MRS Findings in Cerebral Coenurosis due to <i>Taenia Multiceps</i>

Ambekar, Sudheer; Prasad, Chandrajit; Srinivas, Dwarakanath; Mahadevan, A

doi:10.1111/j.1552-6569.2011.00616.x

Cited by 15 publications

(6 citation statements)

References 10 publications

(18 reference statements)

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“…T. multiceps infection in sheep results in significant economic losses in many parts of the world, predominantly in the developing countries of Africa, Europe, and Southeast Asia (1,6,7). Cases of human infections due to accidental ingestion of T. multiceps eggs have also been reported frequently and cause serious pathological conditions (8)(9)(10)(11)(12). Cestode development is well-known to involve complex morphological and physiological changes associated with changes in the host species (13,14).…”

Section: Introductionmentioning

confidence: 99%

Comparative Transcriptome Analyses of the Developmental Stages of Taenia multiceps

Yang

Zhang

et al. 2021

Front. Vet. Sci.

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Cerebral coenurosis, caused by the larvae of Taenia multiceps (Coenurus cerebralis), is a fatal central nervous system disease in sheep and other herbivores and occasionally humans. Comparative transcriptomic profiles of the developmental stages of the parasite remain unknown. In this study, RNA sequencing was used to determine the transcriptome profiles of different stages of the life cycle of T. multiceps, including Oncosphere, Coenurus cerebralis (Pro with Cyst), and Adult (Adu), as well as scolex-neck proglottids (Snp), immature–mature proglottids (Imp), and gravid proglottids (Grp) of the adult stage. A total of 42.6 Gb (average 6.1 Gb) Illumina pair-end reads with a 125-bp read length were generated for seven samples. The total number of differentially expressed genes (DEGs) in the various life stages ranged from 2,577 to 3,879; however, for the tissues of the adult worm, the range was from 1,229 to 1,939. Kyoto Encyclopedia of Genes and Genomes analysis showed that the DEGs mainly participated in cellular and metabolic processes, binding and catalytic activity, genetic information processing, and environmental information processing. In addition, a large number of genes related to development and parasite–host interaction were identified. Quantitative reverse transcription-polymerase chain reaction confirmed that the levels of 28 selected DEGs were consistent with those determined using RNA sequencing. The present study provides insights into the mechanisms of the development and parasitic life of T. multiceps.

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Section: Introductionmentioning

confidence: 99%

Comparative Transcriptome Analyses of the Developmental Stages of Taenia multiceps

Yang

Zhang

et al. 2021

Front. Vet. Sci.

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“…Several human cases of cerebral coenurosis have been reported (AMBEKAR et al, 2013;ANTONIOS & MINA, 2000;COLLOMB et al, 2007;HAITCHI et al, 2012;SCHELLHAS & NORRIS, 1985) due to consumption of contaminated foods with T. multiceps eggs and develop the same pathogenesis as described in other intermediate hosts (ACHA & SZYFRES, 2003).…”

Section: First Report Of An Outbreak Of Cerebral Coenurosis In Dhofarmentioning

confidence: 91%

First report of an outbreak of cerebral coenurosis in Dhofari goats in Oman

El-Neweshy

Khalafalla

Ahmed

et al. 2019

Rev. Bras. Parasitol. Vet.

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This study documented the first outbreak of cerebral coenurosis in goats in Salalah, southern Oman. Deaths of 130 (16.6%) adult native goats in a herd (n=780) were reported from January to June 2017. Affected goats showed various nervous signs ended by death. Investigations for thiamine deficiency, polioencephalomalacia, caprine arthritis encephalitis, and listeriosis were negative. Upon necropsy, multiple (1-4) thin-walled cysts 2-3.5 cm in diameter containing clear fluid with numerous clusters of protoscolices in the cerebrum and cerebellum had replaced the brain parenchyma, causing space-occupying lesions. Parasitologically, the recovered cysts were Coenurus cerebralis, based on the arrangement of protoscolices, and the number and size of their hooks. Morphologically, each protoscolex had four suckers and a rostellum with double-crown hooks. The large and small hooks were 157.7±0.5 µm and 115±0.6 µm in length, respectively. Histopathologically, the parasite destroyed the affected tissues associated with multifocal to diffuse lymphocytic, non-suppurative meningoencephalitis; ischemic neuronal necrosis; and malacia. This is the first report of cerebral coenurosis in livestock in Oman, which should alert the local public health authorities for the application of prevention and control measures.

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“…No definitive drug regimens recommendations exist, although antihelminthic treatment with albendazole and praziquantel has been reported with success. 4,29 We acknowledge limitations in this study in terms of its retrospective nature, small dataset, and nonavailability of a few imaging sequences (including thin section heavily T2-weighted imaging or steady-state MR imaging) in some patients.…”

Section: Pathologymentioning

confidence: 99%

Brain MRI Findings in Coenurosis: A Helminth Infection

Kulanthaivelu

Bhat

Prasad

et al. 2020

Journal of Neuroimaging

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Parasitic neuroinfections in humans have etiological agents spanning a broad spectrum from unicellular (protozoan) to multicellular helminthic (metazoan) organisms. Cerebral coenurosis is a rare cestodal helminthic infection caused by Taenia multiceps. The neuroimaging features of this entity were reviewed to discern an imaging phenotype. METHODS:Retrospective analysis was performed on 6 cases of cerebral coenurosis, whose diagnoses were confirmed by histopathology. The clinical, imaging, and histopathological features were recorded for analysis. RESULTS: Clinical expressions included focal neurological deficit due to mass effect (n = 4), intraventricular obstruction with features of raised intracranial tension (n = 1), headache (n = 3), seizures (n = 3), and incidental lesions (n = 1). One patient presented with recurrence 1 year after surgical excision. Neuroimaging revealed cystic thin-walled lesions with clustered eccentric internal nodules corresponding to the plenitude of protoscolices of the tapeworm. Three of the lesions showed a multilocular cystic morphology. Spectroscopic metabolite signature of alanine and succinate commensurate with the parasitic etiology was remarkable in the lesions. Enhancement and edema inversely correlated with the signal suppression on fluid-attenuated inversion recovery (FLAIR) imaging. The lesions had a predominantly juxtacortical distribution. CONCLUSIONS: In an appropriate clinical setting, a cystic lesion with clustered eccentric internal nodular foci ought to raise the suspicion of this rare infection. Magnetic resonance spectroscopic signature of succinate and alanine, if present, further strengthens the likelihood of coenurosis. Signal characteristics, wall enhancement, and perilesional edema may vary, possibly determined by the stage in the evolution of the parasite.

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MRS Findings in Cerebral Coenurosis due to Taenia Multiceps

Cited by 15 publications

References 10 publications

Comparative Transcriptome Analyses of the Developmental Stages of Taenia multiceps

Comparative Transcriptome Analyses of the Developmental Stages of Taenia multiceps

First report of an outbreak of cerebral coenurosis in Dhofari goats in Oman

Brain MRI Findings in Coenurosis: A Helminth Infection

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