MRSA outbreak at a transplantation unit

Romanelli, Roberta Maia de Castro; Clemente, Wanessa Trindade; Lima, Stella Sala Soares; Rezende, Edna Maria; Martinho, Gláucia Helena; Paiva, Luciene F.; Neves, Francelli Cordeiro; Madeira, Jovita Gazzinelli Cruz; Amâncio, G.C.S.; Lima, Agnaldo Soares; Faria, Luciana Costa; Coutinho, Rosane Luiza

doi:10.1590/s1413-86702010000100011

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…MRSA colonization is generally seen as a factor strongly related to infection in post-LT. 61 – 64 Other risk factors for MRSA infection after LT are listed as follows: alcoholic cirrhosis, decreased prothrombin ratio, presence of central lines, being intubated, immunosuppressed status, multiple admissions to the intensive care unit, retransplantation and prolonged hospitalization. 4 , 23 , 24 , 40 , 58 , 61 Additionally, risk factors such as age 60 years or greater, preoperative use of antimicrobials, operation time (>16 hours) and perioperative dialysis and/or apheresis are also known to increase the risk of MRSA infection.…”

Section: Methodsmentioning

confidence: 99%

<div>Methicillin-resistant <em>Staphylococcus aureus</em> bacteremia among liver transplant recipients: epidemiology and associated risk factors for morbidity and mortality</div>

Liu¹,

Zhang²,

Wan³

2018

IDR

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Bacteremia due to Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), complicates the clinical course of liver transplantation and is associated with high morbidity and mortality. Intravascular catheters had been reported to be the most frequent source of MRSA bacteremia. Among bacteremic liver recipients, 26.3%–100% of S. aureus were MRSA. Previous studies identified pre-transplant and post-transplant acquired S. aureus carriage, greater severity of liver disease, hepatocellular carcinoma and infection with immuno-modulatory viruses as predictors of S. aureus bacteremia in liver recipients. MRSA bacteremia accompanied by pneumonia and abdominal infections was related to mortality. Vancomycin, as well as daptomycin, is a first-line antibiotic for MRSA bacteremia. The purpose of this review is to better understand the characteristics of MRSA bacteremia by summarizing the epidemiology and antimicrobial resistance of S. aureus, the primary source, and related risk factors for morbidity and mortality of MRSA bacteremia. We have also explored the diagnostic, therapeutic and preventive measures for MRSA bacteremia to improve the outcomes of liver recipients.

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Section: Methodsmentioning

confidence: 99%

<div>Methicillin-resistant <em>Staphylococcus aureus</em> bacteremia among liver transplant recipients: epidemiology and associated risk factors for morbidity and mortality</div>

Liu¹,

Zhang²,

Wan³

2018

IDR

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“…Previous studies have shown that MRSA colonization in cirrhotic patients varies from 16 to 28 % and that MRSA colonization can be associated with a high risk for infection in post liver transplantation patients [ 11 – 14 ]. In spite of this, few studies evaluated the molecular characterization of MRSA in liver transplantation patients, most of them described outbreaks, only pvl was evaluated among the virulence factors, and no study compared PFGE with spa typing [ 14 – 16 ]. To our knowledge, this is the first prospective study of molecular characterization of MRSA isolates in patients before and after liver transplantation.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus isolates colonizing and infecting cirrhotic and liver-transplantation patients: comparison of molecular typing and virulence factors

Oliveira

Heijden

Golding³

et al. 2015

BMC Microbiol

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BackgroundS. aureus is an important agent of colonization and infection in liver transplant patients. It harbors several virulence factors that can increase its pathogenicity. However, studies of virulence and molecular typing of MRSA in cirrhotic and liver transplantation patients are scarce.ResultsHere we use SCCmec, PFGE, spa typing, MLST and virulence factors to characterize MRSA isolates in pre and post liver transplantation patients. Sixteen (13 %) of 126 cirrhotic and 15 of the 64 liver-transplanted patients (23 %) were colonized by MRSA (p = 0.091). SCCmec types I, II and III that are generally associated with nosocomial infections were identified in 91 % of the isolates. None of the isolates carried PVL, adhesion factors and fib gene. Only three MRSA colonized isolates carried tst gene and were characterized as SCCmec type I and t149. Ten spa types and five STs were identified; t002 and ST105 were the most frequent profiles. Spa types and ST1510 never described in Brazil and a new spa type t14789 were identified. Nineteen PFGE subtypes were found and grouped into nine types. There was a predominant cluster, which was related to the New York/Japanese epidemic clone and harboured SCCmec type II identified in both cirrhotic and post-transplantation patients. Based on SCCmec and virulence factors the MRSA isolates belonged to NY/Jpn clone seen be more similar to the USA100 MRSA isolates.ConclusionsAlthough without significance, liver-transplantation was more frequently colonized by MRSA than cirrhotic patients. The most frequent SCCmec was type II, and the predominant cluster was related to the New York/Japanese clone. A new spa t14789, and ST1510 never reported in Brazil were identified.

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Epidemiological Typing of Methicillin Resistant Staphylococcus aureus Isolated from Surgical Site Infection Following Caesarean Section in an Egyptian University Hospital

El-Nasser

Salakawy

Mira

et al. 2019

The Egyptian Journal of Hospital Medicine

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MRSA outbreak at a transplantation unit

Cited by 4 publications

References 19 publications

<div>Methicillin-resistant <em>Staphylococcus aureus</em> bacteremia among liver transplant recipients: epidemiology and associated risk factors for morbidity and mortality</div>

<div>Methicillin-resistant <em>Staphylococcus aureus</em> bacteremia among liver transplant recipients: epidemiology and associated risk factors for morbidity and mortality</div>

Staphylococcus aureus isolates colonizing and infecting cirrhotic and liver-transplantation patients: comparison of molecular typing and virulence factors

Epidemiological Typing of Methicillin Resistant Staphylococcus aureus Isolated from Surgical Site Infection Following Caesarean Section in an Egyptian University Hospital

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