmune disorders even in the absence of transverse myelitis for the detection of associated neuromyelitis optica spectrum disorders.

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Section: Neuromyelitis Opticamentioning

confidence: 99%

“…NMO is rare and accounts for only 1% of all demyelinating diseases [26][27][28]. The incidence of NMO is estimated to be approximately 4 per million of the population and the prevalence is somewhere between 3 and 44 per million, depending on ethnicity and geographic location [26][27][28][29]. Disease onset is usually in the fourth decade of life; women are affected more commonly than men (approximately 3:1); and non-Caucasians (especially Japanese) are affected more commonly than Caucasians [29][30][31][32].…”

Section: Neuromyelitis Opticamentioning

confidence: 99%

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

Geldern¹,

McPharlin

Becker

2012

Neurotherapeutics

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This chapter will review the spectrum of immunemediated diseases that affect the nervous system and may result in an admission to the neurological intensive care unit. Immunomodulatory strategies to treat acute exacerbations of neurological diseases caused by aberrant immune responses are discussed, but strategies for long-term immunosuppression are not presented. The recommendations for therapeutic intervention are based on a synthesis of the literature, and include recommendations by the Cochrane Collaborative, the American Academy of Neurology, and other key organizations. References from recent publications are provided for the disorders and therapies in which randomized clinical trials and large evidenced-based reviews do not exist. The chapter concludes with a brief review of the mechanisms of action, dosing, and side effects of commonly used immunosuppressive strategies in the neurocritical care unit.

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MS and neuromyelitis optica in Martinique (French West Indies)

Cited by 147 publications

References 39 publications

Comparison of the Clinical Courses of the Opticospinal and Conventional Forms of Multiple Sclerosis in Japan

Comparison of the Clinical Courses of the Opticospinal and Conventional Forms of Multiple Sclerosis in Japan

Neuromyelitis Optica Spectrum Disorder in a Chinese Woman with Ocular Myasthenia Gravis: First Reported Case in the Chinese Population

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

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