MS-325: A small-molecule vascular imaging agent for magnetic resonance imaging

Lauffer, Randall B.; Parmelee, David J.; Ouellet, Huillori S.; Dolan, Robert; Sajiki, Hironao; Scott, Daniel M.; Bernard, Paul J.; Buchanan, Erin Michelle; Ong, Karen Y.; Tyeklár, Zoltán; Midelfort, Katarina; McMurry, Thomas J.; Walovitch, Richard C.

doi:10.1016/s1076-6332(96)80583-6

Cited by 108 publications

(63 citation statements)

References 2 publications

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“…The binding to human serum albumin reduces the extravasation of the contrast agent out of the vascular system and also leads to a high increase in relaxivity. Due to these properties MS-325 provides strong, persistent enhancement of blood vessel images (Lauffer et al 1996;Grist et al 1998). Other attempts to design blood pool contrast agents include synthesis of macromolecular gadolinium(III) chelates such as dendrimers, linear polymers, or proteins, which stay confined into blood vessels because of their large size.…”

Section: Introductionmentioning

confidence: 99%

Paramagnetic liposomes containing amphiphilic bisamide derivatives of Gd-DTPA with aromatic side chain groups as possible contrast agents for magnetic resonance imaging

et al. 2005

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Three amphiphilic DTPA bisamide derivatives containing long-chain phenylalanine esters (with 14, 16 and 18 carbon atoms in the alkyl chain) were synthesized and their corresponding gadolinium(III) complexes were prepared. The attempts to form paramagnetic micelles carrying the gadolinium(III) complexes yielded unstable or polydisperse micelles implying that the presence of the bulky aromatic side groups in the amphiphilic Gd-DTPA bisamide complexes results in an inefficient packing of the paramagnetic complex into micelles. All complexes were efficiently incorporated into liposomes consisting of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), yielding stable and monodisperse paramagnetic liposomes. All liposomes had a comparable size, typically between 120 and 160 nm. As a result of the reduced mobility of the gadolinium(III) complexes, solutions of these supramolecular structures show a higher relaxivity than solutions of Gd-DTPA. However, the relaxivity gain is lower compared to compounds consisting of purely aliphatic chains of the same length, most likely due to the less efficient packing or increased local mobility of the gadolinium(III) complex. In the case of the Gd-DTPA bisamide complex with 18 carbon atoms, the immobilization inside the liposomal structure is less effective, probably because the aliphatic chains of the complex are longer than the alkyl chains of the DPPC host, resulting in a relatively high local mobility. The paramagnetic liposomes containing the Gd-DTPA bisamide complexes with 14 carbon atoms showed the highest relaxivity because the optimal length match between the hydrophobic chains of the DPPC and the ligand allowed very efficient packing of the paramagnetic complex into the liposome.

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Section: Introductionmentioning

confidence: 99%

Paramagnetic liposomes containing amphiphilic bisamide derivatives of Gd-DTPA with aromatic side chain groups as possible contrast agents for magnetic resonance imaging

et al. 2005

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“…17 Second, there is still no agreement on the definition of recurrence after aneurysm coiling. 42,48 Third, even if one might suspect that an important marker of failure of aneurysm therapy is the need for retreatment, this necessity is currently not something that can be objectively measured. Rather, the decision to retreat is quite subjective in many cases as noted by Cloft et al 47 Regardless, the aim of our study was to compare 2 imaging techniques using the scale of Raymond et al and not to evaluate the therapeutic relevance of this classification.…”

Section: Raymond Et Almentioning

confidence: 99%

“…Its blood retention time is substantially prolonged. 38,[42][43][44][45] To our knowledge, this is the first report to address the role of BPCM for the follow-up of intracranial aneurysms after endovascular therapy. Our hypothesis was that they may be superior in contrasting vessels with slow or complex flow, like aneurysm remnants.…”

mentioning

confidence: 93%

MR Angiographic Follow-Up of Intracranial Aneurysms Treated with Detachable Coils: Evaluation of a Blood-Pool Contrast Medium

Kau¹,

Gasser²,

Celedin³

et al. 2009

AJNR Am J Neuroradiol

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“…intravenous use with a prolonged intravascular half-life secondary to its reversible binding to serum albumin and resultant increase in molecule size. 9 Gadofosveset trisodium is currently used as a blood pool agent for MR angiography studies with similar safety profile to existing clinically available Gd chelates. 10 Herborn et al evaluated the pre-FDA-approved version of gadofosveset trisodium (known as MS-325) for interstitial lymphography in a rabbit model and reported its utility in visualizing lower extremity and abdominal lymphatic vessels and lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Lymphography of the Thoracic Duct after Interstitial Injection of Gadofosveset Trisodium: A Pilot Dosing Study in a Porcine Model

Türkbey

Kobayashi²,

Hoyt³

et al. 2014

Lymphatic Research and Biology

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Background-rationale: To investigate whether interstitial injection of gadofosveset trisodium (AblavarÒ, Lantheus Medical, North Billerica, MA) would be suitable for thoracic duct (TD) imaging in a pig model. Methods and Results: Gadofosveset trisodium alone or premixed with 10% human serum albumin (HSA) was administered intradermally in the extremities of pigs at varying doses to visualize the TD by MRI. Two blinded readers evaluated MRIs for TD visibility. The inter-observer variability for all MR imaging sessions was assessed using the Spearman rank correlation test. MR lymphography using gadofosveset trisodium premixed with HSA yielded superior visualization of the TD compared to gadofosveset trisodium alone, with a high inter-observer agreement (correlation coefficient of 0.88 ( p = 0.00000115)). Conclusions: We demonstrate that gadofosveset trisodium (premixed with 10%HSA) can be injected intradermally in order to perform MR lymphography of the thoracic duct. Since this agent is already FDA approved for MR imaging, the off-label use of it for imaging of the thoracic duct in humans is feasible, and the approach may prove to be beneficial for patients with TD abnormalities.

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MS-325: A small-molecule vascular imaging agent for magnetic resonance imaging

Cited by 108 publications

References 2 publications

Paramagnetic liposomes containing amphiphilic bisamide derivatives of Gd-DTPA with aromatic side chain groups as possible contrast agents for magnetic resonance imaging

Paramagnetic liposomes containing amphiphilic bisamide derivatives of Gd-DTPA with aromatic side chain groups as possible contrast agents for magnetic resonance imaging

MR Angiographic Follow-Up of Intracranial Aneurysms Treated with Detachable Coils: Evaluation of a Blood-Pool Contrast Medium

Magnetic Resonance Lymphography of the Thoracic Duct after Interstitial Injection of Gadofosveset Trisodium: A Pilot Dosing Study in a Porcine Model

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